- Combined PLR and VAS provide synergistic prediction of patient self-perception deterioration in rheumatoid arthritis.
- High VAS independently predicts SPP deterioration; dual-high PLR and VAS markedly increase risk of impaired mental health and TCM spleen deficiency.
- The dual-high phenotype may be a simple auxiliary marker for targeted monitoring and personalised management, pending prospective validation.
Front Med (Lausanne). 2026 Jul 1;13:1836171. doi: 10.3389/fmed.2026.1836171. eCollection 2026.
ABSTRACT
OBJECTIVE: To explore the independent and synergistic predictive value of platelet/lymphocyte ratio (PLR) and visual analogue scale (VAS) for multidimensional self-perception of patient (SPP) in rheumatoid arthritis (RA), and to support high-risk population stratification.
METHODS: A total of 708 RA patients were enrolled and categorized into four groups according to the median levels of PLR and VAS. Correlation and multivariate logistic regression analyses were adopted to evaluate their associations with SPP.
RESULTS: PLR and VAS were closely correlated with multidimensional SPP abnormalities. High VAS served as an independent risk factor for SPP deterioration. Combined high PLR and high VAS exhibited a prominent synergistic effect, greatly increasing the risk of impaired mental health and TCM spleen deficiency with dampness syndrome.
CONCLUSION: Combined PLR and VAS assessment offers synergistic predictive value for SPP deterioration in RA. The dual-high phenotype can serve as a simple auxiliary marker for identifying high-risk RA patients to facilitate targeted monitoring and personalized management, with further prospective validation still required.
PMID:42460075 | PMC:PMC13368734 | DOI:10.3389/fmed.2026.1836171
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