Dementia – Page 4 – Psychiatry AI: Real-Time AI Scoping Review

Dementia RAISR4D

13/08/2026

Psychiatric-onset prodromal dementia with lewy bodies: a comparative analysis of two cases

Fukushima J Med Sci. 2026 Aug 13. doi: 10.5387/fms.26-00018. Online ahead of print.ABSTRACTPsychiatric-onset DLB refers to a prodromal presentation of DLB in which late-life psychiatric...

Dementia RAISR4D

12/08/2026

Sex and gender specific considerations on frailty: what have we learned?

Eur J Intern Med. 2026 Aug 12:107130. doi: 10.1016/j.ejim.2026.107130. Online ahead of print.ABSTRACTAging entails a progressive impairment of functions and, ultimately, leads to increased susceptibility...

Dementia RAISR4D

12/08/2026

Evaluation of genetic instability in patients with amyotrophic lateral sclerosis

Mutat Res Genet Toxicol Environ Mutagen. 2026 Jul;913:503953. doi: 10.1016/j.mrgentox.2026.503953. Epub 2026 Jul 30.ABSTRACTGenetic instability has been reported in several neurodegenerative diseases, such as Alzheimer's...

Dementia RAISR4D

12/08/2026

‘Doing it together?’ A dyadic qualitative study of perceptions, facilitators, barriers and expectations for physical activity in dementia

Age Ageing. 2026 Aug 3;55(8):afag235. doi: 10.1093/ageing/afag235.ABSTRACTINTRODUCTION: Persons with dementia and their caregivers are more physically inactive than cognitively healthy peers or non-caregivers, yet little...

Dementia RAISR4D

12/08/2026

GLP-1 receptor agonists, metabolic syndrome, and Alzheimer’s disease: Lessons and opportunities from the EVOKE trials

J Neuroendocrinol. 2026 Aug;38(8):e70246. doi: 10.1111/jne.70246.ABSTRACTMetabolic syndrome and Alzheimer's disease (AD) are increasingly recognised as interconnected, sharing vascular, metabolic and inflammatory pathways that accelerate brain...

Dementia RAISR4D

11/08/2026

Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults

Alzheimers Dement. 2026 Aug;22(8):e71743. doi: 10.1002/alz.71743.ABSTRACTINTRODUCTION: Subjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis...

Dementia RAISR4D

11/08/2026

Structural Heterogeneity of TDP-43 Fragments in Alzheimer’s Disease and Primary Age-Related Tauopathy by Artificial Intelligence (AI)-Based 3D Segmentation

Neuropathol Appl Neurobiol. 2026 Aug;52(4):e70096. doi: 10.1111/nan.70096.ABSTRACTTAR DNA-binding protein 43 (TDP-43) inclusions are defining pathological features of frontotemporal lobar degeneration (FTLD) but are also often...

Dementia RAISR4D

11/08/2026

Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial-oligodendrocyte responses

Alzheimers Dement. 2026 Aug;22(8):e71742. doi: 10.1002/alz.71742.ABSTRACTINTRODUCTION: Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs...

Dementia RAISR4D

11/08/2026

Multidimensional workplace stressors differentially impact cognitive trajectories

Alzheimers Dement. 2026 Aug;22(8):e71733. doi: 10.1002/alz.71733.ABSTRACTINTRODUCTION: Little research has assessed detailed occupational exposures in relation to the dementia exposome. We characterized patterns of multidimensional workplace...

Dementia RAISR4D

11/08/2026

Preserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization

Geroscience. 2026 Aug 10. doi: 10.1007/s11357-026-02467-6. Online ahead of print.ABSTRACTKnee osteoarthritis (KOA) is a leading cause of late-life pain, mobility loss, and disability, and is...

Dementia RAISR4D

11/08/2026

The Amino Acid-Neurodegeneration Axis: Excitotoxicity and Oxidative Stress as Context-Dependent Amplifiers of Metabolic Dysfunction

Mol Neurobiol. 2026 Aug 10;63(1):827. doi: 10.1007/s12035-026-06121-2.ABSTRACTHomeostasis of amino acids is essential for the integrity of the CNS, and is maintained by a tightly regulated...

Dementia RAISR4D

11/08/2026

Advanced imaging of membrane contact sites

Nat Cell Biol. 2026 Aug;28(8):1612-1625. doi: 10.1038/s41556-026-02003-w. Epub 2026 Aug 7.ABSTRACTOrganelle membrane contact sites (MCSs) coordinate key cell activities and their alterations are associated with...

Dementia RAISR4D

11/08/2026

Menopause and neurological disorders: a roadmap for research

Nat Rev Neurol. 2026 Aug 10. doi: 10.1038/s41582-026-01244-5. Online ahead of print.ABSTRACTMenopause is under-recognized as a biological and sociocultural contributor to brain health, and scientific...

Dementia RAISR4D

11/08/2026

High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density

Commun Med (Lond). 2026 Aug 10;6(1):434. doi: 10.1038/s43856-026-01846-6.ABSTRACTBACKGROUND: Flickering visual stimulation can evoke neural oscillations, which can influence ongoing brain activity. Electrophysiological recordings of neural...

Dementia RAISR4D

11/08/2026

Liquid-liquid phase-separated tau colocalizes with and stabilizes Aβ oligomers

Commun Chem. 2026 Aug 10;9(1):273. doi: 10.1038/s42004-026-02165-6.ABSTRACTProtein aggregation is a hallmark of neurodegenerative diseases, where misfolded proteins accumulate into insoluble deposits. Emerging studies indicate that...

Dementia RAISR4D

10/08/2026

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER-TBI Observational Study

Ann Clin Transl Neurol. 2026 Aug 9. doi: 10.1002/acn3.70509. Online ahead of print.ABSTRACTOBJECTIVE: Reserve refers to the brain's ability to maintain function after an injury...

Dementia RAISR4D

10/08/2026

Comment on “Executive and General Cognitive Domain as a Relevant Factor of Specific Neuropsychiatric Symptoms in Alzheimer’s Disease”

Geriatr Gerontol Int. 2026 Aug;26(8):e70763. doi: 10.1111/ggi.70763.NO ABSTRACTPMID:42572118 | DOI:10.1111/ggi.70763

Dementia RAISR4D

10/08/2026

Replay Letter to: ‘Loneliness as an Interface Between Alzheimer’s Disease and Suicidal Behaviour: A Methodological Concern’

Psychogeriatrics. 2026 Sep;26(5):e70203. doi: 10.1111/psyg.70203.NO ABSTRACTPMID:42572115 | DOI:10.1111/psyg.70203

Dementia RAISR4D

10/08/2026

Association between glomerular filtration rate and comprehensive geriatric assessment parameters in older adults

Int Urol Nephrol. 2026 Aug 9. doi: 10.1007/s11255-026-05320-z. Online ahead of print.ABSTRACTBACKGROUND/AIM: This study aimed to investigate the association between estimated glomerular filtration rate (eGFR)...

Dementia RAISR4D

10/08/2026

Letter to the Editor “Therapeutic Time Window of Disease-Modifying Therapy for Early Alzheimer’s Disease in Japanese Individuals: Analysis Based on J-ADNI Study”

Geriatr Gerontol Int. 2026 Aug;26(8):e70784. doi: 10.1111/ggi.70784.NO ABSTRACTPMID:42572052 | DOI:10.1111/ggi.70784

Dementia RAISR4D

10/08/2026

Comparison of remimazolam and dexmedetomidine on perioperative hemodynamics, postoperative mood, cognition, and delirium in elderly stroke patients undergoing mechanical thrombectomy: a single-center prospective cohort study

Naunyn Schmiedebergs Arch Pharmacol. 2026 Aug 10. doi: 10.1007/s00210-026-05777-w. Online ahead of print.ABSTRACTOptimal sedation strategies for elderly patients with acute ischemic stroke (AIS) undergoing mechanical...

Dementia RAISR4D

10/08/2026

Extending geriatric care beyond traditional settings: lessons from a mobile assessment program

Isr J Health Policy Res. 2026 Aug 10;15(1):31. doi: 10.1186/s13584-026-00775-y.ABSTRACTBACKGROUND: As populations age, changing living conditions and declining self-advocacy often create barriers to essential care....

Dementia RAISR4D

10/08/2026

Associations of Adiposity With Cortical Atrophy and Network Dyssynchrony in Type 2 Diabetes: A Multimodal MRI Study

Diabetes Obes Metab. 2026 Aug 9. doi: 10.1111/dom.71187. Online ahead of print.ABSTRACTAIMS: While Type 2 diabetes mellitus (T2DM) is a known risk factor for cognitive...

Dementia RAISR4D

10/08/2026

A Novel Methodology for Temporal Analysis of Consumer Wearable Sleep Data: Feasibility and Application to Early Cognitive Impairment

Exp Neurobiol. 2026 Aug 10. doi: 10.5607/en26014. Online ahead of print.ABSTRACTWhile sleep disturbances are recognized as early markers of Alzheimer's disease (AD), the practical application...

Dementia RAISR4D

10/08/2026

Culturally adapted wearable mobile health intervention for physical activity and cognitive function in middle-aged Koreans: a pilot feasibility study

J Yeungnam Med Sci. 2026;43:53. doi: 10.12701/jyms.2026.43.53. Epub 2026 Aug 10.ABSTRACTBACKGROUND: Middle adulthood (45-64 years) represents a critical window for the primary prevention of cognitive...

Dementia RAISR4D

09/08/2026

Semantic fluency predicts survival of memory clinic patients

Alzheimers Res Ther. 2026 Aug 7;18(1):181. doi: 10.1186/s13195-026-02152-y.ABSTRACTBACKGROUND: Semantic fluency is commonly assessed in the diagnostic work-up of individuals with suspected cognitive impairment due to...

Dementia RAISR4D

09/08/2026

An ApoE-Associated Low-Inflammatory Microglial State Emerges After Inflammatory Challenge in Alzheimer’s Disease Mice

Neurosci Bull. 2026 Aug 8. doi: 10.1007/s12264-026-01693-4. Online ahead of print.ABSTRACTPatients with Alzheimer's disease (AD) frequently experience inflammatory insults; however, the mechanisms by which microglia...

Dementia RAISR4D

09/08/2026

Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression

Acta Neuropathol. 2026 Aug 8;152(1):17. doi: 10.1007/s00401-026-03065-8.ABSTRACTHistopathologic staging models of neuronal α-synuclein pathology (n-asyn) in Lewy body disease (LBD) seldom evaluate brain regions with direct...

Dementia RAISR4D

09/08/2026

Corrigendum to “Association of grip indicators with post-discharge recovery in geriatric and hip fracture inpatients” Exp. Gerontol. 214 (2026) 113014

Exp Gerontol. 2026 Aug 6:113266. doi: 10.1016/j.exger.2026.113266. Online ahead of print.NO ABSTRACTPMID:42570920 | DOI:10.1016/j.exger.2026.113266

Dementia RAISR4D

09/08/2026

Treatments for vascular depression in older adults: A systematic review

Int Psychogeriatr. 2026 Aug 8:100249. doi: 10.1016/j.inpsyc.2026.100249. Online ahead of print.ABSTRACTBACKGROUND: Vascular depression (VaD) is a subtype of late-life depression (LLD) associated with cerebrovascular disease,...

Dementia RAISR4D

09/08/2026

Rutin ameliorates perioperative neurocognitive disorders by inhibiting microglial HIF-1α/PKM2‑driven glycolysis

Brain Res Bull. 2026 Aug 8:112075. doi: 10.1016/j.brainresbull.2026.112075. Online ahead of print.ABSTRACTBACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in elderly patients, largely driven by...

Dementia RAISR4D

09/08/2026

Aerobic exercise improves cognition in sepsis-associated encephalopathy by enhancing glucose metabolism through astrocytic GLUT1

Exp Neurol. 2026 Aug 8:115956. doi: 10.1016/j.expneurol.2026.115956. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) is a common neurological complication of sepsis and a major cause of...

Dementia RAISR4D

09/08/2026

Transferrin receptor upregulation mediates homocysteine-induced cytotoxicity in cerebral endothelial cells

Brain Res. 2026 Aug 8:150486. doi: 10.1016/j.brainres.2026.150486. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is a recognized risk factor for cognitive impairment, including Alzheimer's disease, but the...

Dementia RAISR4D

09/08/2026

Dorsomedial thalamic nucleus-medial prefrontal cortex inputs modulated spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture

Brain Res. 2026 Aug 8:150488. doi: 10.1016/j.brainres.2026.150488. Online ahead of print.ABSTRACTBACKGROUND: Sepsis-associated encephalopathy (SAE) often leads to cognitive impairment and even life-threatening conditions. Its pathophysiology...

Dementia RAISR4D

09/08/2026

A Covered Benefit with an Untrusted On-Ramp: Why Medicare Principal Illness Navigation Still Is Not Reaching Patients

J Cancer Policy. 2026 Aug 8:100794. doi: 10.1016/j.jcpo.2026.100794. Online ahead of print.ABSTRACTPrincipal Illness Navigation (PIN) represents an important Medicare policy advance, but coverage has not...

Dementia RAISR4D

08/08/2026

Associations Between Smartwatch-Derived Measures and Cognitive Function: Findings From the Electronic Framingham Heart Study

J Am Heart Assoc. 2026 Aug 7:e049284. doi: 10.1161/JAHA.126.049284. Online ahead of print.ABSTRACTBACKGROUND: Daily heart rate (HR) and physical activity are biomarkers of cardiovascular disease....

Dementia RAISR4D

08/08/2026

Interactive Effects of Plasma Alzheimer Disease Biomarkers and White Matter Hyperintensities on Cognitive Decline and Clinical Progression in Nondemented Adults

J Am Heart Assoc. 2026 Aug 7:e050676. doi: 10.1161/JAHA.126.050676. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer disease pathology and cerebral small-vessel disease frequently coexist in older adults,...

Dementia RAISR4D

08/08/2026

Effects of Physical Activity on Brain White Matter Integrity Are Region-, Dose-, and Age-Dependent: Findings From the Population-Based Rhineland Study

Aging Cell. 2026 Aug;25(8):e70659. doi: 10.1111/acel.70659.ABSTRACTWhite matter integrity is a sensitive marker of cerebrovascular health and aging. Physical activity may promote white matter health, but...

Dementia RAISR4D

08/08/2026

Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults

Cogn Affect Behav Neurosci. 2026 Aug 7. doi: 10.3758/s13415-026-01482-6. Online ahead of print.ABSTRACTAlthough evidence suggests that psychosocial stress is a risk factor for cognitive decline...

Dementia RAISR4D

08/08/2026

ARG128-associated recognition of nobiletin by BACE1 revealed by triplicate molecular dynamics, MM-GBSA, and residue-level decomposition

Mol Divers. 2026 Aug 7. doi: 10.1007/s11030-026-11693-1. Online ahead of print.ABSTRACTAlzheimer's disease (AD) remains the leading cause of dementia worldwide, and beta-secretase 1 (BACE1) remains...

Dementia RAISR4D

08/08/2026

Corpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors

Geroscience. 2026 Aug 8. doi: 10.1007/s11357-026-02447-w. Online ahead of print.ABSTRACTDementia arises from multifactorial neurodegenerative processes, with growing evidence implicating blood-brain barrier dysfunction, neuroinflammation, and vascular...

Dementia RAISR4D

08/08/2026

Factors associated with hip fracture following a fall-associated hospitalization in older adults: a retrospective cohort study

Osteoporos Int. 2026 Aug 8. doi: 10.1007/s00198-026-08181-5. Online ahead of print.ABSTRACTAmong older adults hospitalized after a fall, receiving a DXA scan was associated with a...

Dementia RAISR4D

08/08/2026

Inside and outside the body space: a study on environmental knowledge, interoceptive and functional body representations in the prodromal stage of dementia

Neurol Sci. 2026 Aug 8;47(9):692. doi: 10.1007/s10072-026-09294-9.ABSTRACTBACKGROUND: There is increasing interest in identifying sensitive cognitive markers for the early detection of Alzheimer's disease (AD). Spatial...

Dementia RAISR4D

08/08/2026

Functional heterogeneity across structural MRI-based atrophy subtypes in Alzheimer’s disease

Int Psychogeriatr. 2026 Aug 7:100255. doi: 10.1016/j.inpsyc.2026.100255. Online ahead of print.ABSTRACTOBJECTIVES: This study explored whether distinct Alzheimer's disease (AD) structural atrophy subtypes exhibit divergent functional...

Dementia RAISR4D

08/08/2026

Patterns of ADL and IADL independence across MMSE score ranges in Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal dementia: A cross-sectional analysis of a memory-clinic cohort

Int Psychogeriatr. 2026 Aug 7:100250. doi: 10.1016/j.inpsyc.2026.100250. Online ahead of print.ABSTRACTBACKGROUND: Domain-level ADL and IADL independence across MMSE score ranges has been less well described...

Dementia RAISR4D

07/08/2026

Impact of Narrative Nursing and Cognitive Behavioral Rehabilitation on Cognitive Function and Anxiety in Patients With Alzheimer’s Disease

Geriatr Gerontol Int. 2026 Aug;26(8):e70719. doi: 10.1111/ggi.70719.ABSTRACTOBJECTIVE: Alzheimer's disease (AD) progressively impairs cognitive function and quality of life (QoL). Patients frequently experience anxiety, which may...

Dementia RAISR4D

07/08/2026

Mitochondrial alterations in pellagra-associated central chromatolysis: Comparison with ballooned achromatic neurons of other etiologies

J Neuropathol Exp Neurol. 2026 Aug 6:nlag058. doi: 10.1093/jnen/nlag058. Online ahead of print.ABSTRACTNeuronal central chromatolysis (CC) is the histopathological hallmark of pellagra encephalopathy, a neurological...

Dementia RAISR4D

07/08/2026

A phosphorylation‑independent monoclonal antibody improves detection of TDP‑43 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP‑43 encephalopathy neuropathological change

J Neuropathol Exp Neurol. 2026 Aug 6:nlag085. doi: 10.1093/jnen/nlag085. Online ahead of print.ABSTRACTTDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), amyotrophic lateral sclerosis...

Dementia RAISR4D

07/08/2026

Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington’s disease

Neurotherapeutics. 2026 Aug 5:e00970. doi: 10.1016/j.neurot.2026.e00970. Online ahead of print.ABSTRACTMutant C9orf72 has been extensively studied as a major genetic cause of amyotrophic lateral sclerosis and...

Dementia RAISR4D

07/08/2026

Age-Triggered Cognitive Testing of Late-career Physicians: Time to Reassess Current Practices

Am J Geriatr Psychiatry. 2026 Jul 10:S1064-7481(26)00453-7. doi: 10.1016/j.jagp.2026.07.001. Online ahead of print.ABSTRACTPhysicians and health care organizations have been urged to respond to public concerns...

Dementia RAISR4D

07/08/2026

Concordance Between [18F]Flortaucipir PET Visual Reads and CenTauR-Based Quantification

J Nucl Med. 2026 Aug 6:jnumed.126.272722. doi: 10.2967/jnumed.126.272722. Online ahead of print.ABSTRACTTau PET imaging with [18F]flortaucipir allows for the visualization and mapping of aggregated tau...

Dementia RAISR4D

07/08/2026

Long-term low-salt and high-salt diets differentially disrupt the gut-metabolite-brain axis and induce cognitive impairment

Food Res Int. 2026 Oct 1;241:119719. doi: 10.1016/j.foodres.2026.119719. Epub 2026 Jun 13.ABSTRACTLong-term high-salt diets (HSD) are known to impair cognitive function, whereas the effects of...

Dementia RAISR4D

07/08/2026

Family history of cognitive impairment as a diagnostic clue in Fragile X-associated tremor/ataxia syndrome

BMJ Case Rep. 2026 Aug 6;19(8):e273818. doi: 10.1136/bcr-2026-273818.ABSTRACTFragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by premutation alleles (55-200 CGG repeats) in the...

Dementia RAISR4D

07/08/2026

Psychosocial Pathways Between Physical Activity and Mild Cognitive Impairment in Community-Dwelling Older Adults: Mediation and Moderation Analyses

J Aging Health. 2026 Aug 6:8982643261475378. doi: 10.1177/08982643261475378. Online ahead of print.ABSTRACTObjectiveTo examine whether physical activity (PA) relates to mild cognitive impairment (MCI) both directly...

Dementia RAISR4D

07/08/2026

Sources of Active Brain White Matter Injury in Virally Suppressed HIV Infection Revealed Through Fixel-Based Analysis

J Acquir Immune Defic Syndr. 2026 Aug 6. doi: 10.1097/QAI.0000000000003946. Online ahead of print.ABSTRACTBACKGROUND: To better understand HIV and cardiovascular disease (CVD) effects on brain...

Dementia RAISR4D

06/08/2026

Chronic neurological diseases with acute respiratory failure in a real-life cohort: insights into ICU and long-term survival-A retrospective study

J Clin Neurosci. 2026 Aug 5;153:112228. doi: 10.1016/j.jocn.2026.112228. Online ahead of print.ABSTRACTBACKGROUND: Patients with chronic neurological diseases (CND) are at increased risk of pulmonary complications...

Dementia RAISR4D

06/08/2026

Esketamine alleviates neuroinflammation and cognitive impairment in male 3xTg-AD mice by regulating the TAOK1/IL-17 axis

Can J Physiol Pharmacol. 2026 Aug 5. doi: 10.1139/cjpp-2025-0340. Online ahead of print.ABSTRACTBeyond its antidepressant effects, esketamine (ESK) has the potential to enhance neuroplasticity, facilitating...

Dementia RAISR4D

05/08/2026

NanoBiT screening identifies the azaoxafluorene VT11 as potent tau interaction inhibitor

Sci Rep. 2026 Aug 4;16(1):24013. doi: 10.1038/s41598-026-65368-w.ABSTRACTTauopathies are neurodegenerative disorders characterized by accumulating misfolded, insoluble tau protein aggregates in neurons or glial cells. In this...

Dementia RAISR4D

05/08/2026

Access to Primary Care and Nephrology: Implications for Preemptive Listing and Kidney Transplantation, A National Registry Study

J Gen Intern Med. 2026 Aug 4. doi: 10.1007/s11606-026-10669-z. Online ahead of print.ABSTRACTBACKGROUND: Care coordination between primary care providers and nephrologists is crucial for preemptive...

Dementia RAISR4D

05/08/2026

Super-Resolution of Through-Plane Undersampled MRIs in Alzheimer’s Disease Diagnosis

J Imaging Inform Med. 2026 Aug 4. doi: 10.1007/s10278-026-02159-9. Online ahead of print.ABSTRACTAlzheimer's disease is a complex neurodegenerative disorder and the leading cause of dementia...

Dementia RAISR4D

05/08/2026

Retraction notice to “Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer’s disease: CLIC4 protein expression and tau protein hyperphosphorylation” [Int. J. Biol. Macromol. 278 (2024) 134972]

Int J Biol Macromol. 2026 Aug 4:153849. doi: 10.1016/j.ijbiomac.2026.153849. Online ahead of print.NO ABSTRACTPMID:42552207 | DOI:10.1016/j.ijbiomac.2026.153849

Dementia RAISR4D

05/08/2026

Homeostatic DNMT3a Activity Is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer’s Disease

Aging Dis. 2025 Jun 20;17(5):2710-2739. doi: 10.14336/AD.2025.0283.ABSTRACTDysregulation of DNA methylation has been implicated in Alzheimer's disease (AD), making the manipulation of DNA methylation processes a...

Dementia RAISR4D

05/08/2026

Energetic crisis, mitochondrial vulnerability and disruption of lactate shuttle in Alzheimer’s disease

Int Rev Neurobiol. 2026;188:67-89. doi: 10.1016/bs.irn.2026.05.012. Epub 2026 May 28.ABSTRACTAlzheimer's disease (AD) has traditionally been characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. Emerging evidence...

Dementia RAISR4D

05/08/2026

Metabolic dysregulation in Alzheimer’s disease: Mechanisms, markers, and therapeutic prospects

Int Rev Neurobiol. 2026;188:397-434. doi: 10.1016/bs.irn.2026.05.011. Epub 2026 May 26.ABSTRACTMetabolic dysregulation has emerged as a crucial pathogenic factor that contributes in progression of Alzheimer's disease...

Dementia RAISR4D

05/08/2026

Brain lipid dysregulation as a driver of energy metabolism failure in Alzheimer’s disease

Int Rev Neurobiol. 2026;188:363-396. doi: 10.1016/bs.irn.2026.02.004. Epub 2026 Mar 14.ABSTRACTAlzheimer's Disease (AD) is becoming more widely recognized as a condition of brain energy metabolism, wherein...

Dementia RAISR4D

05/08/2026

Brain energy metabolism changes and neuropsychological impairment in Parkinson disease vs Alzheimer disease

Int Rev Neurobiol. 2026;188:33-66. doi: 10.1016/bs.irn.2026.06.001. Epub 2026 Jun 23.ABSTRACTAlzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders, posing a significant...

Dementia RAISR4D

05/08/2026

The Tau-mitochondria connection and its impact on cellular energy metabolism in Alzheimer’s disease

Int Rev Neurobiol. 2026;188:299-361. doi: 10.1016/bs.irn.2026.06.002. Epub 2026 Jul 3.ABSTRACTAlzheimer's disease (AD) is a complex multifactorial neurodegenerative disease process resulting in progressive cognitive deterioration and...

Dementia RAISR4D

04/08/2026

Action naming in French: Normative data and response latencies for 134 video stimuli

Behav Res Methods. 2026 Aug 3;58(9):256. doi: 10.3758/s13428-026-03131-9.ABSTRACTIn spite of the inherently dynamic nature of actions, most psycholinguistic studies investigating action naming have relied on...

Dementia RAISR4D

04/08/2026

Changes in salivary brain-derived neurotrophic factor following a standardized eating task in community-dwelling older adults: a cross-sectional study

Odontology. 2026 Aug 3. doi: 10.1007/s10266-026-01526-w. Online ahead of print.ABSTRACTWhile mastication is suggested to influence cognitive function, evidence regarding its relationship with brain-derived neurotrophic factor...

Dementia RAISR4D

04/08/2026

Biomarker-Conditioned Vision Transformers with Deformable Biomarker Attention for Alzheimer’s Disease Classification

J Imaging Inform Med. 2026 Aug 3. doi: 10.1007/s10278-026-02152-2. Online ahead of print.ABSTRACTAlzheimer's disease (AD) classification from structural magnetic resonance imaging (MRI) remains challenging, particularly...

Dementia RAISR4D

04/08/2026

Neural Stem Cells in Multiple Sclerosis: A Comprehensive Review of Preclinical and Clinical Evidence for CNS Repair and Translational Hurdles

Appl Biochem Biotechnol. 2026 Aug 4. doi: 10.1007/s12010-026-05865-w. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is a chronic, immune-mediated, neurodegenerative disease of the central nervous system...

Dementia RAISR4D

04/08/2026

Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model

EMBO Mol Med. 2026 Aug 3. doi: 10.1038/s44321-026-00482-w. Online ahead of print.ABSTRACTEpidemiological studies have shown that lower activity of the cholesteryl ester transfer protein (CETP)...

Dementia RAISR4D

04/08/2026

CD44 as a Conserved Biomarker and Functional Modulator of Neuroinflammation in Multiple Sclerosis and Beyond

Mol Neurobiol. 2026 Aug 4;63(1):805. doi: 10.1007/s12035-026-06107-0.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, blood-brain barrier...

Dementia RAISR4D

04/08/2026

Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults – results from the ActiFE study

Eur J Clin Pharmacol. 2026 Aug 4;82(8):225. doi: 10.1007/s00228-026-04155-y.ABSTRACTPURPOSE: To investigate the role of CYP2D6 and its pharmacogenetic variability in the association between anticholinergic burden...

Dementia RAISR4D

04/08/2026

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

Commun Chem. 2026 Aug 1;9(1):263. doi: 10.1038/s42004-026-02108-1.ABSTRACTThe aggregation of the tau protein into intraneuronal fibrillar tangles is closely associated with the pathology of Alzheimer's disease....

Dementia RAISR4D

04/08/2026

Letter: Olanzapine in Parkinson disease and dementia with Lewy bodies

Cleve Clin J Med. 2026 Aug 3;93(8):452-453. doi: 10.3949/ccjm.93c.08003.NO ABSTRACTPMID:42547282 | DOI:10.3949/ccjm.93c.08003

Dementia RAISR4D

04/08/2026

In Reply: Olanzapine in Parkinson disease and dementia with Lewy bodies

Cleve Clin J Med. 2026 Aug 3;93(8):453. doi: 10.3949/ccjm.93c.08004.NO ABSTRACTPMID:42547276 | DOI:10.3949/ccjm.93c.08004

Dementia RAISR4D

03/08/2026

Research progress on active ingredients of Astragali Radix and Acori Tatarinowii Rhizoma and mechanism of their herb pair against Alzheimer’s disease

Zhongguo Zhong Yao Za Zhi. 2026 Jun;51(11):3152-3159. doi: 10.19540/j.cnki.cjcmm.20260209.501.ABSTRACTAlzheimer's disease(AD) is a highly prevalent neurodegenerative disorder with complex pathogenesis. Currently available mainstream drugs offer limited...

Dementia RAISR4D

03/08/2026

Gait Impairment and Alzheimer’s Disease Pathology: A Narrative Review on Mechanistic Links

Geriatr Gerontol Int. 2026 Aug;26(8):e70675. doi: 10.1111/ggi.70675.ABSTRACTIn older adults, gait has emerged as an important indicator of overall health and a strong predictor of adverse...

Dementia RAISR4D

03/08/2026

Perceived Level of Dementia Person-Centered Care Among Indonesian Care Staff Working in Japanese Hospitals and Long-Term Care Facilities and Their Relation to Staff Personal and Organizational Factors: A Cross-Sectional Study

Geriatr Gerontol Int. 2026 Aug;26(8):e70684. doi: 10.1111/ggi.70684.ABSTRACTAIM: This study investigated the association between the staff's personal characteristics and organizational factors with the perceived level of...

Dementia RAISR4D

03/08/2026

Brain aging clocks: From methodological advances to cellular mechanisms

Exp Gerontol. 2026 Aug 2:113260. doi: 10.1016/j.exger.2026.113260. Online ahead of print.ABSTRACTBrain aging represents a critical risk factor for neurodegenerative diseases and cognitive decline, yet the...

Dementia RAISR4D

02/08/2026

Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer’s disease and advanced Alzheimer’s disease

Acta Neuropathol. 2026 Aug 1;152(1):13. doi: 10.1007/s00401-026-03064-9.ABSTRACTAlzheimer's disease (AD) is characterised by the intraneuronal aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles and by the...

Dementia RAISR4D

02/08/2026

Advancing Alzheimer’s disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer’s disease study (CPAS)

Mol Psychiatry. 2026 Aug 1. doi: 10.1038/s41380-026-03797-9. Online ahead of print.ABSTRACTThis review delves into the advancements in Alzheimer's Disease (AD) research in China, focusing on...

Dementia RAISR4D

02/08/2026

The prevalence and impact of medication-related harm in people living with dementia – a systematic review and meta-analysis

Res Social Adm Pharm. 2026 Jul 29:S1551-7411(26)00171-3. doi: 10.1016/j.sapharm.2026.07.011. Online ahead of print.ABSTRACTOBJECTIVE: People living with dementia (PLWD) take more medications than those without dementia,...

Dementia RAISR4D

02/08/2026

Emergency care for patients with MA: the key role of IPA

Soins Gerontol. 2026 Jul-Aug;31(180):23-25. doi: 10.1016/j.sger.2026.06.006. Epub 2026 Jul 20.ABSTRACTThe importance of advanced practice nurses (APNs) in improving emergency care for patients with Alzheimer's disease...

Dementia RAISR4D

01/08/2026

Heterogeneity in the association between APOE epsilon4 carrier status and dementia risk by modifiable and non-modifiable risk factors

Geroscience. 2026 Jul 31. doi: 10.1007/s11357-026-02452-z. Online ahead of print.ABSTRACTDementia is a major public health challenge, and Apolipoprotein E (APOE) ε4 is strongly associated with...

Dementia RAISR4D

01/08/2026

Central nervous system histopathological findings in classic infantile Pompe disease: a systematic review with clinical relevance

J Neurol. 2026 Jul 31;273(8):496. doi: 10.1007/s00415-026-13991-y.ABSTRACTINTRODUCTION: Classic infantile Pompe disease is the most severe phenotype within the clinical spectrum of Pompe disease and is...

Dementia RAISR4D

01/08/2026

Multi-theory model-based exercise for cognition, physical fitness, and quality of life in patients with lymphoma during chemotherapy: a randomized controlled trial

J Cancer Surviv. 2026 Jul 31. doi: 10.1007/s11764-026-02093-3. Online ahead of print.ABSTRACTPURPOSE: To evaluate the effects of a multi-theory model (MTM)-based exercise program on cognitive...

Dementia RAISR4D

01/08/2026

Pilot randomised controlled trial of an e-cigarette and tobacco use intervention for hospitalised youth

Tob Control. 2026 Jul 31:tc-2025-060006. doi: 10.1136/tc-2025-060006. Online ahead of print.ABSTRACTINTRODUCTION: We sought to evaluate preliminary efficacy and implementation outcomes of an e-cigarette and tobacco...

Dementia RAISR4D

01/08/2026

Comparative efficacy of digital cognitive training regimens on verbal fluency in older adults: A systematic review and network meta-analysis

Int Psychogeriatr. 2026 Jul 31:100246. doi: 10.1016/j.inpsyc.2026.100246. Online ahead of print.ABSTRACTBACKGROUND: Verbal fluency is a core marker for early cognitive decline in older adults. This...

Dementia RAISR4D

31/07/2026

Comorbidities in multiple sclerosis: acquired hepatocerebral degeneration mimicking disease progression

Neurol Sci. 2026 Jul 31;47(8):670. doi: 10.1007/s10072-026-09284-x.ABSTRACTA 63-year-old patient with relapsing-remitting multiple sclerosis (MS) and comorbid liver cirrhosis presented with progressive cognitive decline, gait disturbance...

Dementia RAISR4D

31/07/2026

A NOTCH3 p.Gly1105Cys variant in CADASIL: clinical characterization and an updated overview of exon 20 variants

Neurol Sci. 2026 Jul 31;47(8):667. doi: 10.1007/s10072-026-09271-2.ABSTRACTCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an autosomal dominant cerebrovascular disorder caused by NOTCH3 variants....

Dementia RAISR4D

31/07/2026

Author Correction: Sleep chart of biological ageing clocks in middle and late life

Nature. 2026 Jul 30. doi: 10.1038/s41586-026-10920-x. Online ahead of print.NO ABSTRACTPMID:42533160 | DOI:10.1038/s41586-026-10920-x

Dementia RAISR4D

31/07/2026

The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders

Nat Neurosci. 2026 Jul 30. doi: 10.1038/s41593-026-02359-0. Online ahead of print.ABSTRACTDecades of structural magnetic resonance imaging (MRI) studies have documented alterations of gray matter morphometry...

Dementia RAISR4D

31/07/2026

Agentic AI for scaling diagnosis and care in neurodegenerative disease

Nat Aging. 2026 Jul 30. doi: 10.1038/s43587-026-01186-z. Online ahead of print.ABSTRACTUS healthcare systems are struggling to meet the growing demand for neurological care, particularly in...

Dementia RAISR4D

30/07/2026

Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline: An 8-Year Prospective Study

Neurology. 2026 Aug 25;107(4):e218380. doi: 10.1212/WNL.0000000000218380. Epub 2026 Jul 30.NO ABSTRACTPMID:42531540 | DOI:10.1212/WNL.0000000000218380

Dementia RAISR4D

30/07/2026

VasCog-2-WSO Criteria for Vascular Cognitive Impairment and Dementia: A Revised Standard Put to the Test

Neurology. 2026 Aug 25;107(4):e218461. doi: 10.1212/WNL.0000000000218461. Epub 2026 Jul 30.NO ABSTRACTPMID:42531539 | DOI:10.1212/WNL.0000000000218461

Dementia RAISR4D

30/07/2026

Validation of the VasCog-2-WSO VCID Criteria in a Dementia-Free and Stroke-Free Community Cohort: Cardiovascular Risk and Mortality

Neurology. 2026 Aug 25;107(4):e218311. doi: 10.1212/WNL.0000000000218311. Epub 2026 Jul 30.ABSTRACTBACKGROUND AND OBJECTIVES: Vascular cognitive impairment and dementia (VCID), a major contributor of dementia, remains underrecognized,...

Dementia RAISR4D

30/07/2026