AI Summary
- Current evidence does not establish a causal link between isotretinoin and adolescent suicidality; data are limited by confounding and methodological issues.
- Clinicians should screen and monitor mood symptoms, inform patients and guardians of potential risks, and manage psychiatric history proactively.
- High quality prospective studies and standardised reporting are needed to clarify risk, guide counselling, and balance isotretinoin's benefits against possible harms.
Pediatr Dermatol. 2026 Sep 29. doi: 10.1111/pde.70371. Online ahead of print.
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PMID:42810782 | DOI:10.1111/pde.70371
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