Evidence
Neurol Neuroimmunol Neuroinflamm. 2023 Jun 20;10(5):e200121. doi: 10.1212/NXI.0000000000200121. Print 2023 Sep.
ABSTRACT
Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta.
PMID:37339889 | DOI:10.1212/NXI.0000000000200121
Add to Google Keep
Estimated reading time: 2 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
🌐 90 Days
VR Related Evidence Matrix
- Progressive Encephalomyelopathy in an Older Man: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings
- Life-Threatening MOG Antibody-Associated Hemorrhagic ADEM With Elevated CSF IL-6
- MOG Antibody-Associated Disease in the Setting of Metastatic Melanoma Complicated by Immune Checkpoint Inhibitor Use
- Management of Autoimmune Encephalitis in a 7-Year-Old Child With CTLA-4 Haploinsufficiency and AMPA Receptor Antibodies: A Case Report
- Single-Cell Multi-Omics Map of Cell Type-Specific Mechanistic Drivers of Multiple Sclerosis Lesions
- Comparative Study of Paraneoplastic and Nonparaneoplastic Autoimmune Encephalitis With GABABR Antibodies
- Six Year Old With Chronic Headache: An Unexpected Meningitis Mimic
- Six Year Old With Chronic Headache: An Unexpected Meningitis Mimic
- Predictors and Clinical Characteristics of Relapses in LGI1-Antibody Encephalitis
- Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial
- Synaptic Protein Loss in Extracellular Vesicles Reflects Brain and Retinal Atrophy in People With Multiple Sclerosis
- Recurrent depressive disorder associated with an atypical CADASIL syndrome
- Phenotypic Insights Into Anti-IgLON5 Disease in IgLON5-Deficient Mice
- Haemosuccus pancreaticus and seven episodes of recurrent unlocalised upper gastrointestinal bleeding
- Recurrent Acute-on-Chronic Pancreatitis in a Chronic Alcoholic With Pancreatic Divisum: A Complex Case
- Reader Response: Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline: Report of the AAN Guidelines Subcommittee, AAP, CNS, and SCCM
- Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial
- Teaching Video NeuroImage: Who Says Only Cardiologists Need Good Ears: Listening to Neurologic Footfall
- Recurrent involuntary memories and mind wandering are related but distinct
- Case report: Association between PTEN-gene variant and an aggressive case of multiple dAVFs
- Absence of a Superior Colliculus Causing Gaze Deviation in a 6-Month-Old Boy: Case Report
- Intensive exposure treatment for obsessive compulsive disorder in old age.
- Gene-Gene Interaction Between Factor-XI and ABO Genes in Cerebral Venous Thrombosis: The BEAST Study
- SARS-CoV-2 Infection and Risk of Postacute Psychiatric and Neurologic Diagnoses: A Nationwide Danish Cohort Study
- Recurrent ATP1A1 variant Gly903Arg causes developmental delay, intellectual disability, and autism
- Pearls & Oy-sters: AARS2 Leukodystrophy-Tremor and Tribulations
- The complement system in neurodegenerative diseases
- Immunological and hematological findings as major features in a patient with a new germline pathogenic CBL variant
- Factors associated with meningitis vaccine awareness and engagement among Latino men who have sex with men in South Florida
- Allele-Specific Regulation of the Candidate Autism Liability Gene RAI1 by the Enhancer Variant rs4925102 (C/G)
- The Phenotypic Spectrum of Desanto-Shinawi Syndrome: A Comparative Report of the First Reported Case in Turkey
- Case report: A novel mutation of glial fibrillary acidic protein gene causing juvenile-onset Alexander disease
- Case report: A novel mutation of glial fibrillary acidic protein gene causing juvenile-onset Alexander disease
- Endoscopic Dilatation with Ultrathin Endoscope Assisted Method for Esophageal and Pyloric Stricture related Corrosive Injury: 4 Years Case Series Study
- Unexplained recurrent high fever observed in a depressed adolescent
- 3q29 duplications: A cohort of 46 patients and a literature review
- Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy
- Hypokalaemia associated with excessive cola-flavoured drinks consumption
- Inhibitory roles of Apolipoprotein E Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models
- The Cultural Formulation Interview as a clinical tool in the assessment of eating disorders: a pilot study
- Phenotypic Description of A Patient with ODLURO Syndrome and Functional Characterization of the Pathogenetic Role of A Synonymous Variant c.186G>A in KMT2E Gene
- Patient with Asperger's Syndrome, with episodes of fantasizing and rocking of body, treated with aripiprazole - a case report
- The Cultural Formulation Interview as a clinical tool in the assessment of eating disorders: a pilot study
- Defining "High Recurrence" of Depressive Episodes for Predicting Diagnostic Conversion from Major Depressive Disorder to Bipolar Disorder: A 5-year Retrospective Study
- Delusions of love and passion in the behavioral variant of frontotemporal dementia
- Syrian child carrying multiple pathogenic variants in MBOAT7 and MT-TS1 genes: a case report on neurodevelopmental phenotypes and mitochondrial inheritance
- Syrian child carrying multiple pathogenic variants in MBOAT7 and MT-TS1 genes: a case report on neurodevelopmental phenotypes and mitochondrial inheritance
- Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
- Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
- Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
- Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
- Clinical characteristics and outcomes of acute bacterial meningitis in adults at a tertiary university hospital in Thailand
- Unexplained recurrent high fever observed in a depressed adolescent
- Lifestyle Factors Associated With Frequent Recurrent Headaches in Children and Adolescents: A Canadian Population-Based Study
- CyberKnife stereotactic radiosurgery for extramedullary plasmacytoma in the external auditory canal: illustrative case
- Pathogenicity of de novo CACNA1D Ca2+ channel variants predicted from sequence co-variation
- Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
- ICA Bonsai
- Right Brain: Death Protocols
- Stroke Thrombolysis: Can You Feel the Need for Speed?
- Risk of Recurrent Stroke and Mortality Among Black and White Patients With Poststroke Depression
- Symptomatic progression of frontotemporal dementia with the TARDBP I383V variant
- What Is the Role of Lactate in Brain Metabolism, Plasticity, and Neurodegeneration?
- Undiagnosed rare disease clinic identifies a novel UBE3A variant in two sisters with Angelman syndrome: The end of a diagnostic odyssey
Evidence Blueprint
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
🌐 365 Days
VR Related Evidence Matrix
- Tuberculous Meningitis or Neurosarcoidosis-a Diagnostic Quandary
- Progressive Encephalomyelopathy in an Older Man: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings
- A 42-Year-Old Woman With Rapidly Expanding White Matter Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
- Life-Threatening MOG Antibody-Associated Hemorrhagic ADEM With Elevated CSF IL-6
- A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
- MOG Antibody-Associated Disease in the Setting of Metastatic Melanoma Complicated by Immune Checkpoint Inhibitor Use
- Immune Checkpoint Inhibition-Related Myasthenia-Myositis-Myocarditis Responsive to Complement Blockade
- Management of Autoimmune Encephalitis in a 7-Year-Old Child With CTLA-4 Haploinsufficiency and AMPA Receptor Antibodies: A Case Report
- HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS
- Single-Cell Multi-Omics Map of Cell Type-Specific Mechanistic Drivers of Multiple Sclerosis Lesions
- Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
- Comparative Study of Paraneoplastic and Nonparaneoplastic Autoimmune Encephalitis With GABABR Antibodies
- Six Year Old With Chronic Headache: An Unexpected Meningitis Mimic
- Six Year Old With Chronic Headache: An Unexpected Meningitis Mimic
- CXCL10/IgG1 Axis in Multiple Sclerosis as a Potential Predictive Biomarker of Disease Activity
- Antibodies Associated With Autoimmune Encephalitis in Patients With Presumed Neurodegenerative Dementia
- CD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica
- Impact of Immune Checkpoint Inhibitors on the Course of Multiple Sclerosis
- Predictors and Clinical Characteristics of Relapses in LGI1-Antibody Encephalitis
- Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial
- Mimics of Autoimmune Encephalitis: Validation of the 2016 Clinical Autoimmune Encephalitis Criteria
- Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits in the Long-term Course of Limbic Encephalitis
- Synaptic Protein Loss in Extracellular Vesicles Reflects Brain and Retinal Atrophy in People With Multiple Sclerosis
- Recurrent depressive disorder associated with an atypical CADASIL syndrome
- A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells
- Phenotypic Insights Into Anti-IgLON5 Disease in IgLON5-Deficient Mice
- Childhood-Onset Myopathy With Preserved Ambulation Caused by a Recurrent ADSSL1 Missense Variant
- Child Neurology: Mucopolysaccharidosis IIID: Evidence From Ultrastructural and Genomic Study
- Haemosuccus pancreaticus and seven episodes of recurrent unlocalised upper gastrointestinal bleeding
- Pearls & Oy-sters: CACNA1A-Related Paroxysmal Tonic Upgaze With Ataxia Responsive to Acetazolamide
- TNRSF1A-pR92Q variant identifies a subset of patients more similar to systemic undifferentiated recurrent fever than TNF receptor-associated periodic syndrome
- Recurrent Acute-on-Chronic Pancreatitis in a Chronic Alcoholic With Pancreatic Divisum: A Complex Case
- Reader Response: Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline: Report of the AAN Guidelines Subcommittee, AAP, CNS, and SCCM
- Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial
- Heterozygous Nonsense Variants in the Ferritin Heavy Chain Gene FTH1 Cause a Neuroferritinopathy
- Expression and distribution of hypoxia-inducible factor-1α and vascular endothelial growth factor in comparison between radiation necrosis and tumor tissue in metastatic brain tumor: A case report
- Integration of EpiSign, facial phenotyping, and likelihood ratio interpretation of clinical abnormalities in the re-classification of an ARID1B missense variant
- Mother and Daughter with Short Stature, Microcephaly, Mild Dysmorphic Features, and Learning Disabilities Due to Ververi-Brady Syndrome Associated with a New Variant of the QRICH1 Gene
- Non-alcoholic fatty liver disease in a pediatric patient with heterozygous familial hypobetalipoproteinemia due to a novel APOB variant: a case report and systematic literature review
- Biallelic Variants in Seven Different Genes Associated with Clinically Suspected Bardet-Biedl Syndrome
- Status epilepticus in a pregnant patient with a previously unrecognized POLG-associated disease
- Haematohidrosis: A Case Series of Five Patients
- How Far Are We in Translating the Multiple Sclerosis Prodromes in Clinical Practice?
- Teaching Video NeuroImage: Who Says Only Cardiologists Need Good Ears: Listening to Neurologic Footfall
- Recurrent involuntary memories and mind wandering are related but distinct
- From Clinical Trials to Memory Clinics, tau-PET Visual Reads Can Help Diagnosis and Patient Stratification
- Association Between Peer Victimization, Gender Diversity, Mental Health, and Recurrent Headaches in Adolescents: A Canadian Population-Based Study
- Case report: Association between PTEN-gene variant and an aggressive case of multiple dAVFs
- Child Neurology: Progressive Cerebellar Atrophy and Retinal Dystrophy - Clues to an Ultra-Rare ACO2-Related Neurometabolic Diagnosis
- Honokiol in glioblastoma recurrence: a case report
- Absence of a Superior Colliculus Causing Gaze Deviation in a 6-Month-Old Boy: Case Report
- Intensive exposure treatment for obsessive compulsive disorder in old age.
- Child Neurology: Anti-Hu Encephalitis in an Adolescent With a Mediastinal Seminoma
- PUF60-related developmental disorder: A case series and phenotypic analysis of 10 additional patients with monoallelic PUF60 variants
- Long-term outcomes in two adult siblings with Fucosidosis - Diagnostic odyssey and clinical manifestations
- Genetic characterization of Schuurs-Hoeijmakers syndrome in a moroccan individual with heterozygote PACS1 mutation
- Awake resection of recurrent astroblastoma with intraoperative 5-ALA-induced fluorescence: illustrative case
- Recurrent malignant ventricular arrhythmias and paresthesia-a mystery revealed as aconitine poisoning: a case report
- Tatton-Brown-Rahman Syndrome: Case report and DNMT3A variant not previously reported associated to the syndrome
- Gene-Gene Interaction Between Factor-XI and ABO Genes in Cerebral Venous Thrombosis: The BEAST Study
- Identification of potential molecular mechanisms and therapeutic targets for recurrent pelvic organ prolapse
- Transient splenial lesion syndrome in bipolar-II disorder: a case report highlighting reversible brain changes during hypomanic episodes
- A novel biallelic frameshift variant in C2orf69 causing developmental regression, seizures, microcephaly, autistic features, and hypertonia
- Alzheimer's disease-associated complement gene variants influence plasma complement protein levels