Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Neurosci Bull. 2024 Jul 9. doi: 10.1007/s12264-024-01252-9. Online ahead of print.
ABSTRACT
Obsessive-compulsive disorder (OCD) is a chronic, severe psychiatric disorder that has been ranked by the World Health Organization as one of the leading causes of illness-related disability, and first-line interventions are limited in efficacy and have side-effect issues. However, the exact pathophysiology underlying this complex, heterogeneous disorder remains unknown. This scenario is now rapidly changing due to the advancement of powerful technologies that can be used to verify the function of the specific gene and dissect the neural circuits underlying the neurobiology of OCD in rodents. Genetic and circuit-specific manipulation in rodents has provided important insights into the neurobiology of OCD by identifying the molecular, cellular, and circuit events that induce OCD-like behaviors. This review will highlight recent progress specifically toward classic genetic animal models and advanced neural circuit findings, which provide theoretical evidence for targeted intervention on specific molecular, cellular, and neural circuit events.
PMID:38982026 | DOI:10.1007/s12264-024-01252-9
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study The genetics of trichotillomania and excoriation disorder: A systematic review Neurobiology and Treatment of Posttraumatic Stress Disorder iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation Phenotypes of autism spectrum disorder and schizoaffective disorder associated with SETD1B gene but without intellectual disability and seizures Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance Resting-state functional connectivity of amygdala subregions across different symptom subtypes of obsessive-compulsive disorder patients Psilocybin in pharmacotherapy of obsessive-compulsive disorder Chronic stress alters synaptic I/E balance of pyramidal neurons but not PV interneurons in the infralimbic and prelimbic cortices of C57BL/6J mice Omics approaches to investigate the pathogenesis of suicide Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: Insights gained from selective targeting of the subthalamic nucleus, para-subthalamic nucleus and zona incerta in rodents Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia Emerging X-linked genes associated with neurodevelopmental disorders in females Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View WONOEP appraisal: Modeling early onset epilepsies Pre- And Post-Synaptic Protein In The Major Depressive Disorder: From Neurobiology To Therapeutic Targets Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective STXBP1: fast-forward to a brighter future - a patient organization perspective Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients Case report: Early use of whole exome sequencing unveils HNRNPU-related neurodevelopmental disorder and answers additional clinical questions through reanalysis Case report: Early use of whole exome sequencing unveils HNRNPU-related neurodevelopmental disorder and answers additional clinical questions through reanalysis Diverse clinical presentation of SPTBN1 variants: Complex versus primary attention-deficit/hyperactivity disorder Diverse clinical presentation of SPTBN1 variants: Complex versus primary attention-deficit/hyperactivity disorder Risks of developing major psychiatric disorders among child and adolescent intensive care unit survivors Risks of developing major psychiatric disorders among child and adolescent intensive care unit survivors Scoping Review of Acceptance and Commitment Therapy for Obsessive-Compulsive Disorder in Iran Genetic neurodevelopmental clustering and dyslexia Genetic neurodevelopmental clustering and dyslexia Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer's Disease From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer's Disease Development of an eye-tracking system based on a deep learning model to assess executive function in patients with mental illnesses Development of an eye-tracking system based on a deep learning model to assess executive function in patients with mental illnesses A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals Assessing the effectiveness of high-definition transcranial direct current stimulation for treating obsessive-compulsive disorder: Results from a randomized, double-blind, controlled trial Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function Affective visual circuit dysfunction in trauma and stress-related disorders Correlation of Comorbidities and Variability of Tics in Children with Chronic Tic Disorder Expectation of pain and relief: a dynamical model of the neural basis for pain-trauma co-morbidity The relationship between parental obsessive-compulsive disorder and children's cognitive disengagement syndrome (Sluggish Cognitive Tempo) The link between alterations in circadian rhythms and lipid metabolism in bipolar disorder: the lipid droplets hypothesis Inhibitory systems in brain evolution: pathways of vulnerability in neurodevelopmental disorders The status of MRI databases across the world focused on psychiatric and neurological disorders The status of MRI databases across the world focused on psychiatric and neurological disorders Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients Abnormal structure and function of white matter in obsessive-compulsive disorder Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
Evidence Blueprint
Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder Spatiotemporal expression patterns of anxiety disorder-associated genes From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function Theta and Gamma Activity Differences in Obsessive-Compulsive Disorder and Panic Disorder: Insights from Resting-State EEG with eLORETA White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder Predictive Processing and the Pathophysiology of Functional Neurological Disorder Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination Rodent models for mood disorders - understanding molecular changes by investigating social behavior Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci The current state, challenges, and future directions of deep brain stimulation for obsessive compulsive disorder Clinical Advances in Treatment Strategies for Obsessive-compulsive Disorder in Adults Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia The genetics of trichotillomania and excoriation disorder: A systematic review A closer look to neural pathways and psychopharmacology of obsessive compulsive disorder Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder Evidence-Based Supported Employment for Individuals With Obsessive-Compulsive Disorder Family accommodation in obsessive-compulsive disorder: an updated systematic review and meta-analysis Neurobiology and Treatment of Posttraumatic Stress Disorder The shared genetic risk factors between Tourette syndrome and obsessive-compulsive disorder Epilepsy and psychiatric comorbidities: A bidirectional mendelian randomization study Application of Hybrid DeepLearning Architectures for Identification of Individuals with Obsessive Compulsive Disorder Based on EEG Data iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders The clinical presentation of major depressive disorder in youth with co-occurring obsessive-compulsive disorder Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment Schizophrenia: from neurochemistry to circuits, symptoms and treatments Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice Intensive exposure treatment for obsessive compulsive disorder in old age. Progress and Implications from Genetic Studies of Bipolar Disorder Clinical features in co-occuring obsessive-compulsive disorder and bipolar disorder: A systematic review and meta-analysis Overcoming genetic and cellular complexity to study the pathophysiology of X-linked intellectual disabilities Neural Cell-types and Circuits Linking Thermoregulation and Social Behavior Neural Cell-types and Circuits Linking Thermoregulation and Social Behavior Temperament Traits in Pediatric Obsessive-Compulsive Disorder in Relation to Tourette Syndrome and Attention-Deficit Hyperactivity Disorder Is tuberous sclerosis complex-associated autism a preventable and treatable disorder? Phenotypes of autism spectrum disorder and schizoaffective disorder associated with SETD1B gene but without intellectual disability and seizures Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD) Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance Temporal dynamics of autonomic nervous system responses under cognitive-emotional workload in obsessive-compulsive disorder Clinical efficacy of deep transcranial magnetic stimulation (dTMS) in psychiatric and cognitive disorders: A systematic review Resting-state functional connectivity of amygdala subregions across different symptom subtypes of obsessive-compulsive disorder patients Obsessive-Compulsive Disorder (OCD): A Comprehensive Review of Diagnosis, Comorbidities, and Treatment Approaches Psilocybin in pharmacotherapy of obsessive-compulsive disorder "This Is a Disease" and "Disease Has No Sin": Discourse Constructions of Individuals With Obsessive-Compulsive Disorder With Regard to Being Diagnosed Forebrain EAAT3 overexpression increases susceptibility to amphetamine-induced repetitive behaviors Chronic stress alters synaptic I/E balance of pyramidal neurons but not PV interneurons in the infralimbic and prelimbic cortices of C57BL/6J mice Neurosurgical neuromodulation therapy for psychiatric disorders Omics approaches to investigate the pathogenesis of suicide Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder