Evidence
Int J Neuropsychopharmacol. 2024 Feb 19:pyae011. doi: 10.1093/ijnp/pyae011. Online ahead of print.
ABSTRACT
BACKGROUND: The histamine-3 receptor (H3R) may have a role in cognitive processes, through its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To explore this, we examined anterior cingulate cortex (ACC) and striatum H3R availability in patients with schizophrenia, and characterised their relationships with glutamate levels in corresponding brain regions.
METHODS: We employed a cross-sectional study, recruiting 12 patients with schizophrenia and 12 healthy volunteers. Participants underwent positron emission tomography (PET) using the H3R-specific radio ligand [11C]MK-8278, followed by proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate levels, recorded as Glu and Glx. Based on existing literature, the ACC and striatum were selected as regions of interest (ROIs).
RESULTS: We found significant inverse relationships between tracer uptake and Glu (r = -0.66, p = 0.02) and Glx (r = -0.62, p = 0.04) levels in the ACC of patients, which were absent in healthy volunteers (Glu: r = -0.19, p = 0.56, Glx: r = 0.10, p = 0.75). We also found a significant difference in striatal (F1,20 = 6.00, p = 0.02) and ACC (F1,19 = 4.75, p = 0.04) Glx levels between groups.
CONCLUSIONS: These results provide evidence of a regionally specific relationship between H3Rs and glutamate levels, which builds on existing pre-clinical literature. Our findings add to a growing literature indicating H3Rs may be a promising treatment target in schizophrenia, particularly for cognitive impairment, which has been associated with altered glutamate signalling.
PMID:38373256 | DOI:10.1093/ijnp/pyae011
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Histamine-3 receptor availability and glutamate levels in the brain: a PET-1H-MRS study of patients with schizophrenia and healthy controls
🌐 90 Days
Evidence Blueprint
Histamine-3 receptor availability and glutamate levels in the brain: a PET-1H-MRS study of patients with schizophrenia and healthy controls
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence