J Neurosci. 2024 May 20:e0060242024. doi: 10.1523/JNEUROSCI.0060-24.2024. Online ahead of print.

ABSTRACT

While the exertion of mental effort improves performance on cognitive tasks, the neural mechanisms by which motivational factors impact cognition remain unknown. Here, we used fMRI to test how changes in cognitive effort, induced by changes in task difficulty, impacts neural representations of working memory. Participants (both sexes) were precued whether working memory difficulty would be hard or easy. We hypothesized that hard trials demanded more effort as a later decision required finer mnemonic precision. Behaviorally, pupil size was larger and response times were slower on hard compared to easy trials suggesting our manipulation of effort succeeded. Neurally, we observed robust persistent activity during delay periods in prefrontal cortex, especially during hard trials. Yet, details of the memoranda could not be decoded from patterns in prefrontal activity. In the patterns of activity in visual cortex, however, we found strong decoding of memorized targets, where accuracy was higher on hard trials. To potentially link these across-region effects, we hypothesized that effort, carried by persistent activity in prefrontal cortex, impacts the quality of working memory representations encoded in visual cortex. Indeed, we found that the amplitude of delay period activity in frontal cortex predicted decoded accuracy in visual cortex on a trial-wise basis. These results indicate that effort-related feedback signals sculpt population activity in visual cortex, improving mnemonic fidelity.Significance Statement A full understanding of the neural mechanisms underlying our cognitive abilities depends on understanding their interplay with factors such as cognitive effort. Here, we relied on the simple intuition that some tasks require more effort than others and success depends on how hard we try. We show how the exertion of cognitive effort – trying harder – improves the quality of working memory representations in visual cortex mediated by feedback from prefrontal cortex. Such a mechanism describes how the limited resources that support working memory are allocated and strategically controlled. These results have implications for psychiatric disorders, like schizophrenia, where motivational deficits may masquerade as cognitive dysfunction.

PMID:38769009 | DOI:10.1523/JNEUROSCI.0060-24.2024