Evidence
iScience. 2023 Mar 22;26(4):106488. doi: 10.1016/j.isci.2023.106488. eCollection 2023 Apr 21.
ABSTRACT
Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here, specific gains and losses of astrocytic cell functions in the medial prefrontal cortex (mPFC) bidirectionally regulate depression-like symptoms. Remarkably, recombinant human Thrombospondin-1 (rhTSP1), an astrocyte-secreted protein, exerted rapidly antidepressant-like actions through tyrosine hydroxylase (Th)/dopamine (DA)/dopamine D2 receptors (D2Rs) pathways, but not dopamine D1 receptors (D1Rs), which was dependent on SH3 and multiple ankyrin repeat domains 3 (Shank3) in the mPFC. TSP1 in the mPFC might have potential as a target for treating clinical depression.
PMID:37091229 | PMC:PMC10119609 | DOI:10.1016/j.isci.2023.106488
Add to Google Keep
Estimated reading time: 2 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors
🌐 90 Days
VR Related Evidence Matrix
- Manipulation of alpha4betadelta GABA(A) receptors alters synaptic pruning in layer 3 prelimbic prefrontal cortex and impairs temporal order recognition: Implications for schizophrenia and autism
- Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
- Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex
- The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD
- Effects of Interleukin-19 Overexpression in the Medial Prefrontal Cortex on Anxiety-Related Behaviors, BDNF Expression and p38/JNK/ERK Pathways
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
- Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese
- Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
- Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection
- Extrasynaptic localization is essential for α5GABAA receptor modulation of dopamine system function
- Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
- Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- Affective disorders and the loudness dependence of the auditory evoked potential: Serotonin and beyond
- Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications
- Shank3 deficiency elicits autistic-like behaviors by activating p38alpha in hypothalamic AgRP neurons
- Protective effects of dopamine against non-alcoholic steatohepatitis via inhibiting p65 pathways in vivo and in vitro
- Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression
- Atypical antipsychotics in the treatment of depression in affective disorders and schizophrenia (using the aripiprazole model)
- Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange
- Genetic background determines synaptic phenotypes in Arid1b-mutant mice
- Functions and mechanisms of adenosine and its receptors in sleep regulation
- Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice
- Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies
- SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD
- Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
- Assessing the influence of dopamine and mindfulness on the formation of routines in visual search
- Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
- Parvalbumin interneuron deficiency in the prefrontal and motor cortices of spontaneously hypertensive rats: an attention-deficit hyperactivity disorder animal model insight
- NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses
- NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses
- Neurophysiological evidence that frontoparietal connectivity and GABA-A receptor changes underpin the antidepressant response to ketamine
- Astrocyte switch to the hyperactive mode
- Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges
- [18F]Fluspidine-A PET Tracer for Imaging of σ1 Receptors in the Central Nervous System
- Suicide attempt in a dopamine agonist withdrawal syndrome in Parkinson's disease
- The role of the brain renin-angiotensin system in Parkinsons disease
- Reserpine-induced rat model for depression: Behavioral, physiological and PET-based dopamine receptor availability validation
- Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
- Molecular signatures of attention networks
- The role of serotonin in depression-A historical roundup and future directions
- Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus
- Functions and pharmacology of α2β2 nicotinic acetylcholine receptors; in and out of the shadow of α4β2 nicotinic acetylcholine receptors
- Region-specific and age-related differences in astrocytes in the human brain
- Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance
- Selective targeting of mu opioid receptors to primary cilia
- Selective targeting of mu opioid receptors to primary cilia
- Effect of dopamine on limbic network connectivity at rest in Parkinson's disease patients with freezing of gait
- The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows
- Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons
- Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism
- Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism
- A potential neuromodulation target for PTSD in Veterans derived from focal brain lesions
- Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson's disease
- The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
- Dysregulated cholinergic signaling inhibits oligodendrocyte maturation following demyelination
- Dorsal motor vagal neurons can elicit bradycardia and reduce anxiety-like behavior
- Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system
Evidence Blueprint
Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors
🌐 365 Days
VR Related Evidence Matrix
- Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor-Receptor Interactions
- Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia
- δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions
- Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice
- Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation
- Manipulation of alpha4betadelta GABA(A) receptors alters synaptic pruning in layer 3 prelimbic prefrontal cortex and impairs temporal order recognition: Implications for schizophrenia and autism
- Linking input- and cell-type-specific synaptic plasticity to the reinforcement of alcohol-seeking behavior
- Impaired monoamine neural system in the mPFC of SHRSP/Ezo as an animal model of attention-deficit/hyperactivity disorder
- Novel synergistic treatment for depression: involvement of GSK3β-regulated AMPA receptors in the prefrontal cortex of mice
- Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function
- Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
- Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model
- Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model
- Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex
- Differential effects of dopamine receptor agonists ropinirole and quinpirole on locomotor and anxiolytic behaviors in larval zebrafish (Danio rerio): A role for the GABAergic and glutamate system?
- Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
- The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle
- Prefrontal neuronal ensembles link prior knowledge with novel actions during flexible action selection
- Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
- Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
- Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches
- Agomelatine: A Potential Multitarget Compound for Neurodevelopmental Disorders
- The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD
- Brain connectivity changes to fast versus slow dopamine increases
- Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2
- Effects of Interleukin-19 Overexpression in the Medial Prefrontal Cortex on Anxiety-Related Behaviors, BDNF Expression and p38/JNK/ERK Pathways
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
- Immunohistochemical Expression of Ki-67, Dopamine D1 and Dopamine D2 Receptors in Meningiomas in a Tertiary Institution in Mexico
- Long-term sevoflurane exposure relieves stress-enhanced fear learning and anxiety in PTSD mice
- Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes
- Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese
- Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits
- Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex
- Behavioral state-dependent modulation of prefrontal cortex activity by respiration
- Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
- Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory
- Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory
- Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex
- Divergent reward cue representations in the prefrontal cortex drive reward motivation in adolescence and adulthood
- The medial prefrontal cortex during flexible decisions: Evidence for its role in distinct working memory processes
- Evaluating lumateperone for its use in treating depressive episodes associated with bipolar I or II disorder in adults
- Free will: An Example of the Dopaminergic System
- The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling
- Next generation antidepressants with novel mechanisms for treatment resistant depression
- Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance
- Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism
- Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping
- Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection
- Epileptic activity triggers rapid ROCK1-dependent astrocyte morphology changes
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia
- Sub-second Dopamine Signals during Risky Decision-Making in Patients with Impulse Control Disorder
- Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior
- Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop
- Extrasynaptic localization is essential for α5GABAA receptor modulation of dopamine system function
- Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior
- Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
- Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
- Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits
- Compressed primary-to-transmodal gradient is accompanied with subcortical alterations and linked to neurotransmitters and cellular signatures in major depressive disorder