- Network analysis identified nervousness or anxiety, little interest or pleasure in doing things, and fear of being unable to pursue hobbies as most central symptoms.
- Bridge symptoms linking domains were restlessness, fear that something awful might happen, inability to control worry, and little interest or pleasure.
- High prevalence: 55.7% depression, 56.8% anxiety, and 88.5% fear of disease progression, suggesting symptom-level intervention targets.
J Health Psychol. 2026 Aug 11:13591053261475628. doi: 10.1177/13591053261475628. Online ahead of print.
ABSTRACT
Anxiety, depression, and fear of disease progression commonly co-occur in patients with chronic diseases, yet, to our knowledge, no previous study has used network analysis to identify the central and bridge symptoms linking these domains in Saudi patients. This study examined symptom interrelationships in 271 Saudi patients with chronic diseases recruited from multiple health centers in Jeddah and Riyadh. Participants completed the PHQ-9, GAD-7, and the Fear of Progression Questionnaire-Short Form. Network analysis showed that nervousness/anxiety, little interest or pleasure in doing things, and fear of being unable to pursue hobbies were the most central symptoms. The main bridge symptoms were restlessness, fear that something awful might happen, inability to control worry, and little interest or pleasure in doing things. Elevated depressive, anxiety, and fear of disease progression symptoms were reported by 55.7%, 56.8%, and 88.5% of participants, respectively. These findings identify potential symptom-level intervention targets.
PMID:42581667 | DOI:10.1177/13591053261475628
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