Evidence
Eur J Hybrid Imaging. 2022 Nov 21;6(1):26. doi: 10.1186/s41824-022-00145-2.
ABSTRACT
BACKGROUND: Recent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [99mTc]Tc-ECD brain SPECT and correlated rCBF findings with the numeric rating scale (NRS) of pain and douleur neuropathique en 4 questions (DN4). Ten healthy control volunteers and fourteen patients with neuropathic CLBP due to lumbar disc herniation underwent cerebral SPECT scans. A quantitative comparison of rCBF findings between patients and controls was made using the Statistical Parametric Mapping (SPM), revealing clusters of voxels with a significant increase or decrease in rCBF. The intensity of CLBP was assessed by NRS and by DN4.
RESULTS: The results demonstrated an rCBF increase in clusters A (occipital and posterior cingulate cortex) and B (right frontal) and a decrease in cluster C (superior parietal lobe and middle cingulate cortex). NRS scores were inversely and moderately correlated with the intensity of rCBF increase in cluster B, but not to rCBF changes in clusters A and C. DN4 scores did not correlate with rCBF changes in all three clusters.
CONCLUSIONS: This study will be important for future therapeutic studies that aim to validate the association of rCBF findings with the pharmacokinetic and pharmacodynamic profiles of therapeutic challenges in pain.
PMID:36404393 | DOI:10.1186/s41824-022-00145-2
Add to Google Keep
Estimated reading time: 5 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study
🌐 90 Days
VR Related Evidence Matrix
- Evolving role of viadisc for chronic low back and discogenic pain: a narrative review
- Reduction of chronic primary low back pain by spinal manipulative therapy is accompanied by decreases in segmental mechanical hyperalgesia and pain catastrophizing: a randomized placebo-controlled dual-blind mixed experimental trial
- Machine Learning Models for Predicting Disability and Pain Following Lumbar Disc Herniation Surgery
- HADS and SOMS-2 brief score evaluation can prevent unnecessary minimal invasive spine interventions - a prospective blinded observational clinical trial
- HADS and SOMS-2 brief score evaluation can prevent unnecessary minimal invasive spine interventions - a prospective blinded observational clinical trial
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- Altered central pain processing in patients with degenerative lumbar diseases and its association with low physical activity levels after lumbar spinal surgeries: a retrospective cohort analysis
- Risk of Unfavorable Trajectories of Chronic Pain Severity - Results of a Longitudinal Study in School Children
- Biopsychosocial rehabilitation in the working population with chronic low back pain: a concept analysis
- Five-Year Longitudinal Follow-up of Restorative Neurostimulation Shows Durability of Effectiveness in Patients With Refractory Chronic Low Back Pain Associated With Multifidus Muscle Dysfunction
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain
- The relationship of depressive symptoms with pain and analgesic use in Turkish adolescents
- Subgroups of pelvic pain are differentially associated with endometriosis and inflammatory comorbidities: a latent class analysis
- Chronic pain in pediatric patients: epidemiology, pathophysiology, and mitigation strategies
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder
- Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
- 99mTc-HMPAO SPECT Perfusion Signatures Associated With Clinical Progression in Patients With Isolated REM Sleep Behavior Disorder
- Mechanisms of pain in aging and age-related conditions: focus on caregivers
- A Single-Session, 2-Hour Version of Mindfulness-Oriented Recovery Enhancement (One MORE) Improves Chronic Pain Patients' Pain-Related Outcomes Through 3-Month Follow-Up in a Randomized Controlled Trial
- Peer victimization, posttraumatic stress symptoms, and chronic pain: A longitudinal examination
- Pain and Post-traumatic Stress Disorder Symptoms: Dyadic Relationships Between Canadian Armed Forces Members/Veterans with Chronic Pain and their Offspring
- Impact of Early-Life Adversity on Cannabis Use: Exploring the Mediating and Moderating Effects of Chronic Pain
- Childhood Reading Ability and Pain in Childhood through to Midlife
- Childhood Reading Ability and Pain in Childhood through to Midlife
- Astrocyte Activation in the ACC Contributes to Comorbid Anxiety in Chronic Inflammatory Pain and Involves in The Excitation-Inhibition Imbalance
- Why don't we use a body map in every chronic pain patient yet?
- Understanding the impacts of chronic pain on autistic adolescents and effective pain management: a reflexive thematic analysis adolescent-maternal dyadic study
- Anxiety, pain catastrophizing, and pain outcomes among older adults with chronic orofacial pain
- Evaluating the Diagnostic Efficacy of 99mTc-Methionine Single-Photon Emission Computed Tomography-Computed Tomography: A Head-to-Head Comparison with 11C-Methionine Positron Emission Tomography-Magnetic Resonance Imaging in Glioma Patients
- Functional and Structural Abnormalities in the Pain Network of Generalized Anxiety Disorder Patients with Pain Symptoms
- Association of chronic pain with suicide attempt and death by suicide: a two-sample Mendelian randomization
- Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems
- Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease
- Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease
- Healthy women show more experimentally induced central sensitization compared with men
- Does the presence of chronic pain affect scores on cognitive screening tests/brief cognitive measures for dementia? A systematic review and meta-analysis
- Phenotypical characterization of exteroceptive sensation and pain symptoms on diabetic patients
- A randomized controlled trial: The efficacy and safety of Bushen Huoxue formula in the management of lower back pain from lumbar disc herniation
- Emotion Regulation and Psychological Dependence on Pain Medication among Hospital Outpatients with Chronic Spinal Pain: The Influence of Rumination about Pain and Alexithymia
- The mediating role of posttraumatic stress disorder symptoms in pain cognitions among Veterans with chronic pain
- Relationship between insomnia and pain in patients with chronic orofacial pain
- Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
- Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
- Neuropathic Pain, Mood, and Stress-Related Disorders: A Literature Review of Comorbidity and Co-Pathogenesis
- Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
- Psychological Factors Can Affect the Clinical Outcome of Chemonucleolysis with Condoliase in Patients with Lumbar Disk Herniation
- Multilevel Pain Assessment with Functional Near-Infrared Spectroscopy: Evaluating ΔHBO2 and ΔHHB Measures for Comprehensive Analysis
- Applications of PET and SPECT in Patients with Autism Spectrum Disorder
- Pain in your day? Get sleep treatment anyway! The role of pain in insomnia treatment efficacy in women veterans
- Neural circuits regulating visceral pain
- Effectiveness of a specific follow up program for the management of the mental components of Post-ICU Syndrome and Chronic Pain After COVID-19 Infection: Results from the PAIN-COVID Randomized Clinical Trial
- Alcohol use and the pain system
- A Pathophysiological Approach for Selecting Medications to Treat Nociceptive and Neuropathic Pain in Servicemembers
- A Pathophysiological Approach for Selecting Medications to Treat Nociceptive and Neuropathic Pain in Servicemembers
- Pharmacodynamic effects following co-administration of cannabinoids and opioids: A scoping review of human experimental studies
- Evaluating Sensitization-Associated, Neuropathic-Like Symptoms and Psychological Factors in Patients with Interstitial Lung Disease
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- Psychosocial Outcomes of Pain and Pain Management in Adults with Osteogenesis Imperfecta: A Qualitative Study
- Systematic review and co-ordinate based meta-analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization
- Mental health comorbidities in workers' compensation patients and the effect on pain, disability, quality of life, and return to work after lumbar spine surgery
- Stepped Care for Patients to Optimize Whole Recovery (SC-POWR): An Effectiveness Trial Evaluating a Stepped Care Model for Individuals With Opioid Use Disorder and Chronic Pain
Evidence Blueprint
Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study
🌐 365 Days
VR Related Evidence Matrix
- Characterization and burden of localized back pain versus back pain with chronic overlapping pain conditions
- Towards data-driven biopsychosocial classification of non-specific chronic low back pain: a pilot study
- Efficacy and safety of extracorporeal shockwave therapy in chronic low back pain: a systematic review and meta-analysis of 632 patients
- Efficacy and safety of extracorporeal shockwave therapy in chronic low back pain: a systematic review and meta-analysis of 632 patients
- The effect of self-management techniques on relevant outcomes in chronic low back pain: A systematic review and meta-analysis
- Race, Ethnicity, and Belief in a Just World: Implications for Chronic Pain Acceptance Among Individuals with Chronic Low Back Pain
- Association of social isolation and loneliness with chronic low back pain among older adults: A cross-sectional study from Japan Gerontological Evaluation Study (JAGES)
- Case report: Remission of chronic low back pain and oral dysesthesia comorbid with attention deficit/hyperactivity disorder by treatment with atomoxetine and pramipexole
- Evolving role of viadisc for chronic low back and discogenic pain: a narrative review
- Multi-Trait Exome-Wide Association Study of Back Pain-Related Phenotypes
- Effectiveness of spinal manipulation and biopsychosocial self-management compared to medical care for low back pain: a randomized trial study protocol
- Reduction of chronic primary low back pain by spinal manipulative therapy is accompanied by decreases in segmental mechanical hyperalgesia and pain catastrophizing: a randomized placebo-controlled dual-blind mixed experimental trial
- The associations of depression, anxiety, and insomnia at baseline with disability at a five-year follow-up point among outpatients with chronic low back pain: a prospective cohort study
- Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model
- Machine Learning Models for Predicting Disability and Pain Following Lumbar Disc Herniation Surgery
- Comparative Study of Unilateral Biportal Endoscopic and Traditional Open Surgery in the Treatment of Lumbar Disc Herniation
- TRPA1 rare variants in chronic neuropathic and nociplastic pain patients
- Case Report: Guanfacine and methylphenidate improved chronic lower back pain in autosomal dominant polycystic kidney disease with comorbid attention deficit hyperactivity disorder and autism spectrum disorder
- Pain Reduction and Posture Alignment Improvement in Older Adults with Chronic Low Back Pain: A Novel Approach Using Spinal Thermal Massage Bed and Calf Pneumatic Cell Compression
- Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients
- The Influence of Pre-operative Pain and Anxiety on Acute Postoperative Pain in Cardiac Surgery Patients Undergoing Enhanced Recovery after Surgery
- The effect of a music-based caregiving intervention on pain intensity in nursing home patients with dementia. A cluster-randomized controlled study
- HADS and SOMS-2 brief score evaluation can prevent unnecessary minimal invasive spine interventions - a prospective blinded observational clinical trial
- HADS and SOMS-2 brief score evaluation can prevent unnecessary minimal invasive spine interventions - a prospective blinded observational clinical trial
- Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling
- THE DIAGNOSIS AND TREATMENT OF LOW BACK PAIN: Synopsis of the 2021 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
- Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- Impact of mental health components on the development of back pain in young adults with adolescent idiopathic scoliosis
- Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial
- School bullying and peer relationships in children with chronic pain
- The quality of care index for low back pain: a systematic analysis of the global burden of disease study 1990-2017
- Altered central pain processing in patients with degenerative lumbar diseases and its association with low physical activity levels after lumbar spinal surgeries: a retrospective cohort analysis
- Neuropathic pain in patients with primary knee osteoarthritis: A cross-sectional study
- Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain
- Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity
- Validation of the pediatric version of the Graded Chronic Pain Scale Revised in school-aged children and adolescents
- The influence of comorbidities on outcomes for older people with back pain: BACE-D cohort study
- Risk of Unfavorable Trajectories of Chronic Pain Severity - Results of a Longitudinal Study in School Children
- The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain
- Biopsychosocial rehabilitation in the working population with chronic low back pain: a concept analysis
- Five-Year Longitudinal Follow-up of Restorative Neurostimulation Shows Durability of Effectiveness in Patients With Refractory Chronic Low Back Pain Associated With Multifidus Muscle Dysfunction
- Morphological changes of the limbic system associated with acute and chronic low-back pain: A UK biobank imaging study
- Pain sensitivity after Roux-en-Y gastric bypass - associations with chronic abdominal pain and psychosocial aspects
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain
- Machine Learning Based Linking of Patient Reported Outcome Measures to WHO International Classification of Functioning, Disability, and Health Activity/Participation Categories
- First-in-human prediction of chronic pain state using intracranial neural biomarkers
- The effects of osteopathic manipulative treatment on pain and disability in patients with chronic low back pain: a single-blinded randomized controlled trial
- The relationship of depressive symptoms with pain and analgesic use in Turkish adolescents
- IL-33/ST2 signaling in the pathogenesis of chronic pain and itch
- Subgroups of pelvic pain are differentially associated with endometriosis and inflammatory comorbidities: a latent class analysis
- Optimal Frequency in rTMS for the Management of Chronic Pain: A Network Meta-Analysis of Randomized Controlled Trials
- Prevalence of chronic and multisite pain in adolescents and young adults with ADHD: a comparative study between clinical and general population samples (the HUNT study)
- Evidence- and data-driven classification of low back pain via artificial intelligence: Protocol of the PREDICT-LBP study
- Antimicrobial therapies for chronic pain (part 2): the prevention and treatment of chronic pain
- Chronic pain in pediatric patients: epidemiology, pathophysiology, and mitigation strategies
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder
- Impact of high deductible health plans on U.S. adults with chronic pain
- Bidirectional Mendelian Randomization study of personality traits reveals a positive feedback loop between neuroticism and back pain
- Clinical and radiomics feature-based outcome analysis in lumbar disc herniation surgery
- Unsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care
- Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis
- Effectiveness of Acceptance and Commitment Therapy (ACT) for the Management of Postsurgical Pain: Study Protocol of a Randomized Controlled Trial (SPINE-ACT Study)