Evidence
DNA Repair (Amst). 2024 Jan 24;135:103634. doi: 10.1016/j.dnarep.2024.103634. Online ahead of print.
ABSTRACT
The maintenance of genome stability is crucial for cell homeostasis and tissue integrity. Numerous human neuropathologies display chronic inflammation in the central nervous system, set against a backdrop of genome instability, implying a close interplay between the DNA damage and immune responses in the context of neurological disease. Dissecting the molecular mechanisms of this crosstalk is essential for holistic understanding of neuroinflammatory pathways in genome instability disorders. Non-neuronal cell types, specifically microglia, are major drivers of neuroinflammation in the central nervous system with neuro-protective and -toxic capabilities. Here, we discuss how persistent DNA damage affects microglial homeostasis, zooming in on the cytosolic DNA sensing cGAS-STING pathway and the downstream inflammatory response, which can drive neurotoxic outcomes in the context of genome instability.
PMID:38290197 | DOI:10.1016/j.dnarep.2024.103634
Add to Google Keep
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Microglial inflammation in genome instability: A neurodegenerative perspective
🌐 90 Days
VR Related Evidence Matrix
- Genomic stress and impaired DNA repair in Alzheimer disease
- Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders
- Interaction between central nervous system and immune system after ischemic stroke and its therapeutic significance of traditional Chinese medicine
- FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
- Glial Cell Development and Function in the Zebrafish Central Nervous System
- Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
- Variations in 3D genome structure between homologous chromosomes and in stimulus responses
- Variations in 3D genome structure between homologous chromosomes and in stimulus responses
- Cross-regulation between the immune system and the extracellular matrix during lung pathology
- Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model
- Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies
- Innate immune activation in neurodegenerative diseases
- The major histocompatibility complex participates in Parkinson's disease
- The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
- Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation
- Hypoxia inducible factor-1a regulates microglial innate immune memory and the pathology of Parkinson's disease
- Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
- Postnatal epigenome-mediated aging control and global trends
- Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
- Genes in Axonal Regeneration
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Implication of system xc- in neuroinflammation during the onset and maintenance of neuropathic pain
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Alterations of Gastrointestinal Microbe Composition in Various Human Diseases and Its Significance in the Early Diagnosis of Diseases
- Alterations of Gastrointestinal Microbe Composition in Various Human Diseases and Its Significance in the Early Diagnosis of Diseases
- Context-specific stress causes compartmentalized SARM1 activation and local degeneration in cortical neurons
- cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice
- Genome sequence analyses identify novel risk loci for multiple system atrophy
- Knowns and unknowns of TiLV-associated neuronal disease
- The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond
- Pathogenesis and immunopathology of paraneoplastic disorders
- Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
- The complement system in neurodegenerative diseases
- Microglial AT1R conditional knockout ameliorates hypoperfusive cognitive impairment by reducing microglial inflammatory responses
- PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
- Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System
- Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions
- Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
- The proteomic landscape of microglia in health and disease
- Nanopore-based DNA long-read sequencing analysis of the aged human brain
- Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
- Dissecting Parkinson's disease with long-read RNA-sequencing
- GFAP-isoforms in the nervous system: Understanding the need for diversity
- Protective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects
- Changing landscape in the field of paraneoplastic neurology: Personal perspectives over a 35-year career
- Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity
- Functional myelin in cognition and neurodevelopmental disorders
- Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
- A tough bioadhesive hydrogel supports sutureless sealing of the dural membrane in porcine and ex vivo human tissue
- Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system
- Senescence: A DNA damage response and its role in aging and Neurodegenerative Diseases
- Lineage Analysis and Birthdating of Drosophila Central Complex Lineages
- Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets
- Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis
- Regulated cell death and its role in Alzheimer's disease and amyotrophic lateral sclerosis
Evidence Blueprint
Microglial inflammation in genome instability: A neurodegenerative perspective
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Microglial inflammation in genome instability: A neurodegenerative perspective
🌐 365 Days
VR Related Evidence Matrix
- Genomic stress and impaired DNA repair in Alzheimer disease
- Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders
- The Contribution of Microglia and Brain-Infiltrating Macrophages to the Pathogenesis of Neuroinflammatory and Neurodegenerative Diseases during TMEV Infection of the Central Nervous System
- Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases
- Interaction between central nervous system and immune system after ischemic stroke and its therapeutic significance of traditional Chinese medicine
- Border-associated macrophages in the central nervous system
- FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
- Glial Cell Development and Function in the Zebrafish Central Nervous System
- Genetic determinants of micronucleus formation in vivo
- Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome
- Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
- Aflatoxin B1 Exacerbates Genomic Instability and Apoptosis in the BTBR Autism Mouse Model via Dysregulating DNA Repair Pathway
- New Views of the DNA Repair Protein Ataxia-Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases
- cGAS-STING drives ageing-related inflammation and neurodegeneration
- The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap
- Variations in 3D genome structure between homologous chromosomes and in stimulus responses
- Variations in 3D genome structure between homologous chromosomes and in stimulus responses
- Research paper: Crosstalk of highly purified microglia and astrocytes in the frame of Toll-like receptor (TLR)2/1 activation
- Cross-regulation between the immune system and the extracellular matrix during lung pathology
- Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model
- DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation
- Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies
- A novel role for astrocytic fragmented mitochondria in regulating morphine addiction
- Current methods for the microglia isolation: Overview and comparative analysis of approaches
- Innate immune activation in neurodegenerative diseases
- TrkB-dependent regulation of molecular signaling across septal cell types
- The major histocompatibility complex participates in Parkinson's disease
- The Impact of Microglia on Neurodevelopment and Brain Function in Autism
- Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies
- Inflammation in pathogenesis of chronic pain: Foe and friend
- TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk
- Microglia in neuroimmunopharmacology and drug addiction
- The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
- The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
- Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples
- New Insights into the Roles of p53 in Central Nervous System Diseases
- Optical genome mapping identifies a novel pediatric embryonal tumor with a ZNF532::NUTM1 fusion
- Current status of DNA methylation profiling in neuro-oncology as a diagnostic support tool: A review
- Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation
- Hypoxia inducible factor-1a regulates microglial innate immune memory and the pathology of Parkinson's disease
- Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
- Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
- Building CRISPR Gene Therapies for the Central Nervous System: A Review
- Postnatal epigenome-mediated aging control and global trends
- Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
- Genes in Axonal Regeneration
- Boundaries and integration between microbiota, the nervous system, and immunity
- Biological agents and the aging brain: glial inflammation and neurotoxic signaling
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- The enteric nervous system relays psychological stress to intestinal inflammation
- Multiomic spatial landscape of innate immune cells at human central nervous system borders
- Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease
- The systemic immune response in Parkinson's disease: focus on the peripheral immune component
- How myeloid cells shape experimental autoimmune encephalomyelitis: at the crossroads of outside-in immunity
- Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19
- Implication of system xc- in neuroinflammation during the onset and maintenance of neuropathic pain
- Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century
- Expanding horizons of tandem repeats in biology and medicine: Why 'genomic dark matter' matters
- Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies
- Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Alterations of Gastrointestinal Microbe Composition in Various Human Diseases and Its Significance in the Early Diagnosis of Diseases