The role of Sirtuin 2 in liver – An extensive and complex biological process
Evidence
Life Sci. 2024 Jan 17:122431. doi: 10.1016/j.lfs.2024.122431. Online ahead of print.
ABSTRACT
Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, and is expressed in multiple organs including liver, which plays important and complex roles by interacting with various substrates. Physiologically, Sirt2 can improve metabolic homeostasis. Pathologically, Sirt2 can alleviate inflammation, endoplasmic reticulum (ER) stress, promote liver regeneration, maintain iron homeostasis, aggravate fibrogenesis and regulate oxidative stress in liver. In liver diseases, Sirt2 can mitigate fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), but aggravate hepatitis B (HBV) and liver ischemia-reperfusion injury (LIRI). The role of Sirt2 in liver cancer and aging-related liver diseases, however, has not been fully elucidated. In this review, these biological processes regulated by Sirt2 in liver are summarized, which aims to update the function of Sirt2 in liver and to explore the potential role of Sirt2 as a therapeutic target for liver diseases.
Adv Gerontol. 2024;37(1-2):102-110.ABSTRACTAfter cholecystectomy, elderly patients require special attention, due to the influence of involution processes in the body on the formation of complications. To...
G Ital Nefrol. 2024 Jun 28;41(3):2024-vol3.ABSTRACTIgA nephropathy (IgAN) is a fairly common association with alcoholic liver disease. However, IgA vasculitis (IgAV) is quite an uncommon...
G Ital Nefrol. 2024 Jun 28;41(3):2024-vol3.ABSTRACTIgA nephropathy (IgAN) is a fairly common association with alcoholic liver disease. However, IgA vasculitis (IgAV) is quite an uncommon...
Eur J Clin Invest. 2024 Jun 28:e14276. doi: 10.1111/eci.14276. Online ahead of print.ABSTRACTBACKGROUND: Numerous recent studies have explored the association between metabolic dysfunction-associated steatotic liver...
Sci Adv. 2024 Jun 28;10(26):eadm6951. doi: 10.1126/sciadv.adm6951. Epub 2024 Jun 28.ABSTRACTFunctional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions in alcohol...
Medicine (Baltimore). 2024 Jun 28;103(26):e38241. doi: 10.1097/MD.0000000000038241.ABSTRACTWe hypothesized that the triglyceride-glucose (TyG)-alanine aminotransferase (ALT) index, which combines the TyG index with ALT, may enhance sensitivity...
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.