Evidence
Brain Behav. 2023 Aug 7:e3204. doi: 10.1002/brb3.3204. Online ahead of print.
ABSTRACT
INTRODUCTION: This study aimed to investigate the treatment effect of G protein-coupled receptor 30 (GPR30) agonist G1 combined with hypothermia (HT) on cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage (SAH) in rats.
METHODS: Fifty male rats were randomly assigned to one of five groups: Sham group, SAH group, SAH + G1 group, SAH + HT group, and SAH + G1 + HT group. The SAH rat model was established by modified endovascular puncture in all groups except the Sham group. Neurological function after the operation was assessed by Garcia scoring. The degree of rat cerebral edema was determined using dry-wet weighing method on the 28th day after operation. Moreover, the behavioral test was performed on rats on the 4th and 28th days after operation.
RESULTS: Compared with Sham group, the Garcia score of each SAH rat model group decreased significantly on the first day and thereafter increased gradually. However, the recovery rate of each treatment group was higher than the SAH group (no treatment), and the Garcia score of SAH + G1 + HT group was much higher than the SAH group on the seventh day after operation. In addition, each treatment group could obviously reduce the cerebral edema degree of SAH rats, among which rats in SAH + G1 + HT group had lower cerebral edema degree than SAH + G1 group and SAH + HT group. Behavioral test results showed that the combination of GPR30 agonist G1 and HT markedly improved the learning and memory ability of SAH rats, alleviated their anxiety- and emotion-related behavior, and enhanced their social interaction.
CONCLUSION: GPR30 agonist G1 combined with HT reduces cognitive impairment and anxiety-like behavior in rats with SAH.
PMID:37548479 | DOI:10.1002/brb3.3204
Add to Google Keep
Estimated reading time: 5 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
GPR30 agonist G1 combined with hypothermia alleviates cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage in rats
🌐 90 Days
VR Related Evidence Matrix
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
- S100A9 aggravates early brain injury after subarachnoid hemorrhage via inducing neuroinflammation and inflammasome activation
- Subarachnoid Hemorrhage Confirmed by Magnetic Resonance Imaging in a Patient with Brain Death owing to Hypoxic Encephalopathy Following Suicide by Hanging
- The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury
- Effects of carbamazepine on BDNF expression in trigeminal ganglia and serum in rats with trigeminal neuralgia
- Hypo-attenuating Berry Sign as a Novel Imaging Marker of Ruptured Aneurysm in Patients with Subarachnoid Hemorrhage; a Diagnostic Accuracy Study
- MiR-21-5p alleviates trigeminal neuralgia in rats through down-regulation of voltage-gated potassium channel Kv1.1
- Randomized-controlled trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis
- Function and mechanism exploring of icariin in schizophrenia through network pharmacology
- Repair effect of different doses of human umbilical cord mesenchymal stem cells on white matter injury in neonatal rats
- Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A(1) Receptor Agonist and Body Cooling
- Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A(1) Receptor Agonist and Body Cooling
- Effects of chronic social equality and inequality conditions on passive avoidance memory and PTSD-like behaviors in rats under chronic empathic stress
- Clinical Efficacy of Sun's Abdominal Acupuncture Combined with CBTI in Treating Chronic Insomnia with Anxiety
- The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field
- Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model
- Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
- Neuroprotective effects of quinpirole on lithium chloride pilocarpine-induced epilepsy in rats and its underlying mechanisms
- Rosiglitazone Promotes Microglial Distribution via Activation of PPARγ and CD36 in the ICH Rat Model
- Effect of biofeedback intervention on neurological characteristics of children with attention deficit hyperactivity disorder
- Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
- The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor
- Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats
- Mechanism of astragaloside Ⅳ combined with Panax notoginseng saponins in regulating angiogenesis to treat cerebral ischemia based on network pharmacology and experimental verification
- Taurine Regulates the Expression of Interleukin -17/10 and Intestinal Flora and Protects the Liver and Intestinal Mucosa in a Nonalcoholic Fatty Liver Disease Rat Model
- Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies
- The Effect of Propofol on the Hippocampus in Chronic Cerebral Hypoxia in a Rat Model Through Klotho Regulation
- Traditional pediatric massage enhanced hippocampal GR, BDNF and IGF-1 expressions and exerted an anti-depressant effect in an adolescent rat model of CUMS-induced depression
- Transcranial Direct Current Stimulation for Anxiety During Laparoscopic Colorectal Cancer Surgery: A Randomized Clinical Trial
- Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora
- Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy: A Multicenter Pilot Randomized Clinical Trial
- Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats
- Is Reiki effective in reducing heart rhythm, cortisol and anxiety and improving biochemical parameters in individuals with cardiac disesase? Randomized placebo-controlled trial
- Mitochondrial transplantation combined with coenzyme Q10 induces cardioprotection and mitochondrial improvement in aged male rats with reperfusion injury
- The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
- Acupressure bladder meridian alleviates anxiety disorder in rats by regulating MAPK and BDNF signal pathway
- The relationship between cardiorespiratory fitness and inhibitory control following acute stress: An ERP study
- The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats
- Tanshinone _A inhibits ferroptosis via Nrf2 signaling pathway to protect liver in rats of non-alcoholic fatty liver disease
- Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity
- Effects of transcranial direct current stimulation combined with tinnitus retraining therapy on sleep disorders in patients with chronic tinnitus
- The Synergistic Impact of Probiotics and Dietary Fiber on Constipation Management in Chlorpromazine-Induced Schizophrenia Patients: Exploring the Modulation of Intestinal Microbiota and Neurotrophic Factors
- Serum metabolomics analysis combined with network pharmacology reveals possible mechanisms of postoperative cognitive dysfunction in the treatment of Mongolian medicine Eerdun Wurile basic formula
- Photobiomodulation's Potential as a Non-Invasive Therapy for Alzheimer's disease and Minimal Cognitive Impairment: A 12-Week Investigation
- Physiological and biochemical in vivo study of polyphenols and 20-hydroxyecdisone from quinoa grains effect on resistance to physical exercise in Wistar rats
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Correction to tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
- Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment
- Proactive Versus Reactive Control Strategies Differentially Mediate Alcohol Drinking in Male Wistar and P rats
- Peripheral amyloid-beta clearance mediates cognitive impairment in non-alcoholic fatty liver disease
- The Effects of Health Education and the Sunrise Model of Nursing Care on Blood Pressure Control and Psychological Status in Elderly Patients with Hypertension
- Effect of acupuncture for temporomandibular disorders: a randomized clinical trial
- Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats
- Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder
- Assessment of Mild Cognitive Impairment Using CogEvo: A Computerized Cognitive Function Assessment Tool
- Transcranial direct current stimulation combined with swimming exercise improves the learning and memory abilities of vascular dementia rats by regulating microglia through miR-223-3p/PRMT8
- Efficacy evaluation of Mongolian medical warm acupuncture for sciatica caused by lumbar disc herniation: a randomized, controlled, single-blind clinical trial
- Positive psychotic symptoms as a marker of clinical severity in a transdiagnostic sample of help-seeking adolescents
- Sex-specific neuropsychological correlates of apathy and depression across neurodegenerative disorders
- Serum Galectin-1, Galectin-9, and YKL-40 levels in bipolar disorder and their relationship with cognitive functions
- Neonatal Isolation Increases the Susceptibility to Learned Helplessness through the Aberrant Neuronal Activity in the Ventral Pallidum of Rats
- Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats
- Usage of two novel dyes to enhance visualisation of cut ends of the vessel in microvascular anastomosis - An experimental study in 45 rats
Evidence Blueprint
GPR30 agonist G1 combined with hypothermia alleviates cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage in rats
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
GPR30 agonist G1 combined with hypothermia alleviates cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage in rats
🌐 365 Days
VR Related Evidence Matrix
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
- Subarachnoid Hemorrhage Trials: Cutting, Sliding, or Keeping mRS Scores and WFNS Grades
- S100A9 aggravates early brain injury after subarachnoid hemorrhage via inducing neuroinflammation and inflammasome activation
- Neurobehavioral Impairments Predict Specific Cerebral Damage in Rat Model of Subarachnoid Hemorrhage
- Subarachnoid Hemorrhage Confirmed by Magnetic Resonance Imaging in a Patient with Brain Death owing to Hypoxic Encephalopathy Following Suicide by Hanging
- Subarachnoid hemorrhage due to pituitary adenoma apoplexy-case report and review of the literature
- Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis
- The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury
- The effect of induced hypertension in aneurysmal subarachnoid hemorrhage: A narrative review
- Differentiating between Mycotic and Dissecting Aneurysms in a Case of Ruptured Distal Superior Cerebral Artery Aneurysm
- Effects of carbamazepine on BDNF expression in trigeminal ganglia and serum in rats with trigeminal neuralgia
- Examining strength at home couples to prevent intimate partner violence on a military installation: A randomized controlled trial
- Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage
- Granulocyte colony-stimulating factor plus pentoxifylline increases short-term survival in patients with severe alcoholic hepatitis: a network meta-analysis
- Changing Patterns of Stroke and Subtypes Attributable to High Systolic Blood Pressure in China From 1990 to 2019
- Hypo-attenuating Berry Sign as a Novel Imaging Marker of Ruptured Aneurysm in Patients with Subarachnoid Hemorrhage; a Diagnostic Accuracy Study
- MiR-21-5p alleviates trigeminal neuralgia in rats through down-regulation of voltage-gated potassium channel Kv1.1
- Randomized-controlled trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis
- Acute low dose caffeine affects behavior profile and activity, an examination of male rats with high or low anxiety-like behavior
- The effects of Spirulina platensis on behavior in adolescent rats fed a high-fat diet
- Fucoidan protects CA1 pyramidal neurons of the hippocampus and preserves the cognitive profile of rats subjected to transient forebrain ischemia
- Clinical characteristics and prognosis of hospitalized patients with moderate alcohol-associated hepatitis
- Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression- and anxiety-like behaviors but different corticosterone and endocannabinoid system modulation
- Neurologic Injury-Related Predisposing Factors of Post-Traumatic Stress Disorder: A Critical Examination
- Effect of leuprolide acetate, a GnRH agonist, on neuroinflammation and anxiety-like behavior after mild hypoxic-ischemic encephalopathy in rat model
- Isolated spinal artery aneurysm: etiology, clinical characteristics, and outcomes
- Isolated spinal artery aneurysm: etiology, clinical characteristics, and outcomes
- Systemic Administration of Porphyromonas Gingivalis Lipopolysaccharide Induces Glial Activation and Depressive-Like Behavior in Rats
- Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats
- Intravenous Injection of GluR2-3Y Inhibits Repeated Morphine-Primed Reinstatement of Drug Seeking in Rats
- Function and mechanism exploring of icariin in schizophrenia through network pharmacology
- Repair effect of different doses of human umbilical cord mesenchymal stem cells on white matter injury in neonatal rats
- Brazil Nut-Enriched Diet Modulates Enteric Glial Cells and Gut Microbiota in an Experimental Model of Chronic Kidney Disease
- Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A(1) Receptor Agonist and Body Cooling
- Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A(1) Receptor Agonist and Body Cooling
- Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury
- The ameliorative effect of midazolam on empathy-like behavior in old rats
- Effects of chronic social equality and inequality conditions on passive avoidance memory and PTSD-like behaviors in rats under chronic empathic stress
- Aqueous extract of pummelo pulp (Citrus maxima) improves the biochemical profile and reduces the inflammation process in Wistar rats with non-alcoholic fatty liver disease
- Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis
- Clinical Efficacy of Sun's Abdominal Acupuncture Combined with CBTI in Treating Chronic Insomnia with Anxiety
- The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration
- Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
- Dexmedetomidine Alleviates Ischemia/Reperfusion-Associated Acute Kidney Injury by Enhancing Autophagic Activity via the α2-AR/AMPK/mTOR Pathway
- The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field
- Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat
- Targeted visual cortex stimulation (TVCS): a novel neuro-navigated repetitive transcranial magnetic stimulation mode for improving cognitive function in bipolar disorder
- Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model
- G protein-coupled estrogen receptor (GPER) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism
- Polyethylene Glycol Fusion Restores Axonal Continuity and Improves Return of Function in a Rat Median Nerve Denervation Model
- Age-Related Changes in Glutamic Acid Decarboxylase 1 Gene Expression in the Medial Prefrontal Cortex and Ventral Hippocampus of Fear-Potentiated Rats Subjected to Isolation Stress
- Melatonin Ameliorates Neuropsychiatric Behaviors, Gut Microbiome, and Microbiota-Derived Metabolites in Rats with Chronic Sleep Deprivation
- Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
- Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
- Anodal HD-tDCS on the dominant anterior temporal lobe and dorsolateral prefrontal cortex: clinical results in patients with mild cognitive impairment
- Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet
- Gestational administration of vitamin D improves maternal care and prevents anxiety-like behavior in male and female Wistar rats prenatally exposed to dexamethasone
- Sex-related beneficial effects of exercise on cardiac function and rhythm in autistic rats
- Neuroprotective effects of quinpirole on lithium chloride pilocarpine-induced epilepsy in rats and its underlying mechanisms
- A quantitative and T-pattern analysis of anxiety-like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests
- Rosiglitazone Promotes Microglial Distribution via Activation of PPARγ and CD36 in the ICH Rat Model
- Effect of biofeedback intervention on neurological characteristics of children with attention deficit hyperactivity disorder
- Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior
- Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase