AI Summary
- Integration of transposable elements into blood gene regulatory networks reveals connectivity loss among schizophrenia-associated genes.
- In patients with schizophrenia, genes and the dark genome become disconnected, indicating altered regulatory interactions.
- This disconnect points to new avenues for blood-based diagnostics and therapeutic development for schizophrenia.
J Clin Invest. 2026 Sep 1;136(17):e203491. doi: 10.1172/JCI203491. eCollection 2026 Sep 1.
ABSTRACT
In patients with schizophrenia we found that genes and dark genome disconnect. This opens new areas for possible diagnostics and treatments.
PMID:42677838 | DOI:10.1172/JCI203491
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