Evidence
Nat Genet. 2024 Apr 18. doi: 10.1038/s41588-024-01707-9. Online ahead of print.
ABSTRACT
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
PMID:38637617 | DOI:10.1038/s41588-024-01707-9
Add to Google Keep
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
🌐 90 Days
VR Related Evidence Matrix
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
- Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
- Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation
- The causal relationship of female infertility and psychiatric disorders in the European population: a bidirectional two-sample Mendelian randomization study
- Genome-wide characterization of circulating metabolic biomarkers
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
- Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort
- Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci
- Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
- Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
- Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans
- Genome-wide association study identifies new loci associated with OCD
- Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders
- Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline
- Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
- Genetic and non-genetic predictors of risk for opioid dependence
- Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis
- The genetic architecture of multimodal human brain age
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia
- Identifying novel chemical-related susceptibility genes for five psychiatric disorders through integrating genome-wide association study and tissue-specific 3'aQTL annotation datasets
- Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
- Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder
- Genome-wide epistasis analysis reveals gene-gene interaction network on an intermediate endophenotype P-tau/Aβ42 ratio in ADNI cohort
- Genetic influences on circulating retinol and its relationship to human health
- Associations of externalizing polygenic scores with externalizing disorders among Mexican youth
- Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits
- Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits
- Neuropsychiatric disorders, chronotype and sleep: A narrative review of GWAS findings and the application of Mendelian randomization to investigate causal relationships
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder
- Potential causal association between gut microbiome and posttraumatic stress disorder
- A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
- Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging
- The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease
- No evidence for a causal contribution of bioavailable testosterone to ADHD in sex-combined and sex-specific two-sample Mendelian randomization studies
- Psychiatric Polygenic Risk Scores Across Youth With Bipolar Disorder, Youth at High Risk for Bipolar Disorder, and Controls
- Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
- Identifying genetic differences between bipolar disorder and major depression through multiple GWAS
- Genetic associations and potential mediators between psychiatric disorders and irritable bowel syndrome: a Mendelian randomization study with mediation analysis
- Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans
- Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
- Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
- Fine-mapping genomic loci refines bipolar disorder risk genes
- Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance
- Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia
- Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study
- Causal association between kynurenine and depression investigated using two-sample mendelian randomization
Evidence Blueprint
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
Save Evidence Blueprint
Save as PDF
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
🌐 365 Days
VR Related Evidence Matrix
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
- Multi-ancestry genome-wide association meta-analysis of Parkinson's disease
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders
- Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations
- Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants
- Cluster headache genome-wide association study and meta-analysis identifies eight loci and implicates smoking as causal risk factor
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
- Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism
- A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations
- Genetics of Alzheimer's Disease in the African American Population
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
- Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
- Genome-phenome wide association study of broadly defined headache
- Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus
- Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
- Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study
- Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits
- Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
- Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
- Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
- Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders
- The causal relationship of female infertility and psychiatric disorders in the European population: a bidirectional two-sample Mendelian randomization study
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
- Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
- Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine
- Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program
- Exploring genetic risk for catatonia in a genome wide association study and polygenic risk score analysis
- Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics
- Genome-wide characterization of circulating metabolic biomarkers
- Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
- Identifying genetic loci that are associated with changes in gene expression in PTSD in a South African cohort
- Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
- Common genetic variants contribute to heritability of age at onset of schizophrenia
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control
- The collaborative study on the genetics of alcoholism: Genetics
- Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
- Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders
- CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
- Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
- Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study
- Genetic correlation, shared loci, but no causality between bipolar disorder and inflammatory bowel disease: A genome-wide pleiotropic analysis
- Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci
- Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort
- Shared genetic architectures of educational attainment in East Asian and European populations
- Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci
- Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals
- Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
- Genome-wide association studies: Utility and limitations for research in physiology
- Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population