Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer’s disease

1 May 2023

Evidence

Front Mol Neurosci. 2023 Apr 13;16:971565. doi: 10.3389/fnmol.2023.971565. eCollection 2023.

ABSTRACT

OBJECTIVE: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neuropathology and cognitive decline and associated with age. The comprehensive deoxyribonucleic acid methylation (DNAm)-transcriptome profile association analysis conducted in this study aimed to establish whole-genome DNAm profiles and explore DNAm-related genes and their potential functions. More appropriate biomarkers were expected to be identified in terms of AD.

MATERIALS AND METHODS: Illumina 450KGSE59685 dataset AD (n = 54) and HC (n = 21) and ribonucleic-acid-sequencing data GSE118553 dataset AD patients (n = 21) and HCs (n = 13) were obtained from the gene expression omnibus database before a comprehensive DNAm-transcriptome profile association analysis, and we performed functional enrichment analysis by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses (KEGG). Three transgenic mice and three wild-type mice were used to validate the hub genes.

RESULTS: A total of 18,104 DNAm sites in healthy controls (n = 21) and AD patients (n = 54) were surveyed across three brain regions (superior temporal gyrus, entorhinal cortex, and dorsolateral prefrontal cortex). With the addition of the transcriptome analysis, eight hypomethylated-related highly expressed genes and 61 hypermethylated-related lowly expressed genes were identified. Based on 69 shared differentially methylated genes (DMGs), the function enrichment analysis indicated Guanosine triphosphate enzymes (GTPase) regulator activity, a synaptic vesicle cycle, and tight junction functioning. Following this, mice-based models of AD were constructed, and five hub DMGs were verified, which represented a powerful, disease-specific DNAm signature for AD.

CONCLUSION: The results revealed that the cross-brain region DNAm was altered in those with AD. The alterations in DNAm affected the target gene expression and participated in the key biological processes of AD. The study provides a valuable epigenetic resource for identifying DNAm-based diagnostic biomarkers, developing effective drugs, and studying AD pathogenesis.

PMID:37122620 | PMC:PMC10133508 | DOI:10.3389/fnmol.2023.971565

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The Role of Dietary Patterns and Nutritional Supplements in the Management of Mental Disorders in Children and Adolescents: An Umbrella Review of Meta-Analyses: Le rôle des habitudes alimentaires et des suppléments nutritionnels dans la prise en charge des troubles mentaux chez les enfants et les adolescents : une méta-revue de méta-analyses 1 May 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveIn recent years, the relationship between nutrition and mental health has gained considerable interest. We identified, synthesized, and appraised all meta-analyses of randomized controlled trials (RCTs) and observational studies reporting on the efficacy of dietary patterns and nutrient supplements in the prevention and treatment of mental disorders […]
Maria Talib
Investigating Alexithymia as a Moderator of Outcomes in a Randomized Controlled Trial of an Online Intervention for Co-Occurring Depression and Hazardous Alcohol Use: Enquête sur l'alexithymie en tant que modérateur des résultats dans un essai randomisé contrôlé d'une intervention en ligne pour la dépression concomitante et la consommation dangereuse d'alcool 29 April 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveAlexithymia is characterized by difficulty identifying and/or describing emotions, reduced imaginal processes, and externally oriented thinking. High levels of alexithymia may increase the challenge of supporting individuals with co-occurring depression and hazardous alcohol use. This secondary analysis sought to investigate whether or not alexithymia moderated the outcomes […]
Christina Schell
Mental Illness in the 2 Years Prior to Pregnancy in a Population With Traumatic Brain Injury: A Cross-Sectional Study: La maladie mentale dans les deux ans précédant une grossesse dans une population souffrant de lésion cérébrale traumatique : une étude transversale 25 April 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveExisting studies, in mostly male samples such as veterans and athletes, show a strong association between traumatic brain injury (TBI) and mental illness. Yet, while an understanding of mental health before pregnancy is critical for informing preconception and perinatal supports, there are no data on the prevalence […]
Hilary K. Brown

Rapidly expanding gender-affirming care based on consensus instead of evidence justifies rigorous governance and transparency 30 April 2024
Australasian Psychiatry, Ahead of Print. ObjectivePublic services offering gender-affirming care to minors have rapidly expanded across Australia. Despite limited evidence of safety and efficacy, no public information about these services is routinely available. Data from freedom of information requests sent to Australian public gender services for minors is summarised. Gender service numbers increased rapidly in […]
Andrew James Amos
From principles to practice: Clarifying new obligations under Victoria’s Mental Health and Wellbeing Act 2022 30 April 2024
Australasian Psychiatry, Ahead of Print. ObjectiveTo explain the new test for complying with the mental health principles under the Mental Health and Wellbeing Act 2022 (Vic).ConclusionThe principles carry over limitations from the previous Mental Health Act 2014 (Vic) while also containing new features. The ‘all reasonable efforts to comply’ and ‘proper consideration’ tests resemble the […]
Simon Katterl
Recognising inaccuracies in Australian suicide and ‘hidden suicide’ data 24 April 2024
Australasian Psychiatry, Ahead of Print. ObjectiveTo examine the effects of revision of Australian mortality statistics every year since 2007 on numbers and rates of suicide and ‘hidden suicide’.MethodNine months after the end of each year, the Australian Bureau of Statistics releases preliminary statistics concerning deaths registered in that year, together with revised and finalised data […]
John Snowdon

Views held by South African primary health care nurses on caring for people living with mental illness 3 May 2024
Background: Primary healthcare is the first point of entry into the healthcare system. Scaling up primary mental healthcare is recommended in South African mental health policy. However, there is a paucity of data exploring the views of primary healthcare nurses (PHCNs) with regards to caring for people living with mental illness (PLWMI) in South Africa.Aim: To explore […]
Nokukhanya Phungula
Long-term benzodiazepine prescriptions in community psychiatry clinics 3 May 2024
Background: Anecdotal evidence indicates that the prevalence of long-term benzodiazepine prescription is high and not in accordance with accepted prescribing guidelines.Aim: To determine the prevalence of long-term prescriptions of benzodiazepines and associations thereof in community psychiatry clinics.Setting: Of the 27 community psychiatry clinics, 5 were randomly selected.Methods: A descriptive, retrospective, and cross-sectional record review of files of 126 adult […]
Machipi A. Tau
Psychiatric nurses advocating for the human rights of mental health care users in Gauteng 2 May 2024
Background: Psychiatric nurses play an important role in advocating for mental health care users such as advocating for the care, treatment and rehabilitation of mental health care users (MHCUs). Psychiatric nurses face various challenges while advocating for the human rights of MHCUs, particularly those unable to protect their rights because of the severity of their mental […]
Nompumelelo Ntshingila

Sex differences need to be considered when treating women with psychotropic drugs 12 January 2024
World Psychiatry, Volume 23, Issue 1, Page 151-152, February 2024.
Iris E. Sommer, Bodyl A. Brand, Clementine C.M. Stuijt, Daan J. Touw
Can a practical process‐oriented strategy prevent suicidal ideation and behavior? 12 January 2024
World Psychiatry, Volume 23, Issue 1, Page 154-155, February 2024.
Steven C. Hayes, Jacqueline Pistorello
The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline 12 January 2024
World Psychiatry, Volume 23, Issue 1, Page 113-123, February 2024.
Katharina Domschke, Patrik D. Seuling, Miriam A. Schiele, Borwin Bandelow, Neeltje M. Batelaan, Wicher A. Bokma, Igor Branchi, Karl Broich, Julius Burkauskas, Simon J.C. Davies, Bernardo Dell'Osso, Harry Fagan, Naomi A. Fineberg, Toshi A. Furukawa, Stefan G. Hofmann, Sean Hood, Nathan T.M. Huneke, Milan Latas, Nicky Lidbetter, Vasilios Masdrakis, R. Hamish McAllister‐Williams, Antonio E. Nardi, Stefano Pallanti, Brenda W.J.H. Penninx, Giampaolo Perna, Steve Pilling, Stefano Pini, Andreas Reif, Soraya Seedat, Gemma Simons, Shrikant Srivastava, Vesta Steibliene˙, Dan J. Stein, Murray B. Stein, Michael van Ameringen, Anton J.L.M. van Balkom, Nic van der Wee, Peter Zwanzger, David S. Baldwin

Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron 4 May 2024
Molecular Psychiatry, Published online: 04 May 2024; doi:10.1038/s41380-024-02578-6Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron
Wanjing Lai
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission 4 May 2024
Molecular Psychiatry, Published online: 04 May 2024; doi:10.1038/s41380-024-02561-1Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Shani Stern
The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis 3 May 2024
Molecular Psychiatry, Published online: 03 May 2024; doi:10.1038/s41380-024-02573-xThe role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis
Andrew K. May

Keep calm and make neurons: The effects of glucocorticoids on human cortical neurogenesis
Maternal well-being is important for the development of the fetus, with a key influence on its nervous system. In this issue of , Krontira et al. implicate glucocorticoids, the stress hormones, in the regulation of neural stem cell identity and proliferation, with long-lasting consequences on brain architecture and educational attainment.Maternal well-being is important for the development […]
More than meets the eye: A conserved sensorimotor reflex helps unravel the circuit mechanisms of ASD
Animal models are instrumental to understanding the mechanisms underlying autism spectrum disorder, yet translating human behavioral phenotypes remains challenging. Wang et al. leverage a conserved sensorimotor reflex to elucidate synaptic deficits in haploinsufficiency and pilot novel rescue strategies.Animal models are instrumental to understanding the mechanisms underlying autism spectrum disorder, yet translating human behavioral phenotypes remains challenging. […]
Collaterals and stroke reperfusion: Too few leads to too much
Adequate reperfusion after ischemic stroke is a major determinant of functional outcome yet remains unpredictable and insufficient for most survivors. In this issue of , Binder et al. identify leptomeningeal collaterals (LMCs) in mice and human patients as a key factor in regulating reperfusion and hemorrhagic transformation following stroke.Adequate reperfusion after ischemic stroke is a major […]

Rethinking technology innovation for mental health: framework for multi-sectoral collaboration 3 May 2024
Nature Mental Health, Published online: 03 May 2024; doi:10.1038/s44220-024-00232-2In this Perspective, the authors make recommendations on better aligning stakeholders, including those in technology, practitioners and researchers, to increase collaboration and governance in technology and mental health.
Jina Suh
Optimizing real-world benefit and risk of new psychedelic medications: the need for innovative postmarket surveillance 3 May 2024
Nature Mental Health, Published online: 03 May 2024; doi:10.1038/s44220-024-00233-1In this Perspective, authors argue for a more robust and comprehensive postmarket surveillance program of psychedelic-assisted psychotherapy to better ensure safe, appropriate and equitable care for patients.
Joshua C. Black
Ensemble deep learning for Alzheimer’s disease characterization and estimation 3 May 2024
Nature Mental Health, Published online: 03 May 2024; doi:10.1038/s44220-024-00237-xIn this Review, the authors cover the latest understanding of ensemble deep learning models as a means to complement Alzheimer’s disease diagnosis.
M. Tanveer

Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder 27 April 2024
Translational Psychiatry, Published online: 27 April 2024; doi:10.1038/s41398-024-02907-xExploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder
Kaiping Burrows
EZH2-dependent epigenetic reprogramming in the central nucleus of amygdala regulates adult anxiety in both sexes after adolescent alcohol exposure 26 April 2024
Translational Psychiatry, Published online: 26 April 2024; doi:10.1038/s41398-024-02906-yEZH2-dependent epigenetic reprogramming in the central nucleus of amygdala regulates adult anxiety in both sexes after adolescent alcohol exposure
John Peyton Bohnsack
Correction: A genetic risk score to predict treatment nonresponse in psychotic depression 26 April 2024
Translational Psychiatry, Published online: 26 April 2024; doi:10.1038/s41398-024-02912-0Correction: A genetic risk score to predict treatment nonresponse in psychotic depression
Sophie E. ter Hark

Does stereotactic thrombolysis with alteplase for intracerebral haemorrhage alter intraventricular haematoma volume? A secondary analysis of the MISTIE-III trial 26 April 2024
BackgroundStereotactic thrombolysis reduces intracerebral haemorrhage (ICH) volume in patients with spontaneous ICH. Whether intrahaematomal alteplase administration is associated with a change in intraventricular haemorrhage volume (deltaIVH) and functional outcomes is unknown.MethodsPost hoc secondary analysis of the Minimally Invasive Surgery plus Alteplase for Intracerebral Hemorrhage Evacuation Phase III (MISTIE-III) trial in patients with IVH on the […]
Sun, P., Badihian, S., Avadhani, R., Walborn, N., Yarava, A., Alimoradi, D., Awad, I., Hanley, D., Murthy, S., Ziai, W.
Weighing the impact of post hoc studies 26 April 2024
In their JNNP study, Dr Sun et al report post hoc analyses of data from the ‘Minimally Invasive Surgery plus Alteplase for Intracerebral haemorrhage Evacuation trial (MISTIE III)’.1 2 The parent study was a randomised open-label trial comparing image-guided minimally invasive haematoma evacuation followed by alteplase irrigation (MIS+alteplase) to standard medical care. The primary endpoint […]
Furie, K. L.
Genetics impact risk of Alzheimers disease through mechanisms modulating structural brain morphology in late life 25 April 2024
BackgroundAlzheimer’s disease (AD)-related neuropathological changes can occur decades before clinical symptoms. We aimed to investigate whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural brain reserve and/or increasing brain atrophy, respectively.MethodsWe used bidirectional two-sample Mendelian randomisation to estimate the effects between genetic liability to AD and global and regional cortical thickness, estimated […]
Korologou-Linden, R., Xu, B., Coulthard, E., Walton, E., Wearn, A., Hemani, G., White, T., Cecil, C., Sharp, T., Tiemeier, H., Banaschewski, T., Bokde, A., Desrivieres, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillere Martinot, M.-L., Artiges, E., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Millenet, S., Fröhner, J. H., Smolka, M., Walter, H., Winterer, J., Whelan, R., Schumann, G., Howe, L. D., Ben-Shlomo, Y., Davies, N. M., Anderson, E. L.

Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis 7 March 2024
Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood […]
Maksyutynska, Kateryna
Reward anticipation-related neural activation following cued reinforcement in adults with psychotic psychopathology and biological relatives 10 January 2024
BackgroundSchizophrenia is associated with hypoactivation of reward sensitive brain areas during reward anticipation. However, it is unclear whether these neural functions are similarly impaired in other disorders with psychotic symptomatology or individuals with genetic liability for psychosis. If abnormalities in reward sensitive brain areas are shared across individuals with psychotic psychopathology and people with heightened […]
Demro, Caroline
Weight change in people with depression and the risk of dementia: a nationwide cohort study 5 January 2024
BackgroundDepression is a risk factor for dementia and weight change can appear as a symptom of depression. However, the association between weight change after the diagnosis of depression and the risk of dementia is poorly established. This study aimed to investigate the association between weight change before and after a diagnosis of depression with the […]
Kim, Hyewon

Alcohol use disorder and risk of specific methods of suicide death in a national cohort 2 May 2024
Acta Psychiatrica Scandinavica, Volume 149, Issue 6, Page 479-490, June 2024.
Alexis C. Edwards, Linda Abrahamsson, Casey Crump, Jan Sundquist, Kristina Sundquist, Kenneth S. Kendler
A comprehensive analysis of age of onset and cumulative incidence of mental disorders: A Danish register study 2 May 2024
Acta Psychiatrica Scandinavica, Volume 149, Issue 6, Page 467-478, June 2024.
Christoffer Beck, Carsten Bøcker Pedersen, Oleguer Plana‐Ripoll, Søren Dalsgaard, Jean‐Christophe Philippe Debost, Thomas Munk Laursen, Katherine Louise Musliner, Preben Bo Mortensen, Marianne Giørtz Pedersen, Liselotte Vogdrup Petersen, Zeynep Yilmaz, John McGrath, Esben Agerbo
Decreased oxytocin levels related to social cognition impairment in borderline personality disorder 2 May 2024
Acta Psychiatrica Scandinavica, Volume 149, Issue 6, Page 458-466, June 2024.
Alejandra Galvez‐Merlin, José M. López‐Villatoro, Pilar de la Higuera‐González, Alejandro de la Torre‐Luque, Karina McDowell, Marina Díaz‐Marsá, Juan C. Leza, José L. Carrasco

Influence of childhood trauma and traumatic stress on a woman's risk of having a child with a fetal alcohol spectrum disorder 4 May 2024
Alcohol, Clinical and Experimental Research, EarlyView.
Michelle Parker, Philip A. May, Anna‐Susan Marais, Marlene de Vries, Wendy O. Kalberg, David Buckley, Julie Hasken, H. Eugene Hoyme, Soraya Seedat
Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease 4 May 2024
Human Brain Mapping, Volume 45, Issue 7, May 2024.
Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zuo
Mapping brain function in adults and young children during naturalistic viewing with high‐density diffuse optical tomography 4 May 2024
Human Brain Mapping, Volume 45, Issue 7, May 2024.
Kalyan Tripathy, Morgan Fogarty, Alexandra M. Svoboda, Mariel L. Schroeder, Sean M. Rafferty, Edward J. Richter, Christopher Tracy, Patricia K. Mansfield, Madison Booth, Andrew K. Fishell, Arefeh Sherafati, Zachary E. Markow, Muriah D. Wheelock, Ana María Arbeláez, Bradley L. Schlaggar, Christopher D. Smyser, Adam T. Eggebrecht, Joseph P. Culver

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Beyond Psychopharmacology: the Interpersonal Dynamics of Agitation Management
Practical Advice for Preventing Problems When Referencing the Literature
Provision of Cognitive Behavior Therapy for Depression and Anxiety Disorders by Medical Student Trainees
The purpose of the article is to evaluate an innovative education program in which medical students were trained in cognitive behavior therapy (CBT) and provided CBT treatments under supervision to uninsured individuals with depressive, anxiety, adjustment, and trauma-based disorders.The authors assessed improvements in trainees’ CBT knowledge using the Cognitive Therapy Awareness Scale before and after […]

Web-Based Initiatives to Prevent Sexual Offense Perpetration: A Systematic Review
Web-based programs to prevent sexual offense perpetration could provide an opportunity that avoids many of the barriers associated with in-person treatment. The aim of this systematic review is to give an overview of the literature on web-based initiatives aimed at sexual offense perpetration prevention published during the last 10 years (2013–2023) and to report data on […]
Attachment Theory and Sexual Offending: Making the Connection
The purpose of this review is to discuss how attachment theory can be applied to explain sexual violence. Specifically, it discusses how the development of certain risk factors contributes to these behaviors and how attachment-based models can be used to address this issue through prevention and therapeutic interventions.Recent research demonstrates that individuals who commit sexual […]
Dynamic Protective Factors Relevant to Sexual Offending
Focusing on protective factors rather than risk factors potentially better aligns assessment with strengths-based treatment. We examine research into the assessment of protective factors to see whether it can play this role relative to sexual offending.Structured asses sment of protective factors is well developed relative to violent offending but only recently studied relative to sexual […]

Editorial introductions 26 March 2024
No abstract available
Urbanization and psychosis: an update of recent evidence 4 March 2024
Purpose of review Urbanization, a complex global phenomenon, has a significant bearing on schizophrenia/psychosis burden through various socioeconomic and environmental factors. This review focuses on recent evidence (2019–2023) linking urbanization, schizophrenia, and the role of green space. Recent findings This review analyzed 43 articles that examined the correlation between urban birth or upbringing, urban living […]
Shifting the paradigm of social withdrawal: a new era of coexisting pathological and non-pathological hikikomori 28 February 2024
Purpose of review Social withdrawal syndrome, known as “hikikomori,” has been highlighted since the late 1990 s in Japan. Hikikomori is more common in urban areas, and often comorbid with mental disorders, and now spreading throughout the world. In the post-COVID-19 era, not outing is no longer considered pathological in itself as the “new normal,” and […]

When is the best time to screen for perinatal anxiety? A longitudinal cohort study
We evaluated the best time to screen for anxiety during pregnancy or postpartum.Screening in early pregnancy was optimal to identify women with anxiety disorders.Screening in early pregnancy was optimal to identify women who wanted treatment.Screening in early pregnancy was optimal for all five screening tools evaluated.Findings can inform clinical guidelines on when to screen for […]
Daily-level associations between posttraumatic stress disorder symptoms and reactions to retrieving positive autobiographical memories
Eight-eight trauma survivors completed 7 daily surveys on PTSD and positive memory reactions.Same-day PTSD related to more suppression, avoidance, distraction, and thinking about something else.Same-day PTSD related to more cigarette use, craving substances/food, dissociation, risky behaviors, task interference, and arousal.Some prior-day cognitive and behavioral reactions predicted more next-day PTSD and vice versa.Same-day PTSD related to […]
Relationship between anxiety sensitivity and post-traumatic stress symptoms in trauma-exposed adults: A meta-analysis
Given the high rate of trauma exposure among the general population, it is important to delineate the risk factors for post-traumatic stress disorder (PTSD). While historically implicated in panic disorder, anxiety sensitivity is increasingly found to play a role in PTSD. The present review investigated the size of the relationship between anxiety sensitivity and PTSD […]

ADHD medication adherence reduces risk of committing minor offenses in adolescents 3 May 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Paul T. Rosenau, Andrea Dietrich, Barbara J. van den Hoofdakker, Pieter J. Hoekstra
A Bayesian approach for exploring person × environment interaction within the environmental sensitivity meta‐framework 3 May 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Francesca Lionetti, Antonio Calcagnì, Giulio D'Urso, Maria Spinelli, Mirco Fasolo, Michael Pluess, Massimiliano Pastore
Family dysfunction, stressful life events, and mental health problems across development in the offspring of parents with an affective disorder 29 April 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Tiffany Resendes, Mark A. Ellenbogen, Albertine J. Oldehinkel

All medical workers together: For better mental health and primary health care- Posters 29 April 2024
The International Journal of Psychiatry in Medicine, Volume 59, Issue 3_suppl, Page 1S-103S, May 2024.
Physical, psychological, cultural, and pharmacological factors influencing the treatment of patients in primary care settings 25 April 2024
The International Journal of Psychiatry in Medicine, Volume 59, Issue 3, Page 267-269, May 2024.
Harold G Koenig
Psychosocial effects of hidradenitis suppurativa in the literature: A systematic review 22 April 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. Hidradenitis suppurativa (HS) is an inflammatory disorder characterized by painful, deep follicular nodules, abscesses, sinus tracts, and scarring, most commonly presenting in the inguinal, axillary, and anogenital regions. This condition substantially decreases quality of life in affected individuals, resulting in higher rates of psychiatric disorders […]
Elizabeth Richards

Influencing factors of length of stay among repeatedly hospitalized patients with mood disorders: a longitudinal study in China 25 April 2024
Patients with mood disorders usually require repeated and prolonged hospitalization, resulting in a heavy burden on healthcare resources. This study aims to identify variables associated with length of stay(LO...
Feng Xu, Peixia Cheng, Jiaying Xu, Xiaonan Wang, Zhen Jiang, Huiping Zhu, Hua Fan, Qian Wang and Qi Gao
A bibliometric and visual analysis of cognitive function in bipolar disorder from 2012 to 2022 18 April 2024
Bipolar disorder (BD) is a chronic psychiatric disorder that combines hypomania or mania and depression. The study aims to investigate the research areas associated with cognitive function in bipolar disorder ...
Xiaohong Cui, Tailian Xue, Zhiyong Zhang, Hong Yang and Yan Ren
Mortality in Qatari individuals with mental illness: a retrospective cohort study 18 April 2024
There is substantial evidence that people with mental illness have higher mortality rates than the general population. However, most of the studies were from Western countries, and it is not clear whether this...
Sami Ouanes, Lien Abou Hashem, Ibrahim Makki, Faisal Khan, Omer Mahgoub, Ahmed Wafer, Omer Dulaimy, Raed Amro and Suhaila Ghuloum

Psychiatry International, Vol. 5, Pages 188-204: “Once Again It Becomes a Friend in Times of Adversity”: A Qualitative Exploration of Interrelationships between Anorexia Nervosa and Trauma over Ten Years 30 April 2024
Background: The majority of research on the relationship between anorexia nervosa (AN) and trauma has been cross-sectional and quantitative. This study aimed to qualitatively explore how this relationship may shift over time. Methods: A community sample of nine women with a lived experience of AN and trauma were interviewed three times over ten years (1997–2007). […]
Sallee Berry
Psychiatry International, Vol. 5, Pages 169-187: Depressive Disorders and EU Labour Resources—The Problem of Lost Productivity in Highly Developed Economies 16 April 2024
Research has shown that mental disorders in working-age individuals are associated with a significant burden of disability, sickness absence, and presenteeism, resulting in lost productivity. This study aims to assess the impact of depressive disorders on the labour markets in the European Union countries, with a particular focus on the disparities between the ‘old’ and […]
Agnieszka Jakubowska
Psychiatry International, Vol. 5, Pages 154-168: Effects of Gender and Social Network Use on High School Students’ Emotional Well-Being during COVID-19 9 April 2024
Various studies conducted during the COVID-19 pandemic have confirmed changes in online behaviour, with young people increasingly using social networks. This trend appears to correlate with a heightened risk of various psychological and emotional problems. The main aim of this study is to explore the patterns of social network use among high school students amidst […]
Sabina Mandić

Blighted phenomena: Learning to work with the dark. 8 April 2024
Blighted phenomena are understood as derivatives of dark, lonely, injured experiences—those that are often difficult to put into words. These phenomena can manifest in innumerable configurations in patients’ presentations and in the specificity of their developmental struggles and language. The present article aims to describe ways of working with the darkness of blighted experience, through […]
Intimate partner violence: Narratives of attachment relationships and linguistic analysis of emotional schemas through a quali-quantitative approach. 18 January 2024
Intimate partner violence (IPV) is a concerning, widespread issue with serious health, social, and financial consequences. Previous studies highlighted the role of insecure attachment patterns in predicting IPV victimization. This study investigates attachment classifications among women survivors of IPV referred to antiviolence centers, as determined by the Adult Attachment Interview and compare them with a […]
Review of Reading French Psychoanalysis. 25 December 2023
Reviews the book, Reading French Psychoanalysis edited by Dana Birksted-Breen, Sara Flanders, and Alain Gibeault (2010). In this essay, the author discusses eight reviews of Reading French Psychoanalysis. The reviews considered are Cheshire (2010) in the British Journal of Psychotherapy, Forde (2010) in the Revista de Psicoanálisis, Glassgold (2014) in the Psychoanalytic Quarterly, Lefer (2011) […]

Leveraging natural language processing to study emotional coherence in psychotherapy. 18 January 2024
The association between emotional experience and expression, known as emotional coherence, is considered important for individual functioning. Recent advances in natural language processing (NLP) make it possible to automatically recognize verbally expressed emotions in psychotherapy dialogues and to explore emotional coherence with larger samples and finer granularity than previously. The present study used state-of-the-art emotion […]
Bridging the multicultural orientation framework with sexual and gender minority psychotherapy: A mixed studies systematic review. 11 January 2024
Sexual and gender minorities (SGM) experience higher rates of psychological distress and seek psychotherapy at higher rates compared to their heterosexual and cisgender counterparts. However, few therapists are trained on how to provide effective psychotherapy with SGM clients. The multicultural orientation (MCO) framework, which has been linked to improved therapeutic processes and outcomes, may be […]
Validation of the German version of the Comparative Psychotherapy Process Scale. 30 November 2023
The Comparative Psychotherapy Process Scale (CPPS) is a 20-item scale which aims to capture technical features distinguishing cognitive behavioral (CBT) from psychodynamic (PD) psychotherapy (and vice versa) in two corresponding subscales (CBT and PD Subscale). Our objective was to validate a German self-report version of the CPPS regarding a previous psychotherapy session in a psychotherapist- […]

An examination of semantic performance in mild cognitive impairment progressors and nonprogressors. 15 February 2024
Objective: Mild cognitive impairment (MCI) is a risk factor for developing Alzheimer’s disease (AD), and about half of older people with MCI will progress to AD within the next 5 years. The aim of the present study was to compare the semantic performance of MCI progressors (MCI-p) and nonprogressors (MCI-np). The hypothesis was that MCI-p […]
Processing speed in first episode of psychosis and first-degree relatives: A candidate endophenotype of spectrum schizophrenia disorders. 8 February 2024
Objective: The processing speed (PS) is highly impacted in individuals experiencing their first episode of psychosis (FEP). Conducting family studies can help to determine whether PS can serve as an endophenotype of schizophrenia spectrum disorders (SSDs), offering valuable insights into the prevention and diagnosis of SSDs. Method: A comprehensive cognitive battery, encompassing tests for PS, […]
Association between neuropsychological assessment and amyloid status in a clinical setting. 8 February 2024
Objective: Large research cohorts show robust associations between neuropsychological tests and Alzheimer’s disease (AD) biomarkers, but studies in clinical settings are limited. The increasing availability of AD biomarkers to the practicing clinician makes it important to understand the relationship between comprehensive clinical neuropsychological assessment and biomarker status. This study examined concordance between practicing clinical neuropsychologists’ […]

Group identity modulates interbrain synchronization during repeated lottery contest. 11 January 2024
Overbidding in Tullock (1980) lottery contests is a robust finding in laboratory experiments. There exists plenty of evidence that demonstrates the effect of group identity on human behavior. This presents a viable avenue for mitigating or resolving the issue of overbidding. However, the impact of group identity on interbrain interactive mechanisms during lottery contests remains […]
Neurosciences tell us how to be adaptable, creative, and proactive agents in decision making: A pilot study. 7 December 2023
In organizational settings, the decision-making process plays a pivotal role and is interrelated with the capability to adapt to the context, that is, adaptability. In this study, the behavioral, electrophysiological (EEG) frequency bands (i.e., alpha, theta) and self-report correlates of adaptability in the context of decision making were explored on a sample of professionals and […]
Modulating the activity of right temporoparietal junction increased belief-based learning in an economic game. 7 December 2023
Decision making is fundamental to social and economic behavior in the presence of other competing intelligent agents. Such decisions require agents to learn about available rewards and punishments (involving reinforcement learning) and also to anticipate what opponents intend to do (involving belief-based learning). However, the neural mechanisms underlying belief-based learning are relatively poorly understood. To […]

Using technologies to evaluate response style in the competency crisis recommendations for evaluators 3 May 2024
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Graham DanzerForensic Services Division, State of Florida, DCF United States, Orlando, FL, USA
The effects of psychosocial interventions applied to forensic psychiatry patients on social functioning and anger level: a meta-analysis study 2 May 2024
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Elif Güzide EmirzaKübra Gülirmak GülerSevda Uzuna Department of Psychiatry Nursing, Faculty of Health Sciences, Ondokuz Mayıs University, Samsun, Turkeyb Department of Psychiatry Nursing, Faculty of Health Sciences, Gümüşhane University, Turkey
The development of a model of decision-making during an act of serious violence using the Critical Decision Method 28 April 2024
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Trixie MottersheadAlys Wyn GriffithsRajan NathanJon Colea Department of Primary Care and Mental Health, University of Liverpool, UKb Mersey Care NHS Foundation Trust, Liverpool, UKc Division of Neuroscience, School of Medicine and Population Health, The University of Sheffield, UKd Cheshire and Wirral Partnership NHS Foundation Trust, Chester, UK

Experts' decision-making processes in Swedish forensic psychiatric investigations: A case vignette study
It has previously been demonstrated that decisions made by forensic experts can suffer from issues with both bias and poor reliability. The outcome of Swedish forensic psychiatric investigations can have a major impact on the courts' choice of sanction for a mentally disordered offender. These investigations are performed by multi-professional teams of experts, where each […]
Efficiency of psychological interventions in the prevention of suicidal behavior and self-injury in penitentiary population: A systematic review
Suicidal behavior is an important public health problem, with a high prevalence in penitentiary context. Nowadays, there is a wide variety of specific treatment programs, aimed to prevent suicidal and self-injurious behavior in incarcerated people. These programs show relative efficiency depending on the model of the psychological intervention applied. This systematic review evaluates the efficiency […]
Compulsory treatment in Portuguese-speaking countries: An analysis and comparison of the legal framework
Compulsory treatment involves the hospital admission of individuals with mental disorders in appropriate facilities through judicial decisions. However, limited information is available regarding the similarities and differences in compulsory treatment legislation in Portuguese-speaking countries.To analyse the commonalities and differences in compulsory treatment legislation in Portuguese-speaking countries, where Portuguese is the primary official language, including Angola, […]

Cocaine and the port: Utopias of security, urban relations, and displacement of policing efforts in the port of Piraeus
In large commercial seaports policing and security efforts to counter the drug trade, especially cocaine, do not appear to be effective beyond a mere displacement effect. In the port of Piraeus, Greece, (perceived) rising quantities of cocaine have led to calls for further securitisation of the port to curb illicit trafficking. This article will present […]
Individual and environmental contributors to psychological distress during imprisonment
People in prison bear a higher burden of psychiatric morbidity compared with the general population. This study examined the extent to which individual and environmental factors contribute to poor mental health during imprisonment. Participants comprised 1296 randomly selected adults in 15 Belgian prisons. Psychological distress was more common in women than men and peaked during […]
Origin stories: Framing 25 years of Dutch political discourse on child sexual exploitation by tourists and travelers
Sexual exploitation of children in the context of travel and tourism (SECTT) has been described as a serious and growing problem. This study critically analyzes political debates and policy measures proposed by the Dutch government between 1995 and 2020 to combat SECTT. To understand how SECTT is framed in Dutch political discourse, Bacchi's ‘what's the […]

Correction to “Gentrification’s association with police violence and the moderating effects of race” by Harmon-Darrow et al. (2023). 2 May 2024
Reports an error in "Gentrification’s association with police violence and the moderating effects of race" by Caroline Harmon-Darrow, Hyun-Jin Jun and Charlotte Lyn Bright (Psychology of Violence, 2023[May], Vol 13[3], 183-193). In the article, corrections to some findings were needed. For the Gentrification Revitalization × Race and the Gentrification Disruption × Race interactions (reported in […]
Perceived victimhood shapes support for interpartisan political violence in the United States. 21 March 2024
Objective: Understanding the drivers of political violence is critical, given the destructive consequences it has on the fabric of society. Prior work has established the importance of situational and dispositional predictors of political violence, such as search for significance and meaning and experiencing trauma. However, these predictors do not fully account for one of its […]
Sexual victimization of autistic college students. 18 March 2024
Objective: Researchers have demonstrated a link between autism and victimization, but less research has explored rates of sexual victimization among autistic college students. Informed by lifestyle-routine activity theory, certain features of autism may enhance vulnerability to sexual victimization and may lead autistic individuals to be targeted by potential perpetrators. Method: Using data from the American […]

Harm from the drinking of people you know: A range of effects from different relationships 3 May 2024
Addiction, EarlyView.
Anne‐Marie Laslett, Dan Anderson‐Luxford, Bree Willoughby, Robin Room, Chris Doran, Diana Egerton‐Warburton, Rebecca Jenkinson, Koen Smit, Heng Jiang
Harmful compared to what? The problem of gaming and ambiguous causal questions 3 May 2024
Addiction, EarlyView.
Kristoffer Magnusson, Fred Johansson, Andrew K. Przybylski
Impact of the disruption in supply of varenicline since 2021 on smoking cessation in England: A population study 30 April 2024
Addiction, EarlyView.
Sarah E. Jackson, Jamie Brown, Harry Tattan‐Birch, Lion Shahab

Development of the social dimensions of health behaviour framework 29 April 2024
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Ryan E. RhodesMark R. Beauchampa Behavioural Medicine Laboratory, School of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC, Canadab School of Kinesiology, University of British Columbia, Vancouver, BC, Canada
A systematic review of the studies testing the integrated motivational-volitional model of suicidal behaviour 16 April 2024
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Kenvil SouzaEdward M. SosuScott ThomsonSusan Rasmussena Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UKb Strathclyde Institute of Education, University of Strathclyde, Glasgow, UK
Mindfulness-based psychosocial interventions and psychological wellbeing in cancer survivorship: a meta-analysis 2 April 2024
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Rachel TellesBrendan M. WhitneySarah FroelichSusan K. Lutgendorfa Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, USAb Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USAc Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA

Domestic violence against women during COVID-19 pandemic and its associated factors among Bench Sheko zone, southwest Ethiopia 19 April 2024
Domestic violence is an intimate relationship that causes physical, sexual or mental suffering. The ongoing coronavirus pandemic has had a ruinous effect globally, particularly in increasing the rate of domestic violence. Thus, this study aims to assess the prevalence of domestic violence against women during the COVID-19 pandemic and its associated factors. A community-based cross-sectional […]
Gebremeskel Mesafint
The sociocultural impact of COVID-19 on registered nurses employed at a regional health authority in a Caribbean island 2 April 2024
The purpose of this study is to examine the sociocultural implications of caring for persons with COVID-19 in a developing country context. In total, 156 nurses participated in the study. Stratified random sampling methodology was used. Data were collected via online self-administered questionnaire. Descriptive and inferential statistics, including ANOVA tests were done. Nurses experienced stigmatization, […]
Corey Dillon
Editorial: 25 years on 2 April 2024
Editorial: 25 years on
Julian Ashton

‘Early childhood autism, Asperger type’, by H. Asperger (1982) 29 April 2024
History of Psychiatry, Ahead of Print. After his 1944 thesis, Asperger continued to write about autism, but none of these texts have been translated. At a time when autism spectrum disorder faces many challenges (e.g. the nature and measurement of autism), this text tells us more about the particular population that Asperger worked with. He […]
Kevin Rebecchi
Landmarks in the history of neurosyphilis: the neglected observations of Vincenzo Chiarugi 24 April 2024
History of Psychiatry, Ahead of Print. After the emergence of syphilis in Europe in 1495, it would take over 400 years to unpick the full course of the infection, including the involvement of the brain and spinal cord. This syndrome of mental and physical deterioration was called ‘general paralysis of the insane’ (GPI). Traditionally, the […]
Daniel Di Francesco
Historical and conceptual features of acute polymorphic psychosis: a myth of European psychiatry from bouffée délirante to ICD-11 acute and transient psychotic disorder 20 April 2024
History of Psychiatry, Ahead of Print. This paper deals with the history and epistemology of acute polymorphic psychosis. We undertook a comparative study of short-lived psychotic disorders used in different European countries since the late nineteenth century. The theory of degeneration offered a speculative basis to conceptualization of conditions such as bouffée délirante, cycloid psychosis […]
Augusto C Castagnini

In memoriam António Bento (1954–2023): Champion of the loveless homeless in Portugal, veteran member of Santé Mentale et Exclusion Sociale (SMES) in Europe 30 April 2024
International Journal of Social Psychiatry, Ahead of Print.
João Gama Marques
The community health worker experience and perception toward mental illness: A multi-settings cross-sectional study in Indonesia 29 April 2024
International Journal of Social Psychiatry, Ahead of Print. Background:The experiences and perceptions of Community Health Workers toward mental illness are vital for tailoring interventions, reducing stigma, improving access to services, and fostering community engagement in mental health initiatives.Aims:This study investigates the experiences of community health worker and their perception of mental illness.Methods:A multi-settings cross-sectional study […]
Marthoenis Marthoenis
Disease, illness, phenomenology and narratives 16 April 2024
International Journal of Social Psychiatry, Volume 70, Issue 3, Page 413-414, May 2024.
Dinesh Bhugra

Where I'm Livin’ and How I'm Feelin’: Associations among community stress, gender, and mental-emotional health among Black Americans
The ADI was positively related to mental health among Black women in Milwaukee.However, neighborhood (dis)cohesion helps account for ADI's unexpected links to these outcomes.Perceived neighborhood disadvantage was related to poorer mental health for Black men and women. Structural racism is a primary avenue for the perpetuation of racial health disparities. For Black Americans, both historically […]
Health and well-being of young mothers displaced by conflict: Experiences from South Sudan and the Kurdistan Region of Iraq
Giving birth during adolescence is linked to a variety of negative outcomes, including poor health and well-being. Girls who have been displaced by conflict are at increased risk for becoming young mothers. While prevalence rates and health outcomes have been documented, rarely have the complex personal narratives of early motherhood been examined particularly in the […]
Intergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi
Thirty years after the 1994 genocide against the Tutsi in Rwanda, children of survivors are being increasingly documented to be at higher risk compared to their peers for adverse mental health outcomes. However, no studies in Rwanda have empirically explored family psychosocial factors underlying this intergenerational transmission of trauma. We investigated family psychosocial factors that […]

When my neighborhood woke up: Knitting collective action in disadvantaged areas amid the 2019 Chilean uprising. 15 April 2024
October 2019 saw the birth of the largest wave of demonstrations to hit Chile in the last 50 years. Protesters, the length of the country, soon joined in, voicing a broad range of demands and driving what has been described as a true “awakening” at the local level. This local dimension of the protests—that is, […]
Clarification notice to “The geography of military occupation and its effect on Palestinian community cohesion, norms, and resistance motivation” by Penić et al. (2023). 15 April 2024
Reports a clarification to "The Geography of Military Occupation and its Effect on Palestinian Community Cohesion, Norms, and Resistance Motivation" by Sandra Penić, Johanna Ray Vollhardt, Karsten Donnay, Mai Albzour and Ravi Bhavnani (Peace and Conflict: Journal of Peace Psychology, Advanced Online Publication, Jun 22, 2023, np). The authors wish to clarify the relationship between […]
School as a contested territory for citizenship: An ethnographic study of illegal occupation and protest processes at a popular vocational education school in the chilean october. 15 April 2024
The sociopolitical crisis that flared up in Chile starting in October 2019 laid bare tensions in how different social groups understand citizenship and political mobilization. These tensions evinced clear generational differences coupled with the emergence of new forms of understanding and doing politics among youth. This article presents the results of an ethnographic study conducted […]

Concretization as a possible mechanism of nightmare proneness: Some theoretical considerations and empirical findings. 28 March 2024
Nightmare proneness, a disposition to experience frequent nightmares, has been found to predict nightmares independent of neuroticism, psychological distress, and trauma symptoms. One theorized mechanism of nightmare proneness is concretization, a hypothetical defensive style in which vague and unpleasant inner states are made more tangible. The possible role of concretization in nightmare proneness and nightmares […]
Nightmare types and suicide. 28 March 2024
Previous research has robustly documented the relationship between sleep and suicide, where many aspects of poor sleep quality, sleep disturbances, and sleep disorders have been found to predict suicide. Research has also linked nightmares to suicide. It is not known, however, if nightmare types (idiopathic, trauma-related, and complex nightmares [nightmares with comorbid sleep and breathing […]
Veteran treatment completers’ and facilitators’ perceptions of cognitive behavioral therapy for insomnia and imagery rehearsal therapy for posttraumatic sleep disturbances. 13 November 2023
Cognitive behavioral therapy for insomnia (CBT-I) and imagery rehearsal therapy are recommended cognitive-behavioral treatments. However, little is known about the acceptability of the treatments for veterans with posttraumatic sleep disturbances. This study was conducted after a pilot randomized controlled trial that compared CBT-I with CBT-I combined with imagery rehearsal therapy (IRT) in a sample of […]

Medicare Drug Price Negotiation; Diagnostic Errors 4 May 2024
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center...
What If States Paid People to Stop Using Drugs and Smoking? 4 May 2024
(MedPage Today) -- The U.S. is grappling with two leading and interwoven crises of addiction that result in far too many preventable deaths each year. While one is a problem that the country has been battling for decades, the other is relatively...
Alzheimer's Biomarkers Linked With Plasma Leptin Levels 3 May 2024
(MedPage Today) -- Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults, a longitudinal cohort study in Korea showed. Over 2 years, lower baseline plasma leptin was associated with a greater...

Psychiatric hospital's troubles grow, in arbitration over millions - The Daily Sentinel 5 May 2024
As western Colorado's only psychiatric hospital edges closer to a possible shut down, its parent company — Mind Springs Health — is in arbitration ...
How Much Stress Is Too Much? A Psychiatrist Explains the Links Between Toxic Stress and ... 5 May 2024
I'm a psychiatrist specializing in psychosomatic medicine, which is the study and treatment of people who have physical and mental illnesses.
Team Hope Walk raises awareness for Huntington's Disease - KCRG 5 May 2024
Psychiatry ...

Somalia: Floods - Apr 2024 19 April 2024
Affected country: Somalia Glide: FL-2024-000055-SOM The Gu (April to June) rains are intensifying with flash floods reported since 19 April. Four people, three boys in Somaliland and a six-year-old girl in Hirshabelle State have been reportedly killed; about 100 shelters for displaced people destroyed and at least 134 families (804 people) affected or displaced across […]
Indonesia: Ruang Volcano - Apr 2024 16 April 2024
Affected country: Indonesia Glide: VO-2024-000046-IDN Ruang volcano, located on Ruang Island (part of Sangihe Islands, North Sulawesi Province), increased its volcanic activity on 16-17 April with explosions and emission of volcanic ash and lava. The worst hit areas are Pumpente Village and Pathology Village in Tagulandang District (Sitaro Islands Regency, North Sulawesi Province). According to […]
Kenya: Floods - Apr 2024 9 April 2024
Affected country: Kenya Glide: FL-2024-000045-KEN The last week of March marked the start of the long rains season (March to May) characterised by isolated heavy storms that caused heavy rainfall and flash floods in several parts of the country. At least 13 people have died, nearly 3,000 households displaced, over 339 livestock killed, and unknown […]

Marcel Hug, world champion and Swiss Paralympic wheelchair racer, to take part in Walk the Talk Geneva 3 May 2024
Swiss Paralympic wheelchair racer, world champion Marcel Hug, has announced his participation in the 5th WHO Walk the Talk: Health for All Challenge event in Geneva on Sunday 26 May 2024.
who.int
World Hand Hygiene Day 2024 - why is sharing knowledge about hand hygiene still so important? 1 May 2024
WHO Infection Prevention and Control Global Webinar Please join us6 May 2024, 2:00-3:30 pm CETWorld Hand Hygiene Day 2024 - why is sharing knowledge about hand hygiene still so important?In the context of a multimodal improvement strategy, WHO highlights the importance of training of health workers for sustainable improvement in infection prevention and control (IPC), […]
who.int
Sexual and reproductive health and rights: central to health, well-being and sustainable futures 30 April 2024
This event will champion evidence, experience and action to advance SRHR as central to health and sustainable development, and examine inclusive solutions to address wider challenges of stigma, inequalities and political division.
who.int

Rafah incursion would substantially increase mortality and morbidity and further weaken an ... 3 May 2024
3 May 2024 – WHO is deeply concerned that a full-scale military operation in Rafah could lead to a bloodbath. More than 1.2 million people are currently sheltering in the area, many unable to move anywhere else. A new wave of displacement would exacerbate overcrowding, further limiting access to food, water, health and sanitation services, leading to […]
50 years of EPI’s extraordinary impact on global health 1 May 2024
24 April 2024, Cairo, Egypt – World Immunization Week this year coincides with the 50th anniversary of the Expanded Programme on Immunization (EPI). Such has been the programme’s remarkable impact on global health that the “E” in EPI today stands for “Essential”. Since 1974, this WHO initiative has inspired countries to use vaccines to do […]
Opening statement by Director of Programme Management at the World Immunization Week press ... 29 April 2024
Distinguished guests, esteemed colleagues, and members of the media, We warmly welcome you to this press conference to mark World Immunization Week. This year, the week coincides with a remarkable milestone – 50 years of the Expanded Programme on Immunization, or EPI. When launched in 1974, this WHO initiative started out with a limited series […]

Disasters Forced 2.5 Million Americans From Their Homes Last Year 22 February 2024
Many of those displaced also reported food shortages and predatory scams, according to new data from the Census Bureau.
Aidan Gardiner
U.S. Hit by Record Number of High-Cost Disasters in 2023 19 February 2024
There were 28 storms, wildfires or other disasters that each cost at least one billion dollars in damages, a sign of the growing economic burden of climate change.
Christopher Flavelle
Biden Offers Aid to California as It Deals with Floods and Mudslides 6 February 2024
The president addressed the public via Los Angeles Mayor Karen Bass’s speakerphone to offer aid from FEMA after a deadly atmospheric river hit the state.

Interplay of age, gender, education, and heart rate in dementia among older adults in Wakiso, Uganda: a cross sectional study [version 1; peer review: awaiting peer review] 3 May 2024
Background In this cross-sectional study conducted in Wakiso, Uganda, from May to July 2023, we investigated the interactions among age, sex, education, and heart rate in relation to dementia and Mild Cognitive Impairment (MCI) among individuals aged 65 years and older. Methods We purposively sampled 106 participants, focusing on those with Alzheimer’s disease and related […]
Kamada Lwere
Case Report: Methimazole-Induced Parotitis - An Unusual and Rare Presentation of Thyroid Storm [version 1; peer review: awaiting peer review] 3 May 2024
A 56-year-old female with a medical history of unspecified hyperthyroidism and a recent thyroid storm presented to the ED with tachycardia, hypertension, and bilateral enlarged parotid glands. During a previous hospitalization, she was diagnosed with unspecified hyperthyroidism and started on methimazole. During hospitalization, laboratory findings suggested Graves’ disease with an acute thyroid storm. The patient […]
Ricky Rana
The top 50 most-cited articles about COVID-19 and the complications of COVID-19: A bibliometric analysis [version 3; peer review: 1 approved with reservations] 3 May 2024
Background This bibliometric analysis examines the top 50 most-cited articles on COVID-19 complications, offering insights into the multifaceted impact of the virus. Since its emergence in Wuhan in December 2019, COVID-19 has evolved into a global health crisis, with over 770 million confirmed cases and 6.9 million deaths as of September 2023. Initially recognized as […]
Tanya Singh

Market Sustainability and Improvement Fund 2024 to 2025 3 May 2024
Sets out the guidance to support local authorities in administering the Market Sustainability and Improvement Fund in 2024 to 2025.
HM Government
Medicines eligible for Northern Ireland MHRA Authorised Route 2 May 2024
Sets out medicines that can be moved to Northern Ireland to meet patient need.
HM Government
Department of Health and Social Care – Working for DHSC 2 May 2024
We offer a varied, exciting, challenging and rewarding working environment.
HM Government

Understanding the new income statistics for local areas: Different measures for better insights 30 April 2024
The ONS has been busy producing faster, more detailed statistics using new data sources. Providing clearer insights at the local level is an important aspect of this work. Ainslie Woods explains how our local income statistics compare and why they offer a complementary picture of local areas.
croydl
Exploring findings from the Winter COVID-19 Infection Study 25 April 2024
In November 2023 ONS and UK Health Security Agency (UKHSA) launched the Winter COVID-19 Infection Study (Winter CIS) to gather vital data on levels of the virus in the colder months. James Tucker explores some of the findings and takes a deeper look at what they can tell us about ongoing symptoms and risk factors.
lornatipper
Our changing population is there for all to see 12 April 2024
From finishing studies to entering the workforce, from getting married to earning the most money - everyone’s journey through adulthood is different. However, we can use a range of data to explore when key events in life are most likely to happen. Rich Pereira looks at how these milestones of adulthood have changed over the […]
samcollin

Advanced Mobile Solutions (AMS) guidance trailer 1 May 2024
Chris P explains how AMS will enable high-threat organisations to stay connected ‘on the go'.
Business email compromise: defending your organisation 29 April 2024
How to disrupt email phishing attacks that target senior executives or budget holders.
Smart devices: new law helps citizens to choose secure products 29 April 2024
Download the NCSC’s point-of-sale leaflet explaining how new PSTI regulation affects consumers and retailers.

Judge warns over “dangerously high” hormone dose prescribed to teenager by online gender clinic 3 May 2024
The judge who heads the High Court’s family division has warned of the risks of obtaining hormone prescriptions from online gender clinics, after an expert witness told the court that a teenager had received “dangerously high” amounts of testosterone.1Giving judgment in the case of “J,” to whom testosterone was prescribed at the age of 15, […]
Clare Dyer
Saying hello to patients: there is no “one size fits all” approach 3 May 2024
Launer makes a good point about the benefit of acknowledging patients with a simple “hello.”1There is no doubt that an unexpected greeting can make the recipient smile and feel recognised and that human interaction also gives the person saying hello a boost. This is becoming increasingly relevant in the modern world, where people can walk […]
Andrew G Affleck
US expert panel says breast cancer screening should begin at 40 3 May 2024
Women in the US should begin breast cancer screening with mammography at age 40 and be screened every other year until the age of 74, the US Preventive Services Task Force has recommended.1 US doctors typically follow the task force’s recommendations.The task force said that more research was needed about whether additional screening might be […]
Janice Hopkins Tanne

High-Dose Prednisone Can Reduce Rate of Pregnancy 4 May 2024
"I almost didn't believe the data," author of new study said. Medscape Medical News
Office Procedure Found to Get Stone Fragments Rolling 4 May 2024
The novel ultrasound device resolved lingering kidney stones and prevented relapse in a new study. Medscape Medical News
In Angina, Gene Therapy Coaxes Heart Vessel Growth 3 May 2024
The experimental new approach, delivered to the heart of those with angina after bypass surgery, showed evidence of restored blood flow 1 year later. Medscape Medical News

Confronting the high stakes of incivility in health care 22 April 2024
On this episode of the CMAJ Podcast, Dr. Eve Purdy makes it clear what’s at stake when it comes to incivility in medicine. "It's very simple. Incivility kills patients, and that needs to be the single line of every healthcare leader responsible for managing and leading teams.” Dr. Purdy joins Dr. Sarah Kim and hosts, […]
Canadian Medical Association Journal
Diagnosis and treatment of anorexia nervosa in adolescent males 8 April 2024
On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole closely examine anorexia nervosa in male adolescents, a topic that frequently escapes notice. Their discussion highlights the disorder's prevalence, especially among high-risk groups like LGBTQ+ individuals and those from varied racial and ethnic backgrounds. It also underscores the severity of anorexia […]
Canadian Medical Association Journal
Diagnosing rare and common infections in returning travellers 25 March 2024
On this episode, Dr. Blair Bigham and Dr. Mojola Omole explore a clinical case involving a rare infection in a returned traveler, highlighting the critical role of travel history in diagnosing unusual diseases. They discuss the case of a woman in her 60s who presented with fever and ankle pain after returning from India. Initial […]
Canadian Medical Association Journal

Europe: Report highlights direct link between pandemic and childhood obesity 1 May 2024
The COVID-19 pandemic has led to increased obesity in school-aged children in Europe, the World Health Organization (WHO) office for the region said in a new report issued on Wednesday, sounding the alarm for action.
‘Just in case’ antibiotics widely overused during COVID-19, says UN health agency 26 April 2024
Antibiotics saw “extensive overuse” globally among hospitalised COVID-19 patients during the pandemic without improving clinical outcomes, while also potentially increasing the already serious and growing threat of antimicrobial resistance from "superbugs", the UN World Health Organization (WHO) said on Friday.
Teen alcohol and nicotine use in Europe is up, WHO urges preventive measures 25 April 2024
Smoking and drinking is on the rise among teenagers in Europe, Central Asia and Canada, and girls now match or even exceed boys when it comes to substance use, the World Health Organization (WHO) said in a new report on Thursday.

Humberside police misconduct hearing finds that surveillance of Janet Alder was unlawful but concludes with ‘no case to answer’ for officers involved 4 May 2024
1 March 2018
Inquest
Chelsea Bridge death: The family of Oladeji Omishore raise concerns about misinformation 4 May 2024
22 June 2022 Oladeji “Deji” Omishore died on 4 June 2022 following contact with two Metropolitan Police Officers on Chelsea Bridge, following multiple use of Taser. Deji was within sight of his apartment on the embankment, when the officers apprehended him. A bystander video of Deji being Tasered and subsequently falling into the River Thames […]
Inquest
JERMAINE BAKER: Public inquiry report issues ‘a loud wake-up call to a newly appointed commissioner’ 4 May 2024
5 July 2022
Inquest