Epilepsia Open. 2023 May 29. doi: 10.1002/epi4.12766. Online ahead of print.

ABSTRACT

OBJECTIVE: Anxiety and depression are common comorbidities in people living with epilepsy. Emerging research suggests that these conditions may even predate epilepsy onset. This review aims to summarize the prevalence of clinically significant anxiety and depressive symptoms in people with first seizures and newly diagnosed epilepsy, as well as clinicodemographic factors associated with these symptoms.

METHODS: A scoping literature review was performed. OVID Medline and Embase were searched from 1 January 2000 through 1 May 2022. Articles of interest were selected based on predetermined inclusion and exclusion criteria.

RESULTS: From 1836 studies identified on screening, 16 met eligibility criteria and were included in the review. Clinically significant anxiety and depressive symptoms, as determined by validated cut-off scores for anxiety and depression screening instruments, were common in people with first seizures (range 13-28%) and newly diagnosed epilepsy (range 11-45%). They were associated with a range of clinicodemographic factors including past psychiatric history and trauma, personality traits, self-esteem and stigma profiles.

SIGNIFICANCE: There is substantial evidence that clinically significant anxiety and depressive symptoms are often present at the time and shortly following a first seizure or epilepsy diagnosis. Future research is needed to better understand the complex interactions between these common psychiatric comorbidities, new onset seizure disorders, and certain clinicodemographic characteristics. This knowledge may inform targeted and holistic treatment approaches.

PMID:37247255 | DOI:10.1002/epi4.12766