- Subjective cognitive complaints are multidimensional, comprising affective and iatrogenic components as well as degeneration-related components.
- Baseline objective performance did not predict incident SCC, whereas benzodiazepine use and depressive symptoms did, indicating affective and medication influences.
- SCC predicted incident cognitive impairment, so in resource-limited settings they can enrich risk stratification and prompt medication and mood review.
J Alzheimers Dis. 2026 Oct 9:13872877261497234. doi: 10.1177/13872877261497234. Online ahead of print.
ABSTRACT
Subjective cognitive complaints (SCC) are shifting from a quasi-diagnostic marker to a multidimensional clinical signal. Leniz et al. use the semi-rural Chilean MAUCO cohort to extend this debate beyond Western-dominated settings. They show a subjective-objective discrepancy: baseline objective performance did not predict incident SCC, whereas benzodiazepine use, and depressive symptoms did, highlighting affective and iatrogenic influences. Yet SCC predicted incident cognitive impairment. We argue that these findings are better interpreted by a model of SCC with at least two-components: affective/iatrogenic and degeneration-related components. In resource-limited contexts, SCC may aid risk-enrichment while prompting medication and mood review.
PMID:42852840 | DOI:10.1177/13872877261497234
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
