- Excessive censoring reduces quality of individual cortical parcellations and personalised TMS targets; lenient censoring yields higher quality at equivalent motion levels.
- Lenient censoring improvements are comparable to doubling scan duration from 20 to 40 minutes under strict censoring.
- For clinical practice, re-scanning may be unnecessary; lenient censoring of high-motion sessions produces TMS targets comparable or superior to strictly censored mixed-motion sessions.
Imaging Neurosci (Camb). 2026 Nov 2;4:IMAG.a.1422. doi: 10.1162/IMAG.a.1422. eCollection 2026.
ABSTRACT
Head motion systematically biases functional connectivity (FC) estimates in resting-state functional MRI (rs-fMRI). A common mitigation strategy is to censor high-motion volumes and discard high-motion runs. However, overly stringent censoring risks discarding signal alongside noise, potentially degrading FC estimates. Here, we test the efficacy of various censoring strategies on individual-specific cortical parcellations and personalized transcranial magnetic stimulation (TMS) target selection. Using precision-fMRI datasets comprising 50 individuals, we define individualized “ground-truth” references from ≥1 hour of low-motion data per participant. We then simulate 10-minute or 20-minute rs-fMRI sessions with varying motion levels from the remaining data, yielding final samples of 22 and 19 participants, respectively. Higher motion produces parcellations and TMS targets that deviate further from the ground-truth references. However, at any given motion level, lenient censoring produces higher quality parcellations and personalized TMS targets than strict censoring. The improvement is comparable to doubling scan duration from 20 to 40 minutes under strict censoring. With personalized connectome-guided TMS, a common dilemma is whether to re-scan patients with only high-motion runs. A mixed-motion session with one low-motion run and one high-motion run may often be considered usable after discarding the high-motion run and strict censoring. We find that lenient censoring of high-motion-only sessions yields TMS targets comparable to-or even better than-those derived from strictly censored mixed-motion sessions. Therefore, within the motion range and parcellation/TMS targeting frameworks evaluated here, patients may not need to be re-scanned solely because all runs exceed strict censoring criteria.
PMID:42978984 | PMC:PMC13728936 | DOI:10.1162/IMAG.a.1422
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
