From gut microbiota to brain: implications on binge eating disorders
Evidence
Gut Microbes. 2024 Jan-Dec;16(1):2357177. doi: 10.1080/19490976.2024.2357177. Epub 2024 May 23.
ABSTRACT
The prevalence of eating disorders has been increasing over the last 50 years. Binge eating disorder (BED) and bulimia nervosa (BN) are two typical disabling, costly and life-threatening eating disorders that substantially compromise the physical well-being of individuals while undermining their psychological functioning. The distressing and recurrent episodes of binge eating are commonly observed in both BED and BN; however, they diverge as BN often involves the adoption of inappropriate compensatory behaviors aimed at averting weight gain. Normal eating behavior is coordinated by a well-regulated trade-off between intestinal and central ingestive mechanism. Conversely, despite the fact that the etiology of BED and BN remains incompletely resolved, emerging evidence corroborates the notion that dysbiosis of gastrointestinal microbiome and its metabolites, alteration of gut-brain axis, as well as malfunctioning central circuitry regulating motivation, execution and reward all contribute to the pathology of binge eating. In this review, we aim to outline the current state of knowledge pertaining to the potential mechanisms through which each component of the gut-brain axis participates in binge eating behaviors, and provide insight for the development of microbiome-based therapeutic interventions that hold promise in ameliorating patients afflicted with binge eating disorders.
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Adv Neurobiol. 2024;35:315-327. doi: 10.1007/978-3-031-45493-6_16.ABSTRACTThis chapter (part one of a trilogy) summarizes the neurobiological foundations of endogenous opioids in the regulation of energy balance and...
PCN Rep. 2023 Nov 6;2(4):e151. doi: 10.1002/pcn5.151. eCollection 2023 Dec.ABSTRACTAIM: Patients with anorexia nervosa (AN) sometimes undergo a chronic course, and they hardly maintain social...
J Nutr Metab. 2024 Jun 5;2024:5953893. doi: 10.1155/2024/5953893. eCollection 2024.ABSTRACTOBJECTIVE: To assess selected cardiometabolic risk factors among Saudi women with eating disorders.METHODS: An epidemiological, cross-sectional...
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