- Insomnia symptoms prospectively predicted subsequent depressive and anxiety symptoms, with statistically significant but modest effect sizes.
- Depressive symptoms also predicted later anxiety and insomnia, notably predicting anxiety with larger effect size than other pathways.
- Anxiety symptoms did not significantly predict later insomnia or depression; overall bidirectional effects were small and temporal ordering remains unclear.
J Clin Psychol. 2026 Aug 11. doi: 10.1002/jclp.70207. Online ahead of print.
ABSTRACT
OBJECTIVES: While some research suggests that increases in anxiety symptoms drive changes in insomnia and depression symptoms, other studies support that these relations may be bidirectional. The present study therefore aimed to further examine how anxiety, insomnia and depression symptoms predict changes in these symptoms over time.
METHODS: Participants were recruited via an online participant database, social media advertisements, and other online sites, resulting in a large sample (N = 2,666) of adults from across the United States. Well validated instruments were used to measure symptoms of depression (CES-D), anxiety (STAI), and insomnia (ISI). Data were collected via a series of Qualtrics surveys administered online at two time points: March-June 2020 (baseline) and January-March 2021 (follow-up).
RESULTS: Insomnia symptoms (β = 0.142, p < 0.001) but not anxiety symptoms (β = 0.019, p = 0.445) significantly predicted depression symptoms. Depression symptoms (β = 0.077, p = 0.001) but not anxiety symptoms (β = 0.039, p = 0.075) significantly predicted insomnia symptoms. Both insomnia (β = 0.060, p = 0.001) and depression symptoms (β = 0.281, p < 0.001) significantly predicted anxiety symptoms. Although multiple cross-lagged paths were statistically significant, effect sizes were generally small, and no single pathway was meaningfully stronger than others. Additionally, secondary exploratory mediation models revealed significant indirect effects between anxiety and depression through insomnia (model 1 indirect β = 0.027, p = 0.007; model 2 indirect β = 0.008, p = 0.036).
CONCLUSIONS: Findings suggest that insomnia symptoms were prospectively associated with subsequent depressive and anxiety symptoms. Depression symptoms also predicted later anxiety symptoms, highlighting the complex longitudinal associations among these symptom domains. However, results did not support a temporal pathway in which anxiety precedes the development of comorbid insomnia. Future studies should assess temporal order more closely, using high density longitudinal sampling strategies (i.e., more than two data collection points) to further clarify the temporal ordering of these symptom domains.
PMID:42579862 | DOI:10.1002/jclp.70207
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