Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Clin Geriatr Med. 2023 Feb;39(1):91-107. doi: 10.1016/j.cger.2022.07.005. Epub 2022 Oct 18.
ABSTRACT
Dementias encompass a range of debilitating neurologic conditions. Here, we summarize the neuropathology of common forms of dementia, focusing on Alzheimer disease (AD) and related dementias. AD is part of a spectrum of neurodegenerative diseases that consists of various protein inclusions (ie, proteinopathies) but other brain abnormalities are also related to dementia. Beta-amyloid and tau aggregates are hallmarks of AD. Other tissue substrates include Lewy bodies, TDP-43 inclusions, vascular brain lesions, and mixed pathologies. This review highlights the complexity of neurodegenerative and other disease substrates and summarizes topography of these lesions and concepts of mixed brain pathologies, resistance, and resilience.
PMID:36404035 | DOI:10.1016/j.cger.2022.07.005
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 2 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Neuropathology of the Common Forms of Dementia
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology Influences of amyloid-beta and tau on white matter neurite alterations in dementia with Lewy bodies Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies When prion disease Isn't suspected: prion disease as the cause of terminal decline in chronic mixed dementia Ageing-Related Neurodegeneration and Cognitive Decline Exploring Psychosis in Neurodegenerative Dementia: Connecting Symptoms to Neurobiology G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domain In vivo PET classification of tau pathologies in patients with frontotemporal dementia Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes Multiple system atrophy with amyloid-b-predominant Alzheimer's disease neuropathologic change PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions Neuropsychiatric symptoms profile and markers of Alzheimer disease-type pathology in patients with Lewy body dementias Biomarkers of Neurodegeneration and Alzheimer's Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study Lecanemab blocks the effects of the Ab/fibrinogen complex on blood clots and synapse toxicity in organotypic culture Innate immune activation in neurodegenerative diseases Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology Psychosis in Neurodegenerative Dementias: A Systematic Comparative Review Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis The effects of cholesterol and statins on Parkinson's neuropathology: a narrative review Production and characterization of novel monoclonal antibodies against pathological human TDP-43 proteins Association of Alzheimer's Disease and Other Neuropathologies with Functional Disability in Persons With and Without Dementia Unraveling the Dual Role of ADAM10: Bridging the Gap between Cancer and Alzheimer's Disease Peripheral vascular dysfunction and the aging brain Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy Nonpharmacological intervention therapies for dementia: potential break-even intervention price and savings for selected risk factors in the European healthcare system Postacute Care and Long-term Care for LGBTQ+ Older Adults Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain P2Y1 receptor in Alzheimer's disease Alcohol Use Disorder and Dementia: A Review Genomic stress and impaired DNA repair in Alzheimer disease A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models Prevalence and Determinants of Diagnosed Dementia: A Registry Linkage Study Linking Diagnosis of Dementia in the Population-Based HUNT Study to Registry Diagnosis of Dementia in Primary Care and Hospitals in Norway Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides Reduced STMN2 and pathogenic TDP-43, two hallmarks of ALS, synergize to accelerate motor decline in mice Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43 Blood biomarkers open a window to brain pathophysiology in Alzheimer's disease Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis Pimavanserin's Safety Profile: Insights from a Phase 3b Clinical Trial Differences in cognitive trajectories of dementia: Comparison Alzheimer's disease dementia and Dementia with Lewy bodies in Korean patient cohort Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?
Evidence Blueprint
Neuropathology of the Common Forms of Dementia
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Neuropathology of the Common Forms of Dementia
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exception Targeted examination of amyloid beta and tau protein accumulation via positron emission tomography for the differential diagnosis of Alzheimer's disease based on the A/T(N) research framework Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration Influences of amyloid-beta and tau on white matter neurite alterations in dementia with Lewy bodies Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies Polypathologic associations with grey matter atrophy in neurodegenerative disease Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry Ischemia-Reperfusion Programming of Alzheimer's Disease-Related Genes-A New Perspective on Brain Neurodegeneration after Cardiac Arrest Pathophysiology of dementia Senile plaque-associated transactive response DNA-binding protein 43 in Alzheimer's disease: A case report spanning 16 years of memory loss When prion disease Isn't suspected: prion disease as the cause of terminal decline in chronic mixed dementia Autophagy Markers Are Altered in Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia Relative contributions of mixed pathologies to cognitive and functional symptoms in brain donors exposed to repetitive head impacts Ageing-Related Neurodegeneration and Cognitive Decline Elucidating distinct molecular signatures of Lewy body dementias Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies TDP-43 and Alzheimer's Disease Pathology in the Brain of a Harbor Porpoise Exposed to the Cyanobacterial Toxin BMAA Exploring Psychosis in Neurodegenerative Dementia: Connecting Symptoms to Neurobiology The Relationship Between First Presenting Neuropsychiatric Symptoms in Older Adults and Autopsy-Confirmed Memory Disorders G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease Disrupting pathologic phase transitions in neurodegeneration Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles Pathological Markers of Alzheimer's Disease and Related Dementia in the Rhesus Macaque Amygdala Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domain Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia: Dementia Series Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD In vivo PET classification of tau pathologies in patients with frontotemporal dementia Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells Alzheimer's disease biomarker analysis using targeted mass spectrometry Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease Traumatic Brain Injury in Mice Generates Early-Stage Alzheimer's Disease Related Protein Pathology that Correlates with Neurobehavioral Deficits Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies A data-driven study of Alzheimer's disease related amyloid and tau pathology progression Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies Age-related hearing loss and dementia-related neuropathology: An analysis of the United Kingdom brains for dementia research cohort Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation Dem-Aging: autophagy-related pathologies and the "two faces of dementia" Dementia with Lewy bodies: old and new knowledge - Part 1: clinical aspects and diagnostics Identifying Mixed Dementia With Lewy Bodies and Alzheimer Disease Using Multitracer PET Imaging: A Case Study Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia Neuropathology of Alzheimer's Disease Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia 9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models 9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models