Evidence
AIDS Res Hum Retroviruses. 2023 Dec 8. doi: 10.1089/AID.2023.0068. Online ahead of print.
ABSTRACT
We evaluated the prevalence and correlates of HIV viral non-suppression and HIV drug resistance (HIV-DR) in a cohort of people who inject drugs living with HIV (PWID-LH) and their sexual and injecting partners living with HIV in Kenya. HIV-DR testing was performed on participants with viral non-suppression. Of 859 PWID-LH and their partners, 623 (72.5%) were on antiretroviral therapy (ART) ≥4 months and 148/623 (23.8%) were not virally suppressed. Viral non-suppression was more common among younger participants and those on ART for a shorter duration. Among 122 (82.4%) successfully sequenced samples, 55 (45.1%) had detectable major HIV-DR mutations, mainly to non-nucleoside and nucleotide reverse transcriptase inhibitors (NNRTI, NRTI). High levels of HIV-DR among those with viral non-suppression suggests need for viral load monitoring, adherence counselling, and timely switching to alternate ART regimens in this key population.
PMID:38063008 | DOI:10.1089/AID.2023.0068
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