Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Sci Rep. 2024 May 22;14(1):11716. doi: 10.1038/s41598-024-62593-z.
ABSTRACT
Postoperative delirium (POD) is a common complication in older patients with hepatocellular carcinoma (HCC) that adversely impacts clinical outcomes. We aimed to evaluate the risk factors for POD and to construct a predictive nomogram. Data for a total of 1481 older patients (training set: n=1109; validation set: n=372) who received liver resection for HCC were retrospectively retrieved from two prospective databases. The receiver operating characteristic (ROC) curve, calibration plot, and decision curve analysis (DCA) were used to evaluate the performance. The rate of POD was 13.3% (148/1109) in the training set and 16.4% (61/372) in the validation set. Multivariate analysis of the training set revealed that factors including age, history of cerebrovascular disease, American Society of Anesthesiologists (ASA) classification, albumin level, and surgical approach had significant effects on POD. The area under the ROC curves (AUC) for the nomogram, incorporating the aforementioned predictors, was 0.798 (95% CI 0.752-0.843) and 0.808 (95% CI 0.754-0.861) for the training and validation sets, respectively. The calibration curves of both sets showed a degree of agreement between the nomogram and the actual probability. DCA demonstrated that the newly established nomogram was highly effective for clinical decision-making. We developed and validated a nomogram with high sensitivity to assist clinicians in estimating the individual risk of POD in older patients with HCC.
PMID:38777824 | DOI:10.1038/s41598-024-62593-z
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study The relationship between intraoperative hypothermia and postoperative delirium: The PNDRFAP study Association of preoperative neutrophil-to-lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) Serum NPTX2 as a Potential Predictive Biomarker for Postoperative Delirium in Patients with Acute Type A Aortic Dissection Development and internal validation of a nomogram to predict temporary acute agitated delirium after surgery for chronic subdural hematoma in elderly patients: an analysis of the clinical database Development and internal validation of a nomogram to predict temporary acute agitated delirium after surgery for chronic subdural hematoma in elderly patients: an analysis of the clinical database Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study Preoperative prediction of HER-2 expression status in breast cancer based on MRI radiomics model Preoperative prediction of HER-2 expression status in breast cancer based on MRI radiomics model Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study Development and validation of a nomogram for predicting depressive symptoms in dentistry patients: A cross-sectional study Associations between postoperative cognitive dysfunction, serum interleukin-6 and postoperative delirium among patients after coronary artery bypass grafting: A mediation analysis A nomogram for predicting postoperative delirium in pediatric patients following cardiopulmonary bypass: A prospective observational study Interpretable machine learning model for early prediction of delirium in elderly patients following intensive care unit admission: a derivation and validation study Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma Development and validation of a nomogram for predicting high-burnout risk in nurses MRI radiomics based on deep learning automated segmentation to predict early recurrence of hepatocellular carcinoma A Novel Preoperative Electroencephalogram-Derived Index to Predict Early Postoperative Delirium in Elderly Patients After Hip Fracture Surgeries: Development of a Prediction Model Association between pediatric postoperative delirium and regional cerebral oxygen saturation: a prospective observational study Development and validation of a risk prediction model for aspiration in patients with acute ischemic stroke Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study Association Between Preoperative Sleep Disturbance and Postoperative Delirium in Elderly: A Retrospective Cohort Study Patients undergoing liver resection for non-alcoholic fatty liver disease-related hepatocellular carcinoma and those for viral hepatitis-related hepatocellular carcinoma have similar survival outcomes Updated ESAIC guidelines on postoperative delirium in adults Predicting Survival Using Whole-Liver MRI Radiomics in Patients with Hepatocellular Carcinoma After TACE Refractoriness Intraoperative electroencephalogram patterns as predictors of postoperative delirium in older patients: a systematic review and meta-analysis A predictive model for depression in Chinese middle-aged and elderly people with physical disabilities Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique Unraveling the Predictors for Delirium and ICU Stay Duration in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF) Undergoing Coronary Artery Bypass Grafting-A Multicentric Analysis Effects of Chinese traditional five-element music intervention on postoperative delirium and sleep quality in elderly patients after non-cardiac surgery: a randomized controlled trial SGLT2i impact on HCC incidence in patients with fatty liver disease and diabetes: a nation-wide cohort study in South Korea COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications Machine learning-based model to predict delirium in patients with advanced cancer treated with palliative care: a multicenter, patient-based registry cohort Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis Value of constructing a non-invasive diagnostic model based on serum heme oxygenase-1 and glucose regulatory protein 78 for non-alcoholic fatty liver disease Improving the Prognostic Evaluation Precision of Hospital Outcomes for Heart Failure Using Admission Notes and Clinical Tabular Data: Multimodal Deep Learning Model Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors Dynamic Delirium Prediction in the Intensive Care Unit using Machine Learning on Electronic Health Records Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study Three-Dimensional Structure of Novel Liver Cancer Biomarker Liver Cancer-Specific Serine Protease Inhibitor Kazal (LC-SPIK) and Its Performance in Clinical Diagnosis of Hepatocellular Carcinoma (HCC) Analysis of risk factors of suicidal ideation in adolescent patients with depression and construction of prediction model Analysis of risk factors of suicidal ideation in adolescent patients with depression and construction of prediction model Clinical outcomes of hepatocellular carcinoma surveillance in Melbourne, Australia The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH Evaluating accuracy and fairness of clinical decision support algorithms when health care resources are limited The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease Development and validation of a machine learning model to predict postoperative delirium using a nationwide database: A retrospective, observational study Effects of Intranasal Insulin Pretreatment on Preoperative Sleep Quality and Postoperative Delirium in Patients Undergoing Valve Replacement for Rheumatic Heart Disease Impact of intraoperative dexmedetomidine on postoperative delirium and pro-inflammatory cytokine levels in elderly patients undergoing thoracolumbar compression fracture surgery: A prospective, randomized, placebo-controlled clinical trial Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study Prediction of Amyloid Positivity in Patients with Subcortical Vascular Cognitive Impairment The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery Identification of patients with internet gaming disorder via a radiomics-based machine learning model of subcortical structures in high-resolution T1-weighted MRI
Evidence Blueprint
Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study The relationship between intraoperative hypothermia and postoperative delirium: The PNDRFAP study Association of preoperative neutrophil-to-lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) Serum NPTX2 as a Potential Predictive Biomarker for Postoperative Delirium in Patients with Acute Type A Aortic Dissection Development and internal validation of a nomogram to predict temporary acute agitated delirium after surgery for chronic subdural hematoma in elderly patients: an analysis of the clinical database Development and internal validation of a nomogram to predict temporary acute agitated delirium after surgery for chronic subdural hematoma in elderly patients: an analysis of the clinical database Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study Preoperative prediction of HER-2 expression status in breast cancer based on MRI radiomics model Preoperative prediction of HER-2 expression status in breast cancer based on MRI radiomics model Association Between Preoperative Long-Term Poor Sleep Quality and Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery: A Multi-Center Observational Study Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study Risk prediction models for postoperative delirium in elderly patients with fragility hip fracture: A systematic review and critical appraisal Development and validation of a nomogram for predicting depressive symptoms in dentistry patients: A cross-sectional study Associations between postoperative cognitive dysfunction, serum interleukin-6 and postoperative delirium among patients after coronary artery bypass grafting: A mediation analysis A nomogram for predicting postoperative delirium in pediatric patients following cardiopulmonary bypass: A prospective observational study Interpretable machine learning model for early prediction of delirium in elderly patients following intensive care unit admission: a derivation and validation study Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma Development and validation of a nomogram for predicting high-burnout risk in nurses Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study MRI radiomics based on deep learning automated segmentation to predict early recurrence of hepatocellular carcinoma A Novel Preoperative Electroencephalogram-Derived Index to Predict Early Postoperative Delirium in Elderly Patients After Hip Fracture Surgeries: Development of a Prediction Model Association between pediatric postoperative delirium and regional cerebral oxygen saturation: a prospective observational study Risk Stratification Model for Hepatocellular Cancer in Patients With Cirrhosis Development and validation of a risk prediction model for aspiration in patients with acute ischemic stroke The Association of Preoperative Diabetes With Postoperative Delirium in Older Patients Undergoing Major Orthopedic Surgery: A Prospective Matched Cohort Study A risk prediction model for hepatocellular carcinoma in non-alcoholic fatty liver disease without cirrhosis: HCC prediction for non-cirrhotic NAFLD Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study Cigarette smoking is linked to an increased risk of delirium following arthroplasty in patients suffering from osteoarthritic pain Association Between Preoperative Sleep Disturbance and Postoperative Delirium in Elderly: A Retrospective Cohort Study Patients undergoing liver resection for non-alcoholic fatty liver disease-related hepatocellular carcinoma and those for viral hepatitis-related hepatocellular carcinoma have similar survival outcomes Updated ESAIC guidelines on postoperative delirium in adults Predicting Survival Using Whole-Liver MRI Radiomics in Patients with Hepatocellular Carcinoma After TACE Refractoriness Intraoperative electroencephalogram patterns as predictors of postoperative delirium in older patients: a systematic review and meta-analysis A predictive model for depression in Chinese middle-aged and elderly people with physical disabilities Perioperative point-of-care-testing of plasmacholinesterases identifies older patients at risk for postoperative delirium: an observational prospective cohort study Diabetic foot ulcers risk prediction in patients with type 2 diabetes using classifier based on associations rule mining Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique Unraveling the Predictors for Delirium and ICU Stay Duration in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF) Undergoing Coronary Artery Bypass Grafting-A Multicentric Analysis Effects of Chinese traditional five-element music intervention on postoperative delirium and sleep quality in elderly patients after non-cardiac surgery: a randomized controlled trial SGLT2i impact on HCC incidence in patients with fatty liver disease and diabetes: a nation-wide cohort study in South Korea COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies Refinement and validation of a comprehensive clinical diagnostic model (GAMAD) based on gender, age, multitarget circulating tumour DNA methylation signature and commonly used serological biomarkers for early detection of hepatocellular… Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications Machine learning-based model to predict delirium in patients with advanced cancer treated with palliative care: a multicenter, patient-based registry cohort Comparison between models for detecting hepatocellular carcinoma in patients with chronic liver diseases of various etiologies: ASAP score versus GALAD score A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis Value of constructing a non-invasive diagnostic model based on serum heme oxygenase-1 and glucose regulatory protein 78 for non-alcoholic fatty liver disease Improving the Prognostic Evaluation Precision of Hospital Outcomes for Heart Failure Using Admission Notes and Clinical Tabular Data: Multimodal Deep Learning Model Hepatocellular carcinoma surveillance - utilization, barriers and the impact of changing aetiology Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors Identification and validation of cuproptosis-related molecular clusters in non-alcoholic fatty liver disease