Cedrol Improved Liver and Kidney Injuries in Lipopolysaccharide-Exposed Rats

Adv Biomed Res. 2025 Dec 30;14:170. doi: 10.4103/abr.abr_76_25. eCollection 2025.

ABSTRACT

BACKGROUND: Cedrol has anti-inflammatory and antioxidant properties. We evaluated effect of cedrol on lipopolysaccharide (LPS) – caused liver and kidney damage.

MATERIALS AND METHODS: The animals included control, LPS, LPS-cedrol 7.5, LPS-cedrol 15, and LPS-cedrol 30. Cedrol (7.5, 15, and 30 mg/kg) was used orally 30 min before LPS for 2 weeks. Blood concentrations of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALK-P), urea, and creatinine were checked. Tissue level of tumor necrosis factor alpha (TNF-α), malondialdehyde (MDA), total thiol and superoxide dismutase (SOD), and catalase (CAT) activity was also measured.

RESULTS: Results indicated that LPS elevated the level of TNF-α, MDA, ALT, AST, ALK-P, urea, and creatinine (P < 0.01 and P < 0.001). LPS also decreased total thiol concentration and SOD and CAT activity (P < 0.001). Treatment with 30 mg/kg of cedrol reduced the level of TNF-α, MDA, and urea (P < 0.01 and P < 0.001) and enhanced thiol content (P < 0.001) in the LPS-cedrol 30 group versus the LPS group. Results exhibited that 15 and 30 mg/kg of cedrol increased SOD and CAT activity (P < 0.01 and P < 0.001) and mitigated the level of AST, ALT, ALK-P, and creatinine (P < 0.05, P < 0.01, and P < 0.001) in LPS-cedrol 15 and LPS-cedrol 30 groups versus the LPS group.

CONCLUSION: Anti-inflammatory and antioxidant properties of cedrol protected liver and kidney damage in LPS-exposed rats. Based on the results, use of cedrol was recommended as a strategy for protecting organs against inflammation and oxidative stress.

PMID:41669289 | PMC:PMC12885209 | DOI:10.4103/abr.abr_76_25