Evidence
Ther Apher Dial. 2023 May 21. doi: 10.1111/1744-9987.14002. Online ahead of print.
ABSTRACT
INTRODUCTION: Little is known about the impact of plasma exchange (PE) on clinical laboratory parameters in Alzheimer’s disease (AD) patients.
METHODS: AD patients in the AMBAR trial (N = 322) received weekly therapeutic PE (TPE) for 6 weeks followed by monthly low-volume PE (LVPE) for12 months. Treatment were placebo (sham PE), low-albumin, low-albumin + IVIG (i.e., albumin alternated with intravenous immunoglobulin) and high-albumin + IVIG.
RESULTS: Coagulation parameters transiently increased post-TPE. Blood calcium, platelets, and albumin levels decreased but remained within the reference range. Leukocyte counts increased. Fibrinogen, hemoglobin, total protein, gamma globulin, and IgG, transiently dipped below the reference range. Hypogammaglobulinemia (7.2 g/L) persisted in pre-TPE measurements. No changes were observed during the LVPE period. Cerebrospinal fluid parameters and vital signs were unchanged throughout.
CONCLUSION: Laboratory parameters of AD patients were affected by TPE similarly to effects of PE-treatment for other pathologies. These effects were less pronounced or non-existent for LVPE.
PMID:37211527 | DOI:10.1111/1744-9987.14002
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer’s disease from the AMBAR study
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Serum albumin and white matter hyperintensities
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Role of albumin infusion in cirrhosis-associated complications
- Transfusion-associated acute lung injury following albumin treatment in liver disease
- Transfusion-associated acute lung injury following albumin treatment in liver disease
- Observational Study of Clinical Profiles and Management of Liver Abscess in Hospitalized Patients: A North Indian Tertiary Care Perspective
- Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- Evaluation of Systemic and Brain Pharmacokinetic Parameters for Repurposing Metformin Using Intravenous Bolus Administration
- Post-COVID anxiety, depression, and quality of life among Egyptian hemodialysis patients
- Inter-relationships of risk factors and pathways associated with all-cause mortality in patients with chronic schizophrenia
- Mouse serum albumin induces neuronal apoptosis and tauopathies
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barré syndrome
- Non-linear relationship of serum albumin-to-globulin ratio and cognitive function in American older people: a cross-sectional national health and nutrition examination survey 2011-2014 (NHANES) study
- Non-linear relationship of serum albumin-to-globulin ratio and cognitive function in American older people: a cross-sectional national health and nutrition examination survey 2011-2014 (NHANES) study
- Relationship between nutrition indicators and pneumonia risk among stable schizophrenia patients: a retrospective study
- Evaluation of peripheral inflammatory parameters of cases with suicide attempts
- Combining hemodialysis with peritoneal dialysis improves cognitive function: a three-case report
- Donanemab in Japanese Patients with Early Alzheimer's Disease: Subpopulation Analysis of the TRAILBLAZER-ALZ 2 Randomized Trial
- Long-term follow-up of relapse and remission of CIDP in a Chinese cohort
- Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters
- Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters
- The effect of soy isoflavones supplementation on metabolic status in patients with non-alcoholic fatty liver disease: a randomized placebo controlled clinical trial
- The effect of soy isoflavones supplementation on metabolic status in patients with non-alcoholic fatty liver disease: a randomized placebo controlled clinical trial
- The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease
- Effects of low fat diet on inflammatory parameters in individuals with obesity/overweight and non-alcoholic fatty liver disease: A cross-sectional study
- The effect of indicators of CALLY index on survival in glioblastoma
- Blood biomarkers open a window to brain pathophysiology in Alzheimer's disease
- Keratoconus and Corneal Ectasia with Relatively Low Keratometry
- Is Reiki effective in reducing heart rhythm, cortisol and anxiety and improving biochemical parameters in individuals with cardiac disesase? Randomized placebo-controlled trial
- Body composition impacts outcome of bronchoscopic lung volume reduction in patients with severe emphysema: a fully automated CT-based analysis
- MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial
- Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment
- Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population
- Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial
- Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial
- Guillain-Barré syndrome: A comprehensive review
- Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial
- Plasma biomarkers increase diagnostic confidence in patients with Alzheimer's disease or frontotemporal lobar degeneration
- Association between paravertebral muscle radiological parameter alterations and non-alcoholic fatty liver disease
- Association between paravertebral muscle radiological parameter alterations and non-alcoholic fatty liver disease
- Association between paravertebral muscle radiological parameter alterations and non-alcoholic fatty liver disease
- Examining barriers to care: a retrospective cohort analysis investigating the relationship between hospital volume and outcomes in pediatric patients with cerebral arteriovenous malformations
- Absence of Evidence for Sustained Effects of Daily Cannabidiol Administration on Anandamide Plasma Concentration in Individuals with Cocaine Use Disorder: Exploratory Findings from a Randomized Controlled Trial
- Nutritional Intervention Leads to Successful Re-pregnancy of Pregnant Women with Severe Preeclampsia: A Case Report
- The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study
- Altering plasma lipids and liver enzyme activities via hippocampal injections of hen Lysozyme amyloid aggregates in an Alzheimer's disease mouse model: Insights into the therapeutic role of Bis (Indolyl) phenylmethane
- Effect of vitamin D supplementation on various parameters in patients with non-alcoholic fatty liver disease: An updated meta-analysis
- Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model
- Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults
- Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults
- Analysis of clinical treatment of acute respiratory distress syndrome assisted by artificial intelligence
- Circulating extracellular vesicles as biomarker for diagnosis, prognosis and monitoring in glioblastoma patients
- Prunin from Poncirus trifoliata (L.) Rafin Inhibits Aldose Reductase and Glucose-Fructose-Mediated Protein Glycation and Oxidation of Human Serum Albumin
- Ubiquity of Synthetic Phenolic Antioxidants in Children's Cerebrospinal Fluid from South China: First Evidence for Their Penetration across the Blood-Cerebrospinal Fluid Barrier
- Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
- Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis
- The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
- Design and application of Cd2+ polypeptide fluorescent probes based on Aggregation Induced Emission (AIE)
- Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients
Evidence Blueprint
Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer’s disease from the AMBAR study
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer’s disease from the AMBAR study
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Serum albumin and white matter hyperintensities
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Role of albumin infusion in cirrhosis-associated complications
- Albumin, an interesting and functionally diverse protein, varies from 'native' to 'effective' (Review)
- Transfusion-associated acute lung injury following albumin treatment in liver disease
- Transfusion-associated acute lung injury following albumin treatment in liver disease
- Long-term outcomes of plasma exchange versus intravenous immunoglobulin for the treatment of Guillain-Barré Syndrome: A double-blind, randomized clinical trial
- Association between albumin and depression: a population-based study
- Role of liver parameters in diabetes mellitus - a narrative review
- Observational Study of Clinical Profiles and Management of Liver Abscess in Hospitalized Patients: A North Indian Tertiary Care Perspective
- Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study
- Effects of esaxerenone on blood pressure, urinary albumin excretion, serum levels of NT-proBNP, and quality of life in patients with primary aldosteronism
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- Iron overload may be critical for liver dysfunction in anorexia nervosa, and the role of haematocrit-adjusted albumin in assessing nutritional status: a case report
- Thiol-disulphide homeostasis, ischemia-modified albumin, complete blood count-derived inflammatory markers and C-reactive protein from acute mania to early remission in bipolar disorder
- Evaluation of Systemic and Brain Pharmacokinetic Parameters for Repurposing Metformin Using Intravenous Bolus Administration
- Associations between liver function and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in non-demented adults: The CABLE study
- Post-COVID anxiety, depression, and quality of life among Egyptian hemodialysis patients
- Inter-relationships of risk factors and pathways associated with all-cause mortality in patients with chronic schizophrenia
- The Association of Nonalcoholic Fatty Liver Disease With Neutrophil-to-Lymphocyte Ratio and Neutrophil-Percentage-to-Albumin Ratio
- Mouse serum albumin induces neuronal apoptosis and tauopathies
- Risk factors of hepatocellular carcinoma in non-alcoholic fatty liver disease: a systematic review and meta-analysis
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization
- An Unusual Case of a Primary Hyperparathyroidism Mimic
- An Unusual Case of a Primary Hyperparathyroidism Mimic
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barré syndrome
- Non-linear relationship of serum albumin-to-globulin ratio and cognitive function in American older people: a cross-sectional national health and nutrition examination survey 2011-2014 (NHANES) study
- Non-linear relationship of serum albumin-to-globulin ratio and cognitive function in American older people: a cross-sectional national health and nutrition examination survey 2011-2014 (NHANES) study
- Risk factors for macro vascular disease in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease
- Inflammatory cerebrospinal fluid markers in schizophrenia spectrum disorders: A systematic review and meta-analysis of 69 studies with 5710 participants
- Serum uric acid level in chronic liver disease and its correlation with Child-Pugh score in a tertiary care hospital from South India
- Relationship between nutrition indicators and pneumonia risk among stable schizophrenia patients: a retrospective study
- Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis
- Albumin-fused thioredoxin ameliorates high-fat diet-induced non-alcoholic steatohepatitis
- Evaluation of peripheral inflammatory parameters of cases with suicide attempts
- Combining hemodialysis with peritoneal dialysis improves cognitive function: a three-case report
- Alcohol-related cancer morbidity and mortality are stratified using modified albumin platelet product
- Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients
- Outpatient albumin infusions reduce hospitalizations and improve outcomes in decompensated cirrhosis: A real-world cohort study
- Donanemab in Japanese Patients with Early Alzheimer's Disease: Subpopulation Analysis of the TRAILBLAZER-ALZ 2 Randomized Trial
- Treatment of Cognitive Deficits and Behavioral Symptoms Following COVID-19-Associated Autoimmune Encephalitis With Intravenous Immunoglobulin: A Case Report and Review of the Literature
- The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease
- Long-term follow-up of relapse and remission of CIDP in a Chinese cohort
- Imaging in hepatopulmonary syndrome-case report. A multicenter approach during the coronavirus pandemic
- Intellectual disability and autism in propionic acidemia: a biomarker-behavioral investigation implicating dysregulated mitochondrial biology
- Monitoring physiological processes of fast-growing broilers during the whole life cycle: Changes of redox-homeostasis effected to trassulfuration pathway predicting the development of non-alcoholic fatty liver disease
- Association Between Abnormal Metabolic Parameters and Receiving Subsequent Interventions in Children and Adolescents Initiating Second-Generation Antipsychotics
- Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters
- Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters
- TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease
- Impact of demographics and comorbid conditions on plasma biomarkers concentrations and their diagnostic accuracy in a memory clinic cohort
- Lipid and renal profile in assessing the severity of alcoholic liver disease
- The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study
- Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
- The effect of soy isoflavones supplementation on metabolic status in patients with non-alcoholic fatty liver disease: a randomized placebo controlled clinical trial
- The effect of soy isoflavones supplementation on metabolic status in patients with non-alcoholic fatty liver disease: a randomized placebo controlled clinical trial
- Diagnostic value of plasma SIRT1 levels and whole-brain gray matter volume in Parkinson's disease patients with cognitive impairment
- The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease
- Evaluation of Efficacy and Safety Using Low Dose Radiation Therapy with Alzheimer's Disease: A Protocol for Multicenter Phase II Clinical Trial
- A randomized placebo-controlled, double-blind study to investigate the effect of a high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients, new insights on serum STAT-3 and hepassocin
- Effects of low fat diet on inflammatory parameters in individuals with obesity/overweight and non-alcoholic fatty liver disease: A cross-sectional study