AI Summary
- Antipsychotic non-adherence, driven partly by stigma, worsens outcomes in severe mental illness.
- Sustained antipsychotic treatment reduces mortality, cardiovascular risk, suicide, inflammation and cognitive decline, and improves quality of life.
- Reframing antipsychotics as essential medical care may reduce stigma and improve engagement between patients and clinicians.
Br J Psychiatry. 2026 Sep 14:1-3. doi: 10.1192/bjp.2026.10786. Online ahead of print.
ABSTRACT
Antipsychotic non-adherence, driven partly by stigma, worsens outcomes in severe mental illness. Beyond ameliorating psychosis, evidence shows sustained antipsychotic treatment reduces mortality, cardiovascular risk, suicide, inflammation and cognitive decline, while improving quality of life. Reframing antipsychotics as essential medical care may reduce stigma and improve engagement with patients and clinicians.
PMID:42734079 | DOI:10.1192/bjp.2026.10786
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