Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
J Int Med Res. 2024 Jun;52(6):3000605241258473. doi: 10.1177/03000605241258473.
ABSTRACT
The aim of this short narrative review was to evaluate the existing literature regarding the clinical use of ketamine among individuals with dementia, especially those with behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, and MEDLINE) databases were searched for abstracts using the search terms “ketamine” AND “dementia.” Only articles describing the use of ketamine in individuals with dementia were included. Articles that did not include individuals with dementia, did not use ketamine, were published in a non-English language, primarily described animal studies, or were reviews were excluded. Three case reports met the inclusion criteria. One described the use of subcutaneous ketamine for depression, one described the use of intramuscular ketamine for acute agitation, and one described the use of S-ketamine as anesthesia during electroconvulsive therapy for depression and catatonia. No significant adverse effects were reported in any of the cases. Although the use of ketamine in the treatment of depression and agitation associated with dementia has potential, the current evidence remains limited. High-quality prospective studies are needed to confirm the observations of these case reports before ketamine can be used to treat behavioral disturbances in individuals with dementia.
PMID:38907362 | DOI:10.1177/03000605241258473
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Is there evidence for using ketamine among individuals with dementia?
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Exploring the Impact of Music on Response to Ketamine/Esketamine: A Scoping Review Ketamine for mood disorders, anxiety, and suicidality in children and adolescents: a systematic review Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? A meta-analysis of the effects of ketamine on suicidal ideation in depression patients The Pharmacological Management of Ketamine Use Disorder: A Systematic Review Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression Long-term follow-up of participants in ketamine clinical trials for mood disorders Current concepts in ketamine therapy in the emergency department Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis Exploring the influence of weather variability and climate change on health outcomes in people living with dementia: A scoping review protocol Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study Widespread reductions in cortical thickness following ketamine abuse Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Ketamine in the effective management of chronic pain, depression, and posttraumatic stress disorder for Veterans: A meta-analysis and systematic review The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community The role and impact of therapeutic counselling on the emotional experience of adults living with dementia: A systematic review Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression The current status of apathy in patients with dementia and its factors: A systematic review Diabetes mellitus and risk of incident dementia in APOE e4 carriers: an updated meta-analysis Effectiveness of interventions to prevent abuse in people living with dementia in community settings: A systematic review Metformin mitigates dementia risk among individuals with type 2 diabetes Subanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats Perimenopausal physical activity and dementia risk: A systematic review Improvement in depressive symptoms in a patient with severe and enduring anorexia nervosa and comorbid major depressive disorder using psychotherapy-assisted IV ketamine : a case report Out-of-hospital paramedic interactions with people living with dementia: a scoping review Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies Loneliness and social isolation among informal carers of individuals with dementia: A systematic review and meta-analysis Usability of web-based tools designed for communication and decision-making in dementia: Systematic review and design brief Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis Mentalising imagery therapy for family dementia caregivers: protocol for a scoping review Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors Virtual reality-based dementia educational programmes for formal and informal caregivers of people with dementia: A scoping review Heat-related illness and dementia: a study integrating epidemiological and experimental evidence Exploring self-experience practices in dementia care: A scoping review Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report Alcohol Use Disorder and Dementia: A Review Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3beta interaction Barriers and facilitators to diagnosing dementia in migrant populations: A systematic review of European health professionals' perspectives Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Denial of Desire for Death in Dementia: Why Is Dementia Excluded from Australian Voluntary Assisted Dying Legislation? Denial of Desire for Death in Dementia: Why Is Dementia Excluded from Australian Voluntary Assisted Dying Legislation? Association between chronic pain and dementia: a systematic review and meta-analysis A Meta-Synthesis on Sexuality in Persons with Dementia Mapped Using the Model of Human Occupation Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy Subcutaneous ketamine reduces suicide risk and improves functioning in depression: A proof-of-concept study Cognitive impairment, neurodegenerative disorders, and olfactory impairment: A literature review Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies Incidence and prevalence of dementia: A 2015-2020 population-based study in the Campania Region of Italy Characteristics, outcomes, facilitators and barriers for psychosocial interventions on inpatient mental health dementia wards: a systematic review Characteristics, outcomes, facilitators and barriers for psychosocial interventions on inpatient mental health dementia wards: a systematic review Obsessive-Compulsive Symptoms in Dementia: Scoping Review of Pathological Changes Risk of dementia and Alzheimer's disease associated with antidiabetics: A Bayesian network meta-analysis
Evidence Blueprint
Is there evidence for using ketamine among individuals with dementia?
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Is there evidence for using ketamine among individuals with dementia?
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Exploring the Impact of Music on Response to Ketamine/Esketamine: A Scoping Review Ketamine use in pediatric depression: A systematic review The Efficacy and Safety of Intranasal Formulations of Ketamine and Esketamine for the Treatment of Major Depressive Disorder: A Systematic Review Newer therapies and surgical management of ketamine-induced uropathy: A review Ketamine for mood disorders, anxiety, and suicidality in children and adolescents: a systematic review Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Ketamine, an Old-New Drug: Uses and Abuses Are Population-Level Approaches to Dementia Risk Reduction Under-Researched? A Rapid Review of the Dementia Prevention Literature A meta-analysis of the effects of ketamine on suicidal ideation in depression patients Intravenous Ketamine Exacerbating Symptoms of Acute Stress Disorder: A Case Report and Systematized Review of Existing Literature The Pharmacological Management of Ketamine Use Disorder: A Systematic Review Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression Long-term follow-up of participants in ketamine clinical trials for mood disorders Similarities and differences in the prevalence and risk factors of suicidal behavior between caregivers and people with dementia: a systematic review Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects? Self- and Proxy-Completion of Quality of Life Assessment in Dementia Care: A Review of Reviews Current concepts in ketamine therapy in the emergency department Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis Brain-derived neurotrophic factor Val66Met and CYP2B6 polymorphisms as predictors for ketamine effectiveness in patients with treatment-resistant depression Exploring the influence of weather variability and climate change on health outcomes in people living with dementia: A scoping review protocol A scoping review on the psychosocial interventions used in day care service for people living with dementia Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study Depression as a Risk Factor for Dementia: A Meta-Analysis Ketamine for treatment-resistant major depressive disorder: Double-blind active-controlled crossover study Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics? (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice Primitive reflexes and dementia in older adults: a meta-analysis of observational and cohort studies Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality Short-term ketamine use in bipolar depression: a review of the evidence for short-term treatment management So how special is special K? A systematic review and meta-analysis of ketamine for PTSD RCTs Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta-analysis Current trends in psychotherapies and psychosocial interventions for people with dementia: a scoping review of randomized controlled trials Current trends in psychotherapies and psychosocial interventions for people with dementia: a scoping review of randomized controlled trials Widespread reductions in cortical thickness following ketamine abuse Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network Dental decision-making for persons with dementia: A systematic narrative review Ketamine in the effective management of chronic pain, depression, and posttraumatic stress disorder for Veterans: A meta-analysis and systematic review Equine-assisted services for people living with dementia: a systematic review Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies Dilemmas and support strategies in dementia care: Experiences of case managers in Taiwan The role and impact of therapeutic counselling on the emotional experience of adults living with dementia: A systematic review Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Long-term quality of life after repeated ketamine infusions in anxious and nonanxious patients with depression Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression The current status of apathy in patients with dementia and its factors: A systematic review Diabetes mellitus and risk of incident dementia in APOE e4 carriers: an updated meta-analysis Impact of sleep duration and sleep disturbances on the incidence of dementia and Alzheimer's disease: A 10-year follow-up study Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study Diagnosis of Alzheimer's dementia and vehicle driving restriction: a scoping review Effectiveness of interventions to prevent abuse in people living with dementia in community settings: A systematic review Caring for people with dementia from culturally and linguistically diverse backgrounds in nursing homes: A scoping review Effectiveness of Ketamine for the Treatment of Post-Traumatic Stress Disorder - A Systematic Review and Meta-Analysis