- Case-control study measured micronuclei and nuclear bud frequencies in oral exfoliated cells from ALS patients (n=20) and matched controls (n=20).
- Groups matched for age, sex, and lifestyle, with no significant differences in MNi or NBUD frequencies (p>0.05).
- Results indicate no association between ALS and MN/NBUD frequencies in oral cells, limiting their utility as biomarkers in this cohort.
Mutat Res Genet Toxicol Environ Mutagen. 2026 Jul;913:503953. doi: 10.1016/j.mrgentox.2026.503953. Epub 2026 Jul 30.
ABSTRACT
Genetic instability has been reported in several neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, but only a few studies have addressed sclerosis. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Micronuclei (MNi) and nuclear buds (NBUDs) are established markers of chromosomal instability, yet no data are available regarding a possible link between genetic instability and ALS. The novelty of this case-control study lies in the assessment of genetic instability in oral exfoliated cells from ALS patients (n = 20) and matched controls (n = 20), contributing to the identification of potential novel markers related to the molecular pathogenesis of this severe disorder. Groups were matched for age, sex, and lifestyle (p > 0.05). No significant differences were observed in MNi or NBUD frequencies between groups (p > 0.05). These findings suggest no association between ALS and MN/NBUD frequencies in oral cells.
PMID:42580784 | DOI:10.1016/j.mrgentox.2026.503953
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
