- CPAP adherence, defined as at least 4 h per night, was associated with reduced incident major depressive disorder in OSA patients (HR 0.83, p=0.04).
- Over a median 8.45-year follow-up, 20.7% developed MDD: 24.2% in non-adherent versus 19.2% in adherent patients.
- Association remained after adjustment for age, sex, BMI, socio-professional factors, insomnia complaint and baseline depressive symptoms; further studies warranted.
J Sleep Res. 2026 Sep 10:e70452. doi: 10.1111/jsr.70452. Online ahead of print.
ABSTRACT
Obstructive sleep apnoea (OSA) is associated with major depressive disorder (MDD). However, limited data exist regarding the impact of continuous positive airway pressure (CPAP) on MDD incidence. Data from the Pays de la Loire Cohort were linked to health administrative data to identify incident MDD, defined by antidepressant prescription or hospitalisation for MDD, in patients with no history of psychiatric disorders (depressive, bipolar, psychotic and anxiety disorders) who were prescribed CPAP. Patients with documented CPAP use of at least 4 h per night were compared to those with less than 4 h of use. Cox proportional hazards models were used. After a median follow-up of 8.45 years, 561 (20.7%) of 2712 patients developed MDD, including 200 (24.2%) in the non-adherent group (n = 827) and 361 (19.2%) in the adherent group (n = 1885). CPAP adherence was associated with a reduced risk of MDD, even after adjusting for age, sex, BMI, socio-professional factors, insomnia complaint and baseline depressive symptoms (HR = 0.83 [0.70-0.99], p = 0.04). In a population free of prior all psychiatric disorders and treated for OSA with CPAP, adherence to therapy is associated with a lower incidence of MDD. Further studies are warranted to clarify whether non-adherent patients display vulnerability factors-such as insomnia-that may increase their risk of developing MDD.
PMID:42722435 | DOI:10.1111/jsr.70452
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
