Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
G3 (Bethesda). 2024 Aug 17:jkae197. doi: 10.1093/g3journal/jkae197. Online ahead of print.
ABSTRACT
Caenorhabditis elegans (C. elegans) is one of the most popular model organisms used to genetically dissect complex biological phenomena. One common technique used routinely in the C. elegans laboratory is the generation of strains carrying combinations of genetic mutations via classical genetic crosses. Here, we have developed a simple and convenient application to quickly identify useful genetic markers (phenotypical and fluorescent) and their chromosomal positions to aid in the development of genetic cross strategies. The user-friendly software identifies and prioritises markers with the least genetic distance to a gene of interest, as well as displays the strain name, ease of scoring, nature of the marker (fluorescent transgene or phenotypic information), mating efficiency, and number of available alleles. In addition, recombination frequencies between the gene of interest and each genetic marker are calculated automatically. The application, called “SoMarker”, is designed for both MacOS and Windows environments and is available to freely download and modify through open-source software.
PMID:39152791 | DOI:10.1093/g3journal/jkae197
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
SoMarker: a genetic marker searching tool for C. elegans
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients Attitudes of autistic adults toward genetic testing for autism Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment Processing language partly shares neural genetic basis with processing tools and body parts Processing language partly shares neural genetic basis with processing tools and body parts Efficient Genetic Transformation and Suicide Plasmid-mediated Genome Editing System for Non-model Microorganism Erwinia persicina Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease The genetics of amyotrophic lateral sclerosis Genetic Diagnostic Yield in Autism Spectrum Disorder (ASD) and Epilepsy Phenotypes in Children with Genetically Defined ASD Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study Understanding individualised genetic interventions as research-treatment hybrids Generalized genetic liability to substance use disorders Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis Distinct genetic liability profiles define clinically relevant patient strata across common diseases Molecular genetics and diversity of choroid plexus tumors Molecular genetics and diversity of choroid plexus tumors Overlapping genetic influences between creativity and borderline personality symptoms in a large Dutch sample Modelling human genetic disorders in Xenopus tropicalis Genetic determinants of coping, resilience and self-esteem in schizophrenia suggest a primary role for social factors and hippocampal neurogenesis Genetics of suicide ideation. A role for inflammation and neuroplasticity? Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis The importance of genetic counselling for turner syndrome transition The impact of family-genetic risk scores on social functioning in individuals affected with six major psychiatric and substance use disorders in a Swedish National Sample Rapid, Efficient, and Universally Applicable Genetic Engineering of Intestinal Organoid with a Sequential Monolayer to Three-Dimensional Strategy Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models The genetic architecture of biological age in nine human organ systems The diagnostic yield of genetic and metabolic investigations in syndromic and nonsyndromic patients with autism spectrum disorder, global developmental delay, or intellectual disability from a dedicated neurodevelopmental disorders genetics clinic Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice Short Tandem Repeats in the era of next-generation sequencing: from historical loci to population databases Short Tandem Repeats in the era of next-generation sequencing: from historical loci to population databases Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review Vitamin B5 is a context-dependent dietary regulator of nociception Prospective Effects of Self-Rated Health on Dementia Risk in Two Twin Studies of Aging Modifying flavor profiles of Saccharomyces spp. for industrial brewing using FIND-IT, a non-GMO approach for metabolic engineering of yeast Modifying flavor profiles of Saccharomyces spp. for industrial brewing using FIND-IT, a non-GMO approach for metabolic engineering of yeast Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in a South African population The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship Advances in the Differentiation of hiPSCs into Cerebellar Neuronal Cells A Genomics-Driven Artificial Intelligence-Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia Barriers, motivators and strategies to increase participation in genetic research among Asian and Black families of autistic individuals Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity in Traits Across Polygenic Phenotypes An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure Family-based genome-wide association analysis of novelty seeking in a Korean schizophrenic population: A pilot study Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan A hybrid model for predicting response to risperidone after first episode of psychosis The impact of genetic factors on the response to migraine therapy
Evidence Blueprint
SoMarker: a genetic marker searching tool for C. elegans
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
SoMarker: a genetic marker searching tool for C. elegans
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals Ribonucleotide reductase inhibition improves the symptoms of a Caenorhabditis elegans model of Alzheimer's Disease TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy Genetic Interactions of Progranulin Across the ALS-FTD Spectrum and Beyond Comprehensive exploration of multi-modal and multi-branch imaging markers for autism diagnosis and interpretation: insights from an advanced deep learning model Updates to the Alliance of Genome Resources Central Infrastructure Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients Attitudes of autistic adults toward genetic testing for autism See Elegans: Simple-to-use, accurate, and automatic 3D detection of neural activity from densely packed neurons Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder GBA-associated Parkinson's disease in Hungary: clinical features and genetic insights Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages Exploring genetic testing requests, genetic alterations and clinical associations in a cohort of children with autism spectrum disorder Brain tumour genetic network signatures of survival Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology Recent insights from non-mammalian models of brain injuries: an emerging literature System-wide mapping of peptide-GPCR interactions in C. elegans Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment Processing language partly shares neural genetic basis with processing tools and body parts Processing language partly shares neural genetic basis with processing tools and body parts TWISP: A Transgenic Worm for Interrogating Signal Propagation in C. elegans Efficient Genetic Transformation and Suicide Plasmid-mediated Genome Editing System for Non-model Microorganism Erwinia persicina Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease More than nature and nurture, indirect genetic effects on children's academic achievement are consequences of dynastic social processes Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans Dissecting Parkinson's disease with long-read RNA-sequencing Toolkits for detailed and high-throughput interrogation of synapses in C. elegans Family-based genetic analysis in schizophrenia by whole-exome sequence to identify rare pathogenic variants The genetics of amyotrophic lateral sclerosis Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture Principles and methods for transferring polygenic risk scores across global populations Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency Genetic-based patient stratification in Alzheimer's disease A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders Functional Neural Networks for High-Dimensional Genetic Data Analysis Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes New technique identifies earliest cases of genetic disorders from ancient DNA Genetic Diagnostic Yield in Autism Spectrum Disorder (ASD) and Epilepsy Phenotypes in Children with Genetically Defined ASD Prioritization of oligogenic variant combinations in whole exomes Deregulation of the Glymphatic System in Alzheimer's Disease: Genetic and Non-Genetic Factors Chemosensory detection of polyamine metabolites guides C. elegans to nutritive microbes Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans Understanding individualised genetic interventions as research-treatment hybrids Generalized genetic liability to substance use disorders Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of C. elegans Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis Progress and Implications from Genetic Studies of Bipolar Disorder Attitudes of parents of children with ADHD towards genetic testing: Data from a Turkish sample “In and Out of Context: Deciphering the Genetic and Genomic Architecture of Type 2 Diabetes” UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis