Evidence
Int J Neuropsychopharmacol. 2023 Jun 20:pyad030. doi: 10.1093/ijnp/pyad030. Online ahead of print.
ABSTRACT
The transcription factor p53, a widely accepted tumor suppressor, regulates the expression of many oncogenes and their downstream signaling pathways, resulting in a series of biological outcomes. Mutations and deletions of the p53 gene often occur in tumor tissues and are involved in their development. In addition to its role in tumors, p53 has a widespread expression in the brain and participates in most cell processes, such as dendrite formation, oxidative stress, apoptosis, autophagy, DNA repair and cell cycle arrest. Therefore, abnormalities in p53 and its related signaling pathways play important roles in the diagnosis and treatment of central nervous system (CNS) diseases. This review mainly discusses the latest findings regarding the role of p53 in some CNS diseases, such as brain tumors, Alzheimer’s disease, Parkinson’s disease, autism, epilepsy, spinocerebellar ataxia and so on, to provide a comprehensive interpretation of the treatment of neurological diseases from a new perspective.
PMID:37338366 | DOI:10.1093/ijnp/pyad030
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