Evidence
Food Funct. 2024 Mar 18. doi: 10.1039/d3fo04760a. Online ahead of print.
ABSTRACT
The Mediterranean diet (MD), characterized by olive oil, olives, fruits, vegetables, and wine intake, is associated with a reduced risk of dementia. These foods are rich in bioactives with neuroprotective and antioxidant properties, including hydroxytyrosol (HT), tyrosol (TYRS), serotonin (SER) and protocatechuic acid (PCA), a phenolic acid metabolite of anthocyanins. It remains to be established if these molecules cross the blood-brain barrier (BBB), a complex interface that strictly controls the entrance of molecules into the brain. We aimed to assess the ability of tyrosine (TYR), HT, TYRS, PCA and SER to pass through the BBB without disrupting its properties. Using Human Brain Microvascular Endothelial Cells as an in vitro model of the BBB, we assessed its integrity by transendothelial electrical resistance, paracellular permeability and immunocytochemical assays of the adherens junction protein β-catenin. The transport across the BBB was evaluated by ultra-high-performance liquid chromatography high resolution mass spectrometry. Results show that tested bioactives did not impair BBB integrity regardless of the concentration evaluated. Additionally, all of them cross the BBB, with the following percentages: HT (∼70%), TYR (∼50%), TYRS (∼30%), SER (∼30%) and PCA (∼9%). These results provide a basis for the MD neuroprotective role.
PMID:38497922 | DOI:10.1039/d3fo04760a
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
In vitro study of the blood-brain barrier transport of bioactives from Mediterranean foods
🌐 90 Days
VR Related Evidence Matrix
- Alterations of the blood-brain barrier during aging
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Dietary patterns and carotenoid intake: Comparisons of MIND, Mediterranean, DASH, and Healthy Eating Index
- C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity
- Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
- Alcohol binge drinking induces downregulation of blood-brain barrier proteins in the rat frontal cortex -but not in the hippocampus- that is not prevented by OEA pretreatment
- Diet, food, and nutritional exposures and inflammatory bowel disease or progression of disease: an umbrella review
- Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?
- Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR delta activation
- Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption
- Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice
- Placenta-brain communication in preeclampsia. What we have learnt from preclinical models.
- Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development
- Effects of Ferulic Acid on Cognitive Function: A Systematic Review
- Engineered Wnt7a ligands rescue blood-brain barrier and cognitive deficits in a COVID-19 mouse model
- Plasma of COVID-19 Patients Does Not Alter Electrical Resistance of Human Endothelial Blood-Brain Barrier In Vitro
- Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
- Blood-brain barrier breakdown and autoimmune cerebellar ataxia
- Treatment with RNase alleviates brain injury but not neuroinflammation in neonatal hypoxia/ischemia
- Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation
- Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review
- Vegetables, fruits, and berries - a scoping review for Nordic Nutrition Recommendations 2023
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- Simultaneous Intake of Chlorella and Ascidian Ethanolamine Plasmalogen Accelerates Activation of BDNF-TrkB-CREB Signaling in Rats
- The antioxidant peptides from walnut protein hydrolysates and their protective activity against alcoholic injury
- Phytochemical Profiling and Biological Activities of Pericarps and Seeds Reveal the Controversy on "Enucleation" or "Nucleus-Retaining" of Cornus officinalis Fruits
- Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe
- Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood-brain barrier damage in ducks during Riemerella anatipestifer infection
- Neutrophil Targeting Platform Reduces Neutrophil Extracellular Traps for Improved Traumatic Brain Injury and Stroke Theranostics
- Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model
- Gamma-aminobutyric acid as a potential postbiotic mediator in the gut-brain axis
- Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism
- Binary Nano-inhalant Formulation of Icariin Enhances Cognitive Function in Vascular Dementia via BDNF/TrkB Signaling and Anti-inflammatory Effects
- Dietary patterns associated with hypertension among stroke-free indigenous Africans: insights from the Stroke Investigative Research and Educational Network study
- Inclusion complex of quercetin with sulfobutylether β-cyclodextrin: preparation, characterization, antioxidant and antibacterial activities and the inclusion mechanism
- Neural and Onconeural Autoantibodies and Blood-Brain Barrier Disruption Markers in Patients Undergoing Radiotherapy for High-Grade Primary Brain Tumour
- The MIND diet for the ageing brain: a systematic review
- A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE-/- mice
- A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE-/- mice
- BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy
- trans-Palmitoleic acid promotes adipose thermogenesis to reduce obesity via hypothalamic FFAR1 signaling
- Extracts of tropical green seaweed Caulerpa lentillifera reduce hepatic lipid accumulation by modulating lipid metabolism molecules in HepG2 cells
- A CDAHFD-induced mouse model mimicking human NASH in the metabolism of hepatic phosphatidylcholines and acyl carnitines
- Dietary Polyphenols: What is the Estimated Intake in Population Studies With Adults and Elderly People?
- Cholinergic neurotransmission controls orexigenic endocannabinoid signaling in the gut in diet-induced obesity
- Are eco-sustainable dietary patterns associated with impulsiveness? An insight from Italy
- iPSC-derived models for anorexia nervosa research
- Cell-mediated nanoparticle delivery systems: towards precision nanomedicine
- Effects of Phenolic Evolution on Color Characteristics of Single-Cultivar Vitis vinifera L. Marselan and Merlot Wines during Vinification and Aging
- Fructose induces hepatic steatosis in adolescent mice linked to the disorders of lipid metabolism, bile acid metabolism, and autophagy
- Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions
- Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS
- Feasibility of measuring blood-brain barrier permeability using ultra-short echo time radial magnetic resonance imaging
- The microbiota-gut-brain axis: A crucial immunomodulatory pathway for Bifidobacterium animalis subsp. lactis' resilience against LPS treatment in neonatal rats
- Fruit and vegetable intake and risk of disabling dementia: JPHC Disabling Dementia Study
- Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
- Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice
- Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice
- Whole Genome Mining and Characterization of a New Probiotic Strain Levilactobacillus brevis ILSH3 from Handia: An Ethnic Fermented Beverage of Odisha, India
- Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder
- Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
- Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells
- Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis
Evidence Blueprint
In vitro study of the blood-brain barrier transport of bioactives from Mediterranean foods
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
Save Evidence Blueprint
Save as PDF
In vitro study of the blood-brain barrier transport of bioactives from Mediterranean foods
🌐 365 Days
VR Related Evidence Matrix
- Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB
- Blood-brain barrier disruption in dementia: Nano-solutions as new treatment options
- Alterations of the blood-brain barrier during aging
- (Poly)phenol intake, plant-rich dietary patterns and cardiometabolic health: a cross-sectional study
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Association between adherence to the Mediterranean diet with cardiometabolic risk factors: a cross-sectional study on PERSIAN cohort study in Fasa
- Neuroprotective mechanisms of defatted walnut powder against scopolamine-induced Alzheimer's disease in mice revealed through metabolomics and proteomics analyses
- What We Know about Euterpe Genus and Neuroprotection: A Scoping Review
- Dietary patterns and carotenoid intake: Comparisons of MIND, Mediterranean, DASH, and Healthy Eating Index
- Not open and shut: Complex and prolonged blood-brain barrier responses after stroke
- CD98hc is a target for brain delivery of biotherapeutics
- Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy
- C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity
- Manufactured tissue-to-tissue barrier chip for modeling the human blood-brain barrier and regulation of cellular trafficking
- Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
- Alcohol binge drinking induces downregulation of blood-brain barrier proteins in the rat frontal cortex -but not in the hippocampus- that is not prevented by OEA pretreatment
- Diet, food, and nutritional exposures and inflammatory bowel disease or progression of disease: an umbrella review
- Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?
- Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR delta activation
- Association between alcoholic (poly)phenol-rich beverage consumption and cognitive status in older adults living in a Mediterranean area
- Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption
- A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut-brain axis
- Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism
- Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants
- Moderate red wine intake and cardiovascular health protection: a literature review
- Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
- Correction of gut dysbiosis as a promising direction in the prevention of neuroinflammation and cognitive impairment
- Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice
- Meta-analysis of the association between major foods with added fructose and non-alcoholic fatty liver disease
- Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice
- Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment
- Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study
- Blood-Brain Barrier Integrity Is Perturbed in a Mecp2-Null Mouse Model of Rett Syndrome
- Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review
- Placenta-brain communication in preeclampsia. What we have learnt from preclinical models.
- Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development
- Evolution of the diet and physical activity of university students after the COVID-19 pandemic
- Effects of Ferulic Acid on Cognitive Function: A Systematic Review
- Engineered Wnt7a ligands rescue blood-brain barrier and cognitive deficits in a COVID-19 mouse model
- Technological and health properties and main challenges in the production of vegetable beverages and dairy analogs
- Identifying foods that optimize intake of key micronutrients during pregnancy
- Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression
- Blood-brain barrier pathology in cerebral small vessel disease
- Plasma of COVID-19 Patients Does Not Alter Electrical Resistance of Human Endothelial Blood-Brain Barrier In Vitro
- Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
- Blood-brain barrier breakdown and autoimmune cerebellar ataxia
- An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life
- Treatment with RNase alleviates brain injury but not neuroinflammation in neonatal hypoxia/ischemia
- Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation
- Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review
- Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review
- Ethyl Carbamate in Fermented Food Products: Sources of Appearance, Hazards and Methods for Reducing Its Content
- Investigating the origin of the 13 C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13 C]pyruvate injection
- Alcohol consumption patterns and adherence to the Mediterranean diet in the adult population of Spain
- Single-cell control mechanism of brain angiogenesis and blood-brain barrier formation
- Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury
- Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs
- Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein
- Minocycline effects on memory and learning impairment in the beta-amyloid-induced Alzheimer's disease model in male rats using behavioral, biochemical, and histological methods
- Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation
- Vegetables, fruits, and berries - a scoping review for Nordic Nutrition Recommendations 2023
- Foods and beverages associated with smoking craving in heated tobacco product and cigarette smokers: A cross-sectional study
- Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics