Evidence
Sci Rep. 2024 Feb 9;14(1):3313. doi: 10.1038/s41598-024-53728-3.
ABSTRACT
We aimed to examine the association between opioid use and the development of dementia in patients with chronic non-cancer pain in South Korea. Data were extracted from the National Health Insurance Service database in South Korea. Adult patients diagnosed with musculoskeletal diseases with chronic non-cancer pain between 2010 and 2015 were included in the analysis. Patients who were prescribed opioids regularly and continuously for ≥ 90 days were classified as opioid users. In total, 1,261,682 patients with chronic non-cancer pain were included in the final analysis, of whom 21,800 (1.7%) were opioid users. From January 1, 2016 to December 31, 2020, 35,239 (2.8%) patients with chronic non-cancer pain were newly diagnosed with dementia. In the multivariable model, opioid users showed a 15% higher risk of developing dementia than the control group. Additionally, opioid users showed a 15% and 16% higher risk of developing Alzheimer’s disease and unspecified dementia, respectively, than the control group, but did not show any significant differences for vascular dementia. Among adult patients with chronic non-cancer pain, opioid users were at a higher risk of developing dementia than the control group; the risk was significantly higher for Alzheimer’s disease but not for vascular dementia in this study. Our results suggest that in patients with CNCP, public health strategies should target opioid users for early dementia detection and intervention.
PMID:38331973 | DOI:10.1038/s41598-024-53728-3
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
🌐 90 Days
VR Related Evidence Matrix
- Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
- Psykiske lidelser og plager ved vedvarende opioidbruk for langvarige ikke-kreftrelaterte smerter – en registerstudie
- Psykiske lidelser og plager ved vedvarende opioidbruk for langvarige ikke-kreftrelaterte smerter – en registerstudie
- Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- Intersectional Risk and the Significant Gap in Care for Persons with Co-occurring Chronic Pain and Opioid Withdrawal
- Impact of the Narcotics Information Management System on Opioid Use Among Outpatients With Musculoskeletal and Connective Tissue Disorders: Quasi-Experimental Study Using Interrupted Time Series
- Risk of Unfavorable Trajectories of Chronic Pain Severity - Results of a Longitudinal Study in School Children
- Pharmacodynamic effects following co-administration of cannabinoids and opioids: A scoping review of human experimental studies
- Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database
- Stepped Care for Patients to Optimize Whole Recovery (SC-POWR): An Effectiveness Trial Evaluating a Stepped Care Model for Individuals With Opioid Use Disorder and Chronic Pain
- Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives
- The association of pain impact and sleep disruption with opioid withdrawal during opioid-use disorder treatment
- Racial and Ethnic Disparities in the Prescribing of Pain Medication in US Primary Care Settings, 1999-2019: Where Are We Now?
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain
- Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors
- Association of state-level prescription drug monitoring program implementation with opioid prescribing transitions in primary care in Australia
- Assessing men with opioid use disorder for testosterone deficiency after the development of symptoms
- Self-reported pain severity and use of cannabis and opioids in persons with HIV in an urban primary care setting in Northern California: A cross-sectional study
- Multimodal Acute Pain Management in the Parturient with Opioid Use Disorder: A Review
- Patient perspectives on mental health and pain management support needed versus received during opioid deprescribing
- Exploring Palliative Care Needs Among Patients With Cancer and Non-Cancer Serious Chronic Diseases: A Comparison Study
- Impact of the COVID-19 pandemic on mortality and loss to follow-up among patients with dementia receiving anti-dementia medications
- Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention
- Association of chronic pain with suicide attempt and death by suicide: a two-sample Mendelian randomization
- Characterizing Acute and Postsurgical Pain Management in Patients Receiving Buprenorphine or Buprenorphine/naloxone
- Opioid-free anesthesia : Wrong track or meaningful exit from the era of opioid-based analgesia?
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder
- Sub-anesthetic dose of esketamine decreases postoperative opioid self-administration after spine surgery: a retrospective cohort analysis
- Overcoming patient pain together: Breast cancer patients and caregivers' pre-treatment psychosocial distress linked to patients' pain interference during the first year of treatment
- Patient and pharmacist perspectives on opioid misuse screening and brief interventions in community pharmacies
- Opioids and Youth Athletes
- Mechanisms of pain in aging and age-related conditions: focus on caregivers
- Neuropsychiatric Effects Associated with Opioid-Based Management for Palliative Care Patients
- Chronic pain in pediatric patients: epidemiology, pathophysiology, and mitigation strategies
- Take-Home Naloxone Access and Use among Older Adults Living with Pain: A Scoping Review
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
- Peer victimization, posttraumatic stress symptoms, and chronic pain: A longitudinal examination
- The mediating role of posttraumatic stress disorder symptoms in pain cognitions among Veterans with chronic pain
- Long-term opioid therapy dose patterns in United States patients
- Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment
- Declining but Pronounced State-Level Disparities in Prescription Opioid Distribution in the United States
- Anxiety, pain catastrophizing, and pain outcomes among older adults with chronic orofacial pain
- Pain management for post-treatment survivors of complex cancers: a qualitative study of opioids and cannabis
- Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease
- Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease
- Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation
- Medication-based Comorbidity Measures and Prostate Cancer Treatment Selection
- Medication-based Comorbidity Measures and Prostate Cancer Treatment Selection
- Opioid-Free Analgesia is Safe and Effective in Anterior Cervical Spine Surgery: A Randomized Controlled Trial
- Mental Health Service Contact Following Cancer Diagnosis and Associations with Cancer Mortality: Results from a Linked Population-Based Study of Adolescents and Young Adults in New South Wales
- Two-year Opioid Prescription Trends in Local Sanitary Agency Naples 3 South, Campania Region, Italy. Descriptive Analyses and AI-based Translational Perspectives
- Relationship between Pain and Dementia: The Mediating Effect of Depression among Chinese Elderly
- Medication-based treatment among rural, primary care patients diagnosed with opioid use disorder and alcohol use disorder
- Does the presence of chronic pain affect scores on cognitive screening tests/brief cognitive measures for dementia? A systematic review and meta-analysis
- Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
- Pain and Post-traumatic Stress Disorder Symptoms: Dyadic Relationships Between Canadian Armed Forces Members/Veterans with Chronic Pain and their Offspring
- Blood pressure response to extended-release naltrexone in heroin and prescription opioid users and its implications for cardiovascular morbidity
- A Pathophysiological Approach for Selecting Medications to Treat Nociceptive and Neuropathic Pain in Servicemembers
- A Pathophysiological Approach for Selecting Medications to Treat Nociceptive and Neuropathic Pain in Servicemembers
- Interdisciplinary pain rehabilitation for patients with Ehlers-Danlos syndrome and hypermobility spectrum disorders
- Methadone Withdrawal-Induced Psychosis: A Case Report
- A Single-Session, 2-Hour Version of Mindfulness-Oriented Recovery Enhancement (One MORE) Improves Chronic Pain Patients' Pain-Related Outcomes Through 3-Month Follow-Up in a Randomized Controlled Trial
Evidence Blueprint
Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
🌐 365 Days
VR Related Evidence Matrix
- Impact of prescribed opioid use on development of dementia among patients with chronic non-cancer pain
- Alcohol consumption and opioid craving among chronic pain patients prescribed long-term opioid therapy
- Opioid-related policy changes: Experiences and perspectives from people who use opioids to manage non-cancer chronic pain
- Barriers to Adequate Pain Control and Opioid Use Among Cancer Survivors: Implications for Nursing Practice
- Feasibility and Acceptability of an Overdose Prevention Intervention Delivered by Community Pharmacists for Patients Prescribed Opioids for Chronic Non-Cancer Pain
- Psykiske lidelser og plager ved vedvarende opioidbruk for langvarige ikke-kreftrelaterte smerter – en registerstudie
- Psykiske lidelser og plager ved vedvarende opioidbruk for langvarige ikke-kreftrelaterte smerter – en registerstudie
- Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder
- Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations
- Framing Chronic Pain in U.S. News Coverage of the Opioid Epidemic (2012-2022)
- Patient-Provider Shared Decision-Making, Trust, and Opioid Misuse Among US Veterans Prescribed Long-Term Opioid Therapy for Chronic Pain
- Identifying Patterns of Pain, Depression, Anxiety, Interpersonal Trauma Exposure, and Nonmedical Prescription Opioid Use: Latent Class Analysis among Patients with Chronic Pain
- Framing Cancer Survivors' Access to and Use and Disposal of Prescribed Opioids Within the Opioid Epidemic
- Impact of high deductible health plans on U.S. adults with chronic pain
- Impact of renal and hepatic function on first opioid prescriptions in cancer patients: an acute care hospital database study linked to medical claims data and laboratory data
- Risks of opioid overdose among New York State Medicaid recipients with chronic pain before and during the COVID-19 pandemic
- The effect of a music-based caregiving intervention on pain intensity in nursing home patients with dementia. A cluster-randomized controlled study
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study
- The common neurological basis and targeted therapeutic approaches for chronic pain and opioid addiction
- STRategies to Improve Pain and Enjoy life (STRIPE): results of a pragmatic randomized trial of pain coping skills training and opioid medication taper guidance for patients on long-term opioid therapy
- Reducing opioid use for chronic non-cancer pain in primary care using an evidence-based, theory-informed, multistrategic, multistakeholder approach: a single-arm time series with segmented regression
- The Analgesic Mismanagement of a Patient With Ehlers-Danlos Syndrome (Hypermobility Variant): A Case Report
- Prevalence and correlates of high-dose opioid use among survivors of head and neck cancer
- Intersectional Risk and the Significant Gap in Care for Persons with Co-occurring Chronic Pain and Opioid Withdrawal
- Impact of the Narcotics Information Management System on Opioid Use Among Outpatients With Musculoskeletal and Connective Tissue Disorders: Quasi-Experimental Study Using Interrupted Time Series
- Are opioids effective analgesics and is physiological opioid dependence benign?: Revising current assumptions to effectively manage long-term opioid therapy and its deprescribing
- Socioeconomic risk factors for long-term opioid use: A national registry-linkage study
- Counseling for opioids prescribed at discharge of hospitalized adolescent trauma patients
- Medical Marijuana for Pain Management in Hospice Care as a Complementary Approach to Scheduled Opioids: A Single Arm Study
- Risk of Unfavorable Trajectories of Chronic Pain Severity - Results of a Longitudinal Study in School Children
- An Appraisal of Using Opioids in Patients with Opioid Use Disorder
- Pharmacodynamic effects following co-administration of cannabinoids and opioids: A scoping review of human experimental studies
- Pain Management in Patients With Opioid Use Disorder on Extended-release Buprenorphine: A Case Report
- Pain Management in Older Adults before and during the First Year of Covid-19 Pandemic: Prevalence, Trends, and Correlates
- Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer
- Risk Factors for Self-Harm Ideation Among Persons Treated With Opioids for Chronic Low Back Pain
- Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database
- Identifying patients with opioid use disorder using International Classification of Diseases (ICD) codes: Challenges and opportunities
- Risk factors for chronic prescription opioid use in Multiple Sclerosis
- TRPA1 rare variants in chronic neuropathic and nociplastic pain patients
- Unsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care
- Stepped Care for Patients to Optimize Whole Recovery (SC-POWR): An Effectiveness Trial Evaluating a Stepped Care Model for Individuals With Opioid Use Disorder and Chronic Pain
- Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury
- Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives
- Comprehensive Approach to Opioid Management in a Primary Care Network
- Addressing the Opioid Crisis-The Need for a Pain Management Intervention in Community Pharmacies in Canada: A Narrative Review
- The association of pain impact and sleep disruption with opioid withdrawal during opioid-use disorder treatment
- Racial and Ethnic Disparities in the Prescribing of Pain Medication in US Primary Care Settings, 1999-2019: Where Are We Now?
- Psychological profiles and prescription opioid misuse, craving, and withdrawal in people with chronic pain
- Assessing Relapse in Patients with Opioid-Use Disorder and Chronic Non-Cancer Pain
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain
- The impact of rumination on fibromyalgia pain after physical activity: an experimental study
- Ethical considerations in the relief of cancer pain
- Identification of opioid use disorder using electronic health records: Beyond diagnostic codes
- Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors
- Association of state-level prescription drug monitoring program implementation with opioid prescribing transitions in primary care in Australia
- Assessing men with opioid use disorder for testosterone deficiency after the development of symptoms
- Self-reported pain severity and use of cannabis and opioids in persons with HIV in an urban primary care setting in Northern California: A cross-sectional study
- Opioid prescriptions among Sami and non-Sami with chronic pain: The SAMINOR 2 Questionnaire Survey and the Norwegian Prescription Database
- Multimodal Acute Pain Management in the Parturient with Opioid Use Disorder: A Review
- Green Light-Based Analgesia - Novel Nonpharmacological Approach to Fibromyalgia Pain: A Pilot Study
- Optimizing the use of ketamine to reduce chronic postsurgical pain in women undergoing mastectomy for oncologic indication: study protocol for the KALPAS multicenter randomized controlled trial
- Cebranopadol for the Treatment of Chronic Pain