J Xray Sci Technol. 2024 May 29. doi: 10.3233/XST-230426. Online ahead of print.

ABSTRACT

BACKGROUND: Connectome is understanding the complex organization of the human brain’s structural and functional connectivity is essential for gaining insights into cognitive processes and disorders.

OBJECTIVE: To improve the prediction accuracy of brain disorder issues, the current study investigates dysconnected subnetworks and graph structures associated with schizophrenia.

METHOD: By using the proposed structural connectivity-deep graph neural network (sc-DGNN) model and compared with machine learning (ML) and deep learning (DL) models.This work attempts to focus on eighty-eight subjects of diffusion magnetic resonance imaging (dMRI), three classical ML, and five DL models.

RESULT: The structural connectivity-deep graph neural network (sc-DGNN) model is proposed to effectively predict dysconnectedness associated with schizophrenia and exhibits superior performance compared to traditional ML and DL (GNNs) methods in terms of accuracy, sensitivity, specificity, precision, F1-score, and Area under receiver operating characteristic (AUC).

CONCLUSION: The classification task on schizophrenia using structural connectivity matrices and experimental results showed that linear discriminant analysis (LDA) performed 72% accuracy rate in ML models and sc-DGNN performed at a 93% accuracy rate in DL models to distinguish between schizophrenia and healthy patients.

PMID:38820060 | DOI:10.3233/XST-230426