Absence of Directional Sensitivity of Dynamic Cerebral Autoregulation in Acute Ischemic Stroke

12/09/2026

AI Summary

Directional sensitivity to MAP changes was present in controls but absent in acute ischaemic stroke patients after correction for end-tidal CO2.
Autoregulatory index measures showed impaired responses to both increases and decreases in MAP in affected and unaffected hemispheres compared with controls.
Findings imply dysfunction of vasoconstriction and vasodilation, potentially mediated by endothelial injury, vascular smooth muscle impairment, or Piezo mechanosensitive ion channel dysfunction.

TL;DR (AI Generated)

Dynamic cerebral autoregulation (dCA) is impaired in acute ischemic stroke (AIS) and this dysfunction has been associated with worse clinical outcomes.

We hypothesize that directional sensitivity is impaired following AIS and may contribute to the altered dCA seen in stroke.

For example, median autoregulatory index measures during increases (ARI+D) and decreases (ARI-D) in MAP were impaired following AIS (affected hemisphere: ARI+D 5.3 [IQR: 3.7, 6.3], ARI-D 4.4 [IQR: 3.8, 6.1], p=0.088; unaffected hemisphere: ARI+D 5.3 [IQR: 4.1, 6.1], ARI-D 4.2 [3.5, 6.1], p=0.174) compared to control (right hemisphere: ARI+D 6.6 [IQR: 5.3, 8.2], ARI-D 5.7 [IQR: 3.6, 5.4], p=0.007; left hemisphere: ARI+D 6.4 [IQR: 5.0, 8.2], ARI-D 5.5 [4.6, 6.9], p=0.026).

Basic summary

Am J Physiol Heart Circ Physiol. 2026 Sep 11. doi: 10.1152/ajpheart.00546.2026. Online ahead of print.

ABSTRACT

Dynamic cerebral autoregulation (dCA) is impaired in acute ischemic stroke (AIS) and this dysfunction has been associated with worse clinical outcomes. It has been demonstrated that the cerebral circulation responds differently to increases and decreases of mean arterial blood pressure (MAP). This phenomenon is known as directional sensitivity and has been characterized in healthy participants but is yet to be described in AIS. We hypothesize that directional sensitivity is impaired following AIS and may contribute to the altered dCA seen in stroke. Retrospective analysis of transcranial Doppler ultrasound recordings of middle cerebral artery blood velocity were analyzed in 34 patients with AIS (23 male) and 34 age-matched healthy controls (22 male). Following correction for differences in EtCO2, directional sensitivity was observed in controls, but absent in patients with AIS. For example, median autoregulatory index measures during increases (ARI_+D) and decreases (ARI_-D) in MAP were impaired following AIS (affected hemisphere: ARI_+D 5.3 [IQR: 3.7, 6.3], ARI_-D 4.4 [IQR: 3.8, 6.1], p=0.088; unaffected hemisphere: ARI_+D 5.3 [IQR: 4.1, 6.1], ARI_-D 4.2 [3.5, 6.1], p=0.174) compared to control (right hemisphere: ARI_+D 6.6 [IQR: 5.3, 8.2], ARI_-D 5.7 [IQR: 3.6, 5.4], p=0.007; left hemisphere: ARI_+D 6.4 [IQR: 5.0, 8.2], ARI_-D 5.5 [4.6, 6.9], p=0.026). As AIS was associated with impaired responses to increases and decreases in MAP, dysfunction of vasoconstriction and vasodilation are suspected. These changes may relate to the effect of AIS on the endothelium, vascular smooth muscle, or piezo mechanosensitive ion-channels.

PMID:42728213 | DOI:10.1152/ajpheart.00546.2026

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