Evidence
J Psychiatr Res. 2023 Jun 5;164:72-79. doi: 10.1016/j.jpsychires.2023.05.084. Online ahead of print.
ABSTRACT
OBJECTIVE: Pediatric bipolar disorder (PBD) is a psychiatric disorder marked by alteration of brain networks. However, the understanding of these alterations in topological organization still unclear. This study aims to leverage the functional connectome gradient to examine changes in functional network hierarchy in PBD.
METHOD: Connectome gradients were used to scrutinize the differences between functional gradient map in PBD patients (n = 68, aged 11 to 18) and healthy controls (HC, n = 37, aged 11 to 18). The association between regional altered gradient scores and clinical factors was examined. We further used Neurosynth to determine the correlation of the cognitive terms with the PBD principal gradient changes.
RESULTS: Global topographic alterations were exhibited in the connectome gradient in PBD patients, involving gradient variance, explanation ratio, gradient range, and gradient dispersion in the principal gradient. Regionally, PBD patients revealed that the default mode network (DMN) held the most majority of the brain areas with higher gradient scores, whereas a higher proportion of brain regions with lower gradient scores in the sensorimotor network (SMN). These regional gradient differences exhibited significant correlation with clinical features and meta-analysis terms including cognitive behavior and sensory processing.
CONCLUSION: Functional connectome gradient presents a thorough investigation of large-scale networks hierarchy in PBD patients. This exhibited excessive segregation between DMN and SMN supports the theory of imbalance in top-down control and bottom-up in PBD and provides a possible biomarker for diagnostic assessment.
PMID:37331260 | DOI:10.1016/j.jpsychires.2023.05.084
Estimated reading time: 5 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
The disruption of functional connectome gradient revealing networks imbalance in pediatric bipolar disorder
🌐 90 Days
Evidence Blueprint
The disruption of functional connectome gradient revealing networks imbalance in pediatric bipolar disorder
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence