Evidence
Prev Med Rep. 2023 Dec 7;37:102536. doi: 10.1016/j.pmedr.2023.102536. eCollection 2024 Jan.
ABSTRACT
PURPOSE: The aim of this study was to explore the relationship between non-alcoholic fatty liver disease (NAFLD) and the two blood inflammatory markers including the systemic immune-inflammation (SII) index, and the system inflammation response index (SIRI).
METHODS: The National Health and Nutrition Examination Survey data between the year of 2017-2018 was used for this cross-sectional study. In order to analyze the association of SII index, and SIRI and risk of NAFLD, we used multivariable logistic regression models, restricted cubic spline (RCS) plot, and subgroup analysis to analyze the data.
RESULTS: In total, there were 1,199 individuals who participated in the survey. As shown by the RCS plot, SII index, and SIRI were linked with NAFLD risk in a U-shaped pattern. With regard to known confounding variables, when comparing the lowest quartile, the odds ratio with 95 % confidence interval for prevalence of NAFLD across the quartiles of SII index and SIRI were (0.89 (0.57, 1.41), 0.56 (0.35, 0.89) and 1.01 (0.64, 1.59)), and (0.77 (0.48, 1.23), 0.79 (0.50, 1.24) and 0.94 (0.60, 1.47)), respectively. Additionally, SII index, and SIRI and NAFLD risk also were U-curve correlated among the participants in age ≥60 years, female, without hypertension, and BMI of ≥30 kg/m2.
CONCLUSIONS: There was a U-shaped association of SII index and SIRI with prevalence of NAFLD, indicating that SII index and SIRI should be monitored dynamically.
PMID:38186662 | PMC:PMC10767190 | DOI:10.1016/j.pmedr.2023.102536
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
The association of systemic inflammatory biomarkers with non-alcoholic fatty liver disease: a large population-based cross-sectional study
🌐 90 Days
VR Related Evidence Matrix
- Systemic immune-inflammatory biomarkers (SII, NLR, PLR and LMR) linked to non-alcoholic fatty liver disease risk
- Prognostic nutritional index (PNI) and risk of non-alcoholic fatty liver disease and advanced liver fibrosis in US adults: Evidence from NHANES 2017-2020
- Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study
- Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
- Screening the General Population for Non-Alcoholic Fatty Liver Disease: Model Development and Validation
- Dietary inflammatory impact on NAFLD development in obese vs. lean individuals: an analysis based on NHANES 2003-2018
- Chronic exposure to ambient air pollution and the risk of non-alcoholic fatty liver disease: A cross-sectional study in Taiwan and Hong Kong
- Systemic inflammatory response index and monocyte-to-high density lipoprotein ratio- new biomarkers remarking the inflammation in primary sarcopenia: The SIMPS study
- Association between weight-adjusted waist index and non-alcoholic fatty liver disease: a population-based study
- Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea
- Increased Risk of Colorectal Adenomas with Metabolic-Associated Fatty Liver Disease Components
- Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers
- Exploring the interplay of gut microbiota, inflammation, and LDL-cholesterol: a multiomics Mendelian randomization analysis of their causal relationship in acute pancreatitis and non-alcoholic fatty liver disease
- Systemic inflammation in Ab1-40-induced Alzheimer's disease model: New translational opportunities
- The association between diverse serum folate with MAFLD and liver fibrosis based on NHANES 2017-2020
- Visceral and subcutaneous abdominal fat is associated with non-alcoholic fatty liver disease while augmenting Metabolic Syndrome's effect on non-alcoholic fatty liver disease: A cross-sectional study of NHANES 2017-2018
- Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus
- Determinants of non-alcoholic fatty liver disease in young people: Maternal, neonatal, and adolescent factors
- Dairy products intake and prevalence, incidence, and recovery of non-alcoholic fatty liver disease in Chinese population
- Awareness of Non-alcoholic Fatty Liver Disease and Its Determinants in Jazan, Saudi Arabia: A Cross-Sectional Study
- Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients
- The association between healthy eating index-2015 with anthropometric, cardiometabolic and hepatic indices among patients with non-alcoholic fatty liver disease
- Associations of arsenic exposure and arsenic metabolism with the risk of non-alcoholic fatty liver disease
- Association Between Liver Fibrosis Score and Diabetic Kidney Disease: A Retrospective Cross-Sectional Study of Hospitalized Patients
- The diagnostic utility of FIB-4 as a non-invasive tool for liver fibrosis scoring among NAFLD patients: a retrospective cross-sectional study
- Analysis of non-alcoholic fatty liver disease differences from metabolic dysfunction-associated fatty liver disease based on clinical features
- Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease
- Effects of low fat diet on inflammatory parameters in individuals with obesity/overweight and non-alcoholic fatty liver disease: A cross-sectional study
- Association between Baltic sea diet and healthy Nordic diet index with risk of non-alcoholic fatty liver disease: a case-control study
- Spleen volume is independently associated with non-alcoholic fatty liver disease, liver volume and liver fibrosis
- Erythropoietin hyporesponsiveness in non-alcoholic fatty liver disease
- Serum Vitamin D Level in Overweight Individuals and Its Correlation With the Incidence of Non-alcoholic Fatty Liver Disease
- Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
- Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)
- Association of the habitual dietary intake with the fatty liver index and effect modification by metabotypes in the population-based KORA-Fit study
- Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease
- Establishment of a machine learning predictive model for non-alcoholic fatty liver disease: A longitudinal cohort study
- Predictors for liver fibrosis in non-alcoholic patients with psoriatic diseases: A multicenter cross sectional-study
- Predictors for liver fibrosis in non-alcoholic patients with psoriatic diseases: A multicenter cross sectional-study
- Exposure to per- and polyfluoroalkyl substance and metabolic syndrome: A nationally representative cross-sectional study from NHANES, 2003-2018
- The role of endoplasmic reticulum stress-related genes in the diagnosis and subtyping of non-alcoholic fatty liver disease
- Non-alcoholic fatty liver modifies associations of body mass index and waist circumference with cardiometabolic risk: The CARDIA study
- The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study
- Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)
- The interplay between diabetes and non-alcoholic fatty liver disease: a cross-sectional study from Pakistan
- The interplay between diabetes and non-alcoholic fatty liver disease: a cross-sectional study from Pakistan
- The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease
- Self-management behaviours in adults with non-alcoholic fatty liver disease: a cross-sectional survey from China
- Association between sleep duration and a new onset of nonalcoholic fatty liver disease
- From NAFLD to NASH: Understanding the spectrum of non-alcoholic liver diseases and their consequences
- The Influence of Emodin Succinyl Ethyl Ester on Non-Alcoholic Steatohepatitis Induced by a Diet High in Fructose, Cholesterol, and Fat in Mice
- Unveiling the mitophagy puzzle in non-alcoholic fatty liver disease (NAFLD): Six hub genes for early diagnosis and immune modulatory roles
- Correlation of Grades of Non-alcoholic Fatty Liver on Ultrasound With Blood Parameters
- CCN3/NOV Serum Levels in Non-Alcoholic Fatty Liver Disease (NAFLD) Patients in Comparison with the Healthy Group and their Correlation with TNF-alpha and IL-6
- Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study
- Immunomodulation in non-alcoholic fatty liver disease: exploring mechanisms and applications
- Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017-2020
- Comparison of size of the liver between patients with non-alcoholic fatty liver disease and healthy controls
- Association between biological aging and the risk of mortality in individuals with non-alcoholic fatty liver disease: A prospective cohort study
- LASSO-derived model for the prediction of lean-non-alcoholic fatty liver disease in examinees attending a routine health check-up
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
- Comorbidity and multimorbidity in patients with cirrhosis, hospitalised in an internal medicine ward: a monocentric, cross-sectional study
- A Validation Study of Non-invasive Scoring Systems for Assessing Severity of Hepatic Fibrosis in a Cohort of South Indian Patients With Non-alcoholic Fatty Liver Disease
- Targeting Non-Alcoholic Fatty Liver Disease with Hawthorn Ethanol Extract (HEE): A Comprehensive Examination of Hepatic Lipid Reduction and Gut Microbiota Modulation
Evidence Blueprint
The association of systemic inflammatory biomarkers with non-alcoholic fatty liver disease: a large population-based cross-sectional study
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
The association of systemic inflammatory biomarkers with non-alcoholic fatty liver disease: a large population-based cross-sectional study
🌐 365 Days
VR Related Evidence Matrix
- Association of Systemic Immune-Inflammation Index with Non-Alcoholic Fatty Liver Disease: A Population-Based Cross-Sectional Study
- Systemic immune-inflammatory biomarkers (SII, NLR, PLR and LMR) linked to non-alcoholic fatty liver disease risk
- A combined analysis of TyG index, SII index, and SIRI index: positive association with CHD risk and coronary atherosclerosis severity in patients with NAFLD
- Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study
- Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study
- Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study
- Prognostic nutritional index (PNI) and risk of non-alcoholic fatty liver disease and advanced liver fibrosis in US adults: Evidence from NHANES 2017-2020
- Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population
- Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study
- Association between dietary vitamin A intake from different sources and non-alcoholic fatty liver disease among adults
- Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study
- Role of BMI in the relationship between dietary inflammatory index and non-alcoholic fatty liver disease: an intermediary analysis
- Association of weight-adjusted-waist index with non-alcoholic fatty liver disease and liver fibrosis: a cross-sectional study based on NHANES
- Association between the Triglyceride-Glucose Index and Non-Alcoholic Fatty Liver Disease in patients with Atrial Fibrillation
- The relationship between alcohol consumption and chronic kidney disease in patients with nonalcoholic fatty liver disease
- Triglyceride-Glucose Index is Significantly Associated with the Risk of Hyperuricemia in Patients with Nonalcoholic Fatty Liver Disease
- Overall and subgroup prevalence of non-alcoholic fatty liver disease and prevalence of advanced fibrosis in the United States: an updated national estimate in National Health and Nutrition Examination Survey (NHANES) 2011-2018
- Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults
- Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population
- Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies
- Correlation of Nonalcoholic Fatty Liver Disease with Dietary Folate and Serum Folate in U.S. Adults: Cross-Sectional Analyses from National Health and Nutrition Examination Survey 2009-2018
- Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults
- Relationship between blood-based inflammatory indices and clinical score of schizophrenia patients: A cross-sectional study
- Association of dietary inflammatory potential and non-alcoholic fatty liver disease in US adults
- The Metabolic Score for Insulin Resistance Index is Superior to the Triglyceride and Glucose Index in Identifying Nonalcoholic Fatty Liver Disease in Hyperuricemia Subjects
- Association between body roundness index and risk of ultrasound-defined non-alcoholic fatty liver disease
- Crohn´s disease is an independent risk factor for liver fibrosis in patients with inflammatory bowel disease and non-alcoholic fatty liver disease
- The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
- Fatty Liver Index and Its Association with 10-Year Atherosclerotic Cardiovascular Disease Risk: Insights from a Population-Based Cross-Sectional Study in China
- Association of Dietary Acid Load with Nonalcoholic Fatty Liver Disease and Advanced Liver Fibrosis in US Adults: Evidence from NHANES 1999-2018
- Relationship Between Six Insulin Resistance Surrogates and Nonalcoholic Fatty Liver Disease Among Older Adults: A Cross-Sectional Study
- Ultrasonographic findings of metabolic dysfunction-associated fatty liver disease: A comparative study with non-alcoholic fatty liver disease and clinical characteristics
- Immunology of gut microbiome and liver in non-alcoholic fatty liver disease (NAFLD): mechanisms, bacteria, and novel therapeutic targets
- Thiol-disulphide homeostasis, ischemia-modified albumin, complete blood count-derived inflammatory markers and C-reactive protein from acute mania to early remission in bipolar disorder
- Dietary inflammatory index (DII) is correlated with the incidence of non-alcoholic fatty liver disease (NAFLD): Fasa PERSIAN cohort study
- Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
- Screening the General Population for Non-Alcoholic Fatty Liver Disease: Model Development and Validation
- Dietary choline intake and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2017-2018
- Relationships between education and non-alcoholic fatty liver disease
- Association between micronutrients intake and metabolic-associated fatty liver disease: a cross-sectional study based on the National Health and Nutrition Examination Survey
- Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses
- Prevalence of Subclinical Cardiovascular Disease in Patients with Non-Alcoholic-Fatty Liver Disease: Analysis of the Paracelsus 10.000 Cohort Study
- Non-alcoholic fatty liver disease is associated with hyperandrogenism in women with polycystic ovary syndrome
- Association between klotho and non-alcoholic fatty liver disease and liver fibrosis based on the NHANES 2007-2016
- Risk factors for macro vascular disease in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease
- The association of the healthy food diversity index with the risk of non-alcoholic fatty liver disease among the adult population
- The Association between Liver Enzymes and Mortality Stratified by Non-Alcoholic Fatty Liver Disease: An Analysis of NHANES III
- Impact of Porphyromonas gingivalis-odontogenic infection on the pathogenesis of non-alcoholic fatty liver disease
- Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
- Dietary inflammatory impact on NAFLD development in obese vs. lean individuals: an analysis based on NHANES 2003-2018
- A survey on the awareness, current management, and barriers for non-alcoholic fatty liver disease among the general Korean population
- Chronic exposure to ambient air pollution and the risk of non-alcoholic fatty liver disease: A cross-sectional study in Taiwan and Hong Kong
- Association of sex-specific body mass index and waist circumference trajectories with non-alcoholic fatty liver disease incidence based on growth mixture modeling
- Survey of Dietary Habits and Physical Activity in Japanese Patients with Non-Obese Non-Alcoholic Fatty Liver Disease
- Triglycerides Mediate the Influence of Body Mass Index on Non-Alcoholic Fatty Liver Disease in a Non-Obese Chinese Population with Normal Low-Density Lipoprotein Cholesterol Levels
- Systemic inflammatory response index and monocyte-to-high density lipoprotein ratio- new biomarkers remarking the inflammation in primary sarcopenia: The SIMPS study
- Association between metabolism-related chronic disease combination and prevalence of non-alcoholic fatty liver disease in community residents in Shanghai
- Association between weight-adjusted waist index and non-alcoholic fatty liver disease: a population-based study
- Single-chemical and mixture effects of multiple volatile organic compounds exposure on liver injury and risk of non-alcoholic fatty liver disease in a representative general adult population
- Association of volatile methylsiloxanes exposure with non-alcoholic fatty liver disease among Chinese adults
- Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea
- P045 Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with inflammatory bowel disease (IBD) in a Brazilian public healthcare clinic
- Cardiac remodelling in non-alcoholic fatty liver disease in the general population
- Validation of the Fatty Liver Index for identifying non-alcoholic fatty liver disease in a Kenyan population