Cognitive function in central disorders of hypersomnolence

18/09/2026

AI Summary

Cognitive dysfunction is a core, disabling feature across CDH subtypes, impairing attention, processing speed, memory and executive function.
Nature and magnitude of deficits vary by subtype and reflect distinct neurobiological mechanisms and comorbidity interactions.
Understanding treatment responsiveness and clinical consequences informs practical assessment and management frameworks for clinicians and neuroscientists.

TL;DR (AI Generated)

Cognitive dysfunction is a core, disabling feature of the CDH spectrum, affecting attention, processing speed, memory, and executive function to varying degrees across subtypes.

This chapter reviews current evidence on the nature, magnitude, neurobiological mechanisms, comorbidity interactions, treatment responsiveness, and clinical consequences of cognitive impairment in CDH, and aims to give the clinical neuroscientist and sleep specialist a practical framework.

Basic summary

Prog Brain Res. 2026;301:37-59. doi: 10.1016/bs.pbr.2026.08.003. Epub 2026 Sep 12.

ABSTRACT

Central disorders of hypersomnolence (CDH), a group that includes narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine-Levin syndrome (KLS), are defined by excessive daytime sleepiness (EDS) and prolonged or fragmented sleep, but their impact extends well beyond wakefulness. Cognitive dysfunction is a core, disabling feature of the CDH spectrum, affecting attention, processing speed, memory, and executive function to varying degrees across subtypes. This chapter reviews current evidence on the nature, magnitude, neurobiological mechanisms, comorbidity interactions, treatment responsiveness, and clinical consequences of cognitive impairment in CDH, and aims to give the clinical neuroscientist and sleep specialist a practical framework.

PMID:42754325 | DOI:10.1016/bs.pbr.2026.08.003

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