Evidence
Neurol Neuroimmunol Neuroinflamm. 2023 Jun 20;10(5):e200121. doi: 10.1212/NXI.0000000000200121. Print 2023 Sep.
ABSTRACT
Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta.
PMID:37339889 | DOI:10.1212/NXI.0000000000200121
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Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
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Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
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