AI Summary
- Gait disturbances are associated with Alzheimer's pathology, but causal and temporal relationships remain unresolved, hindering mechanistic understanding and early detection.
- Recommend longitudinal, multimodal studies integrating gait metrics, neuroimaging, fluid biomarkers, and neuropathology to clarify mechanisms and temporal ordering.
- Address methodological issues: standardised gait measures, confounder control, sensitive biomarkers, representative cohorts, and preclinical stage focus for robust inference.
Geriatr Gerontol Int. 2026 Aug;26(8):e70799. doi: 10.1111/ggi.70799.
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PMID:42586939 | DOI:10.1111/ggi.70799
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