Category: Bipolar Disorder

Neural Markers of Reward Valuation and Impulsive Decision-Making in Mania Risk

JAMA Psychiatry. 2026 Aug 19. doi: 10.1001/jamapsychiatry.2026.2510. Online ahead of print.ABSTRACTIMPORTANCE: Mania or hypomania, the pathognomonic feature of bipolar disorder (BD), is associated with reward...

Bipolar Disorder RAISR4D

Alkali-Assisted Stitching Growth of Centimeter-Scale PtSe2 Films from Unidirectionally Aligned Millimeter-Scale Ribbons

Nano Lett. 2026 Aug 19;26(32):10834-10842. doi: 10.1021/acs.nanolett.6c02618.ABSTRACTSeamless stitching of aligned two-dimensional (2D) domains offers a promising route toward scalable single-crystal 2D materials but remains challenging...

Bipolar Disorder RAISR4D

The Association Between Lithium Use and Physical Comorbidities Across Age Groups: A Cross-Sectional Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

Acta Psychiatr Scand. 2026 Aug 19. doi: 10.1111/acps.70134. Online ahead of print.ABSTRACTINTRODUCTIONS: Lithium remains the first-line maintenance treatment for bipolar disorder (BD), yet its safety...

Bipolar Disorder RAISR4D

Pulsed Field Ablation Therapy Parameters: Enhancing Lesion Depth While Reducing Musculoskeletal Stimulation and Thermal Response in an Irrigated Tip Catheter: A Comprehensive Study Using In Silico, In Vitro, and In Vivo Models

Circ Arrhythm Electrophysiol. 2026 Aug 19:e014955. doi: 10.1161/CIRCEP.126.014955. Online ahead of print.ABSTRACTBACKGROUND: Pulsed field ablation therapies need to be optimized to maximize lesion depth while...

Bipolar Disorder RAISR4D

Computational identification of Allium sativum phytochemicals with predicted binding to the dopamine D2 receptor relevant to bipolar disorder

J Recept Signal Transduct Res. 2026 Aug 19:1-12. doi: 10.1080/10799893.2026.2718727. Online ahead of print.ABSTRACTBipolar disorder is a mental illness that causes people to have periods...

Bipolar Disorder RAISR4D

The complex relationship between endocrine and psychiatric disorders: an epidemiological study of risk estimates

Med Pharm Rep. 2026 Jul;99(3):174-183. doi: 10.15386/mpr-2968. Epub 2026 Jul 30.ABSTRACTBACKGROUNDS AND AIMS: Psychiatric comorbidities are frequently observed in patients with endocrine disorders, yet in...

Bipolar Disorder RAISR4D

17/08/2026

Ascl1 Represses Müller Glial and Promotes Rod Photoreceptor Fate Through Repressing Notch Signaling in Late Retinal Progenitor Cells

Invest Ophthalmol Vis Sci. 2026 Aug 3;67(10):41. doi: 10.1167/iovs.67.10.41.ABSTRACTPURPOSE: Ascl1 is a transcription factor (TF) that plays key roles in regulating retinal development. Recent studies...

Bipolar Disorder RAISR4D

17/08/2026

Early metabolic and gut microbiota alterations during antipsychotic-lithium treatment in acute bipolar mania: A prospective follow-up study

J Affect Disord. 2026 Aug 16:122389. doi: 10.1016/j.jad.2026.122389. Online ahead of print.ABSTRACTOBJECTIVE: To investigate early metabolic changes, gut microbiota alterations, and the correlations between key...

Bipolar Disorder RAISR4D

14/08/2026

IL-1beta pathway-dependent regulation of glutamate receptor activity by gut microbiota in bipolar depression

J Zhejiang Univ Sci B. 2026 Jul 1;27(8):888-905. doi: 10.1631/jzus.B2500219.ABSTRACTOBJECTIVES: Neuroinflammation may disrupt neurotransmitter signaling. This study investigated whether gut microbiota-induced neuroinflammation can regulate glutamate...

Bipolar Disorder RAISR4D

12/08/2026

Lineage Tracing Reveals atoh7-Positive and Negative Retinal Ganglion Cell Populations in the Zebrafish Retina

Invest Ophthalmol Vis Sci. 2026 Aug 3;67(10):31. doi: 10.1167/iovs.67.10.31.ABSTRACTPURPOSE: Atoh7 is a transiently expressed developmental transcription factor that contributes to the generation of all seven...

Bipolar Disorder RAISR4D

12/08/2026

Evaluating Extraction of Magnesium and Lithium Compounds from Seawater Using Byproducts of Demonstration-Scale Bipolar Membrane Electrodialysis

ChemSusChem. 2026 Aug 27;19(16):e70948. doi: 10.1002/cssc.70948.ABSTRACTSeawater is an abundant source of critical minerals, but low concentrations make mining uneconomical. Coupling seawater mining with other ocean-based...

Bipolar Disorder RAISR4D

12/08/2026

What are the clinical implications of mixed features in major depressive disorder? A VAST-D report

J Psychopharmacol. 2026 Aug 12:2698811261474121. doi: 10.1177/02698811261474121. Online ahead of print.ABSTRACTBACKGROUND: Mixed manic/hypomanic symptoms commonly occur in major depressive disorder (MDD), yet their prognostic and...

Bipolar Disorder RAISR4D

Adaptive Functioning in Clients With Intellectual Disabilities or Borderline Intellectual Functioning and Psychiatric Comorbidity

J Appl Res Intellect Disabil. 2026 Jul;39(4):e70292. doi: 10.1111/jar.70292.ABSTRACTBACKGROUND: Assessment of adaptive functioning is part of the classification of intellectual disability and borderline intellectual functioning...

Bipolar Disorder RAISR4D

Intoxicated with Madness: Exploring the Psychology of Intoxication in Uncovering the Experimental Roots of the Kraepelinian Dichotomy

Transcult Psychiatry. 2026 Aug 11:13634615261471986. doi: 10.1177/13634615261471986. Online ahead of print.ABSTRACTScholarship surrounding the Kraepelinian dichotomy of dementia praecox and manic-depressive insanity has overwhelmingly approached Kraepelin's...

Bipolar Disorder RAISR4D

Prescription Trends for Bipolar Disorder With and Without Comorbid Substance Use and Anxiety Disorders: A Global Bipolar Cohort Collaborative Study

Bipolar Disord. 2026 Sep;28(6):e70167. doi: 10.1111/bdi.70167.ABSTRACTOBJECTIVES: To investigate pharmacological treatment patterns in individuals with bipolar disorder (BD) with and without comorbid substance use disorder (SUD)...

Bipolar Disorder RAISR4D

Quality-of-life and self-perceived inequity in people with severe mental illness: the SOFIA pilot study

Scand J Prim Health Care. 2026 Dec;44(1):2697923. doi: 10.1080/02813432.2026.2697923. Epub 2026 Aug 11.ABSTRACTBACKGROUND: Living with severe mental illness (SMI) adversely affects quality of life (QoL)....

Bipolar Disorder RAISR4D

Multimodal classification of mood disorders using structural MRI and polygenic risk scores: a machine learning ablation study in UK Biobank

Front Psychiatry. 2026 Jul 27;17:1883424. doi: 10.3389/fpsyt.2026.1883424. eCollection 2026.ABSTRACTOBJECTIVE: Mood disorder classification from neuroimaging alone remains limited by single-modality constraints and population-level heterogeneity. This study...

Bipolar Disorder RAISR4D

The Relation Between Perceived Social Support, Treatment Adherence and Recovery Among Individuals Diagnosed With Bipolar Disorder

Bipolar Disord. 2026 Sep;28(6):e70170. doi: 10.1111/bdi.70170.ABSTRACTINTRODUCTION: This cross-sectional descriptive study aims to examine the relationship between perceived social support, treatment adherence and recovery in individuals...

Bipolar Disorder RAISR4D

Unplanned health service utilisation among people living with cancer and mental health conditions: A retrospective matched case-comparison study in Australia

Aust N Z J Psychiatry. 2026 Aug 10:48674261470996. doi: 10.1177/00048674261470996. Online ahead of print.ABSTRACTBACKGROUND: Mental health conditions are associated with inequities across the cancer pathway,...

Bipolar Disorder RAISR4D

Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients

Eur Child Adolesc Psychiatry. 2026 Aug 10. doi: 10.1007/s00787-026-03123-2. Online ahead of print.ABSTRACTThe role of genetic factors shaping liability for psychosis remains unclear. Youth with...

Bipolar Disorder RAISR4D

Association of dopamine transporter gene DAT1 40-bp 3′ UTR VNTR polymorphism (rs28363170) with Psychiatric disorders susceptibility: A study from the Pakistani population

Mol Biol Rep. 2026 Aug 10;53(1):1377. doi: 10.1007/s11033-026-12392-8.ABSTRACTOBJECTIVE: The dopamine transporter gene (DAT1) is a critical component of the dopaminergic system and has been consistently...

Bipolar Disorder RAISR4D

Seroprevalence Study of Toxoplasma gondii Infection in Psychiatric and Neurological Disorders

Ann Afr Med. 2026 Aug 10. doi: 10.4103/aam.aam_76_26. Online ahead of print.ABSTRACTINTRODUCTION: Toxoplasma gondii infects one-third of the global human population and invades and chronically...

Bipolar Disorder RAISR4D

Differential contributions of β-tubulin isotypes to acentrosomal oocyte meiosis in C. elegans

J Cell Biol. 2026 Oct 5;225(10):e202511199. doi: 10.1083/jcb.202511199. Epub 2026 Aug 10.ABSTRACTOocyte meiotic spindles must achieve bipolarity and segregate chromosomes in the absence of centrosomes....

Bipolar Disorder RAISR4D

An Open-Label, Randomized, Active Controlled Trial Evaluating Sublingual Dexmedetomidine for Moderate to Severe Agitation in Inpatients With Schizophrenia or Bipolar Disorder

J Clin Psychopharmacol. 2026 Aug 10. doi: 10.1097/JCP.0000000000002232. Online ahead of print.ABSTRACTPURPOSE: Agitation can occur in patients with schizophrenia, schizoaffective disorder, and bipolar disorder. This...

Bipolar Disorder RAISR4D

Comparative Effectiveness of Pharmacogenomics for Treatment of Depression

J Clin Psychopharmacol. 2026 Aug 10. doi: 10.1097/JCP.0000000000002175. Online ahead of print.ABSTRACTPURPOSE/BACKGROUND: Pharmacogenomics (PGx), or the use of genetic information to assess drug-gene interactions, is...

Bipolar Disorder RAISR4D

Same-Day Discharge After GreenLight Laser Photoselective Vaporization of the Prostate in Patients With Moderate to Severe Lower Urinary Tract Symptoms

Cureus. 2026 Jul 10;18(7):e112408. doi: 10.7759/cureus.112408. eCollection 2026 Jul.ABSTRACTThe most common cause of severe lower urinary tract symptoms (LUTS) in men over 50 is benign...

Bipolar Disorder RAISR4D

Actual status of visitor and telephone restrictions for Japanese psychiatric inpatients: A retrospective observational study

PCN Rep. 2026 Aug 7;5(3):e70382. doi: 10.1002/pcn5.70382. eCollection 2026 Sep.ABSTRACTAIM: To clarify the status of visitor and telephone restrictions and the factors associated with these...

Bipolar Disorder RAISR4D

DNA methylation in bipolar disorder: mechanistic insights and translational challenges

Front Pharmacol. 2026 Jul 24;17:1871913. doi: 10.3389/fphar.2026.1871913. eCollection 2026.ABSTRACTBipolar disorder (BD) is a severe and recurrent psychiatric disorder characterized by alternating manic, hypomanic, and depressive...

Bipolar Disorder RAISR4D

When Patients Take Control: Prevalence, Motivations, and Clinical Correlates of Self-Initiated Psychiatric Medication Changes

Med Decis Making. 2026 Aug 7:272989X261464576. doi: 10.1177/0272989X261464576. Online ahead of print.ABSTRACTPURPOSE: To examine the prevalence and patterns of mental health patients' consideration and engagement...

Bipolar Disorder RAISR4D

Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites

Bipolar Disord. 2026 Sep;28(6):e70166. doi: 10.1111/bdi.70166.ABSTRACTBACKGROUND: Older adults with bipolar disorder (BD) are at high risk for severe mood symptoms, cognitive difficulties, and early mortality;...

Bipolar Disorder RAISR4D

07/08/2026

Arcuate fasciculus cortico-cortical and axono-cortical evoked potentials with post-resection excitability changes in perisylvian glioma

Clin Neurophysiol Pract. 2026 Jul 21;11:629-641. doi: 10.1016/j.cnp.2026.07.013. eCollection 2026.ABSTRACTOBJECTIVE: To evaluate the feasibility and clinical utility of arcuate fasciculus cortico-cortical evoked potentials (AF-CCEP) and...

Bipolar Disorder RAISR4D

Sensor Design for Ankle Resiliency Training

Mil Med. 2026 Aug 1;191(Supplement_1):621-630. doi: 10.1093/milmed/usag198.ABSTRACTINTRODUCTION: Lateral ankle sprains (LASs) are among the most common musculoskeletal injuries and are a leading cause of limited...

Bipolar Disorder RAISR4D

Severe Lithium Toxicity Following Concurrent Lithium and Nabumetone Use in a Patient With Bipolar I Disorder: A Case Report

Cureus. 2026 Jul 6;18(7):e112142. doi: 10.7759/cureus.112142. eCollection 2026 Jul.ABSTRACTLithium remains a cornerstone in the treatment of bipolar I disorder because of its well-established efficacy in...

Bipolar Disorder RAISR4D

Unravelling the role of alanine in mental disorders: a Mendelian randomisation study

J Nutr Sci. 2026 Jul 24;15:e65. doi: 10.1017/jns.2026.10128. eCollection 2026.ABSTRACTAlanine, commonly found in meaty foods and popular as a sports supplement, has interactions with neurotransmitters...

Bipolar Disorder RAISR4D

Editorial: Treatment resistant depression: epidemiology, clinic, burden and treatment, volume II

Front Psychiatry. 2026 Jul 22;17:1935707. doi: 10.3389/fpsyt.2026.1935707. eCollection 2026.NO ABSTRACTPMID:42558498 | PMC:PMC13437537 | DOI:10.3389/fpsyt.2026.1935707

Bipolar Disorder RAISR4D

Diagnostic delays and suicidal thoughts and behaviors among young adults with a history of mood disorders

Front Psychiatry. 2026 Jul 22;17:1894148. doi: 10.3389/fpsyt.2026.1894148. eCollection 2026.ABSTRACTINTRODUCTION: Suicidal thoughts and behaviors (STBs) are prevalent among young adults with mood disorders. This study examined...

Bipolar Disorder RAISR4D

A 6-week ketogenic diet in treatment-resistant depression: a prospective single-arm feasibility pilot trial

Front Nutr. 2026 Jul 22;13:1870412. doi: 10.3389/fnut.2026.1870412. eCollection 2026.ABSTRACTBACKGROUND: Prior evidence for the ketogenic diet (KD) interventions in treatment-resistant depression (TRD) was very limited when...

Bipolar Disorder RAISR4D

Prevalence, symptom architecture, and clinical correlates of depressive and anxiety symptoms in bipolar disorder: A large-scale community-based study

J Affect Disord. 2026 Aug 5:122357. doi: 10.1016/j.jad.2026.122357. Online ahead of print.ABSTRACTBACKGROUND: Depressive and anxiety symptoms frequently persist during stable phases of bipolar disorder (BD),...

Bipolar Disorder RAISR4D

Effect of cementless femoral stem design on fracture pattern and reoperation rates after periprosthetic femoral fractures: A retrospective multicenter cohort study

Orthop Traumatol Surg Res. 2026 Aug 5:104824. doi: 10.1016/j.otsr.2026.104824. Online ahead of print.ABSTRACTINTRODUCTION: Periprosthetic femoral fracture (PPFx) is a serious complication of total hip arthroplasty...

Bipolar Disorder RAISR4D

Age-Stratified Patterns of Suicide Methods in Bipolar Disorder: A Nationwide Cohort Study

Acta Psychiatr Scand. 2026 Aug 5. doi: 10.1111/acps.70132. Online ahead of print.ABSTRACTOBJECTIVES: Age-stratified suicide methods in bipolar disorder remain underexplored. This study compared method selection...

Bipolar Disorder RAISR4D

Reduced rapid eye movement sleep proportion is associated with anxiety and depressive symptoms in newly diagnosed epilepsy

Epilepsia. 2026 Aug 5. doi: 10.1002/epi.70413. Online ahead of print.ABSTRACTOBJECTIVE: This study was undertaken to examine the associations between rapid eye movement (REM) sleep proportion,...

Bipolar Disorder RAISR4D

Hysteroscopic resection of a submucosal fibroid: hints and tips for a successful procedure

J Obstet Gynaecol. 2026 Dec;46(1):2710389. doi: 10.1080/01443615.2026.2710389. Epub 2026 Aug 4.ABSTRACTThe authors present a case of a successful two-stage hysteroscopic resection of a submucosal fibroid...

Bipolar Disorder RAISR4D

The data and metadata repository of the Québec Mental Health Alliance

Sante Ment Que. 2026 Spring-Summer;51(2):205-232.ABSTRACTObjectives In the era of artificial intelligence, our understanding of mental health challenges depends heavily on our ability to generate and...

Bipolar Disorder RAISR4D

Autism-specific spliceosomal transcriptomic signatures in prefrontal cortex contrasted with bipolar disorder

Trends Psychiatry Psychother. 2026 Aug 4. doi: 10.47626/2237-6089-2026-1336. Online ahead of print.ABSTRACTOBJECTIVE: Understanding the molecular mechanisms of autism spectrum disorder (ASD) and its psychiatric comorbidities,...

Bipolar Disorder RAISR4D

Cement Use in Bipolar Hemiarthroplasty and Its Association With Cancer Risk

J Korean Med Sci. 2026 Aug 3;41(30):e196. doi: 10.3346/jkms.2026.41.e196.ABSTRACTBACKGROUND: Previous studies have been unable to confirm a direct relationship between polymethylmethacrylate use and cancer risk...

Bipolar Disorder RAISR4D

The Toll-Like Receptor Signalling Pathway Is Altered in iPSC-Derived Cortical Networks From People With Bipolar Disorder

Bipolar Disord. 2026 Aug;28(5):e70169. doi: 10.1111/bdi.70169.ABSTRACTBACKGROUND: Induced pluripotent stem cell (iPSC)-derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as...

Bipolar Disorder RAISR4D

The Effect of Mindfulness-Based Psychoeducation Program on Mindfulness, Self-Compassion, and Forgiveness Tendencies of Patients with Bipolar Disorder: A Randomized Controlled Trial

Clin Nurs Res. 2026 Aug 4:10547738261466378. doi: 10.1177/10547738261466378. Online ahead of print.ABSTRACTThis study examined the effects of a mindfulness-based psychoeducation program on mindfulness, self-compassion, and...

Bipolar Disorder RAISR4D

Association between the Blood-Inflammatory Index with Depression and Anxiety in a Large Population

Iran J Public Health. 2025 Dec;54(12):2745-2753. doi: 10.18502/ijph.v54i12.20845.ABSTRACTBACKGROUND: Inflammatory indices have been linked to mood disorders. We aimed to examine whether these inflammatory indices are...

Bipolar Disorder RAISR4D

Proof of concept for a hypothesis that rapid cycling in a circular form of bipolar disorder is a pathological response to normal lunar cycles in sleep

Mol Psychiatry. 2026 Aug 3. doi: 10.1038/s41380-026-03799-7. Online ahead of print.ABSTRACTBased on several lines of evidence, we hypothesize that rapid cycling in a circular, lunar-synchronized...

Bipolar Disorder RAISR4D

Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics

Mol Psychiatry. 2026 Aug 4. doi: 10.1038/s41380-026-03736-8. Online ahead of print.ABSTRACTMood disorders are highly prevalent in society, often disabling, and can lead to a reduced...

Bipolar Disorder RAISR4D

Beyond androgen deprivation therapy: Next-generation hormonal therapies and emerging combination approaches in advanced prostate cancer

Urol Oncol. 2026 Aug 3:S1078-1439(26)00599-5. doi: 10.1016/j.urolonc.2026.07.014. Online ahead of print.ABSTRACTMultiple phase 3 studies have shown that early use of androgen receptor (AR) pathway inhibitors...

Bipolar Disorder RAISR4D

In memoriam Jules Angst, MD

Int J Bipolar Disord. 2026 Aug 3;14(1):29. doi: 10.1186/s40345-026-00433-x.ABSTRACTThis in memoriam honours Professor Jules Angst, MD, and reflects on his major contributions to mood disorder...

Bipolar Disorder RAISR4D

Sedentary Behavior and Physical Activity in Individuals With Bipolar Disorder: An Evidence Synthesis and Position Statement From the ISBD Nutrition and Exercise Task Force (NExT)

Bipolar Disord. 2026 Aug;28(5):e70164. doi: 10.1111/bdi.70164.ABSTRACTBACKGROUND: Higher time in sedentary behavior and insufficient physical activity are very common in bipolar disorder (BD). Whereas physical activity...

Bipolar Disorder RAISR4D

Advanced Manufacturing Routes for Electrodes and Cells in All-Solid-State Batteries: From Powder to Power

Small Methods. 2026 Aug 3:e70922. doi: 10.1002/smtd.70922. Online ahead of print.ABSTRACTAll-solid-state batteries (ASSBs) represent promising next-generation energy storage systems with superior safety and energy density...

Bipolar Disorder RAISR4D

Research progress of bipolar membrane interfacial layer catalysts: classification and performance optimization strategies

Chem Commun (Camb). 2026 Aug 3. doi: 10.1039/d6cc02691e. Online ahead of print.ABSTRACTBipolar membranes (BPMs), owing to their unique structure enabling efficient water dissociation and acid-base...

Bipolar Disorder RAISR4D

Clarifying age filtering in a TriNetX-based study on pediatric antidepressant use and treatment-emergent mania

J Psychopharmacol. 2026 Aug 3:2698811261473407. doi: 10.1177/02698811261473407. Online ahead of print.NO ABSTRACTPMID:42544422 | DOI:10.1177/02698811261473407

Bipolar Disorder RAISR4D

Cognitive remediation in people with bipolar disorder and cognitive dysfunction: a systematic review

J Psychiatry Neurosci. 2026 Jan 1;51:1-14. doi: 10.1139/jpn-2025-0229.ABSTRACTBACKGROUND: Cognitive impairment is a frequent feature of bipolar disorder (BD), often persisting during euthymic phases and affecting...

Bipolar Disorder RAISR4D

Hypomanic symptoms and first manic episode during ketogenic diet treatment in a patient taking venlafaxine: a case report with longitudinal glucose-ketone index and clinical monitoring

Front Nutr. 2026 Jul 16;13:1873930. doi: 10.3389/fnut.2026.1873930. eCollection 2026.ABSTRACTBACKGROUND: The ketogenic diet (KD) is gaining increasing interest as a metabolic intervention for neuropsychiatric disorders, including...

Bipolar Disorder RAISR4D

Fragile self, mechanical world: mechanistic delusions and ego fragility in schizotypal-affective spectrum disorder-a CARE case report

Front Psychiatry. 2026 Jul 16;17:1896591. doi: 10.3389/fpsyt.2026.1896591. eCollection 2026.ABSTRACTCategorical nosological systems frequently fall short when confronted with patients whose presentations cross established diagnostic boundaries. We...

Bipolar Disorder RAISR4D