- Three bipolar depression patients developed mania within 10-14 days of starting lumateperone 42 mg/day; YMRS scores 26-29.
- Alternative causes were excluded; symptoms resolved after stopping lumateperone and optimising mood stabilisers; Naranjo scores 7-8 indicated probable drug association.
- Lumateperone may precipitate mania in susceptible individuals, necessitating close monitoring during the early treatment period.
Indian J Psychiatry. 2026 Aug;68(8):761-764. doi: 10.4103/indianjpsychiatry_1261_25. Epub 2026 Aug 20.
ABSTRACT
BACKGROUND: Lumateperone is an approved treatment for bipolar depression with a low reported risk of treatment-emergent mania. However, real-world evidence remains limited.
CASES: We describe three adults with bipolar depression who developed manic symptoms within 10-14 days of initiating lumateperone 42 mg/day. Young Mania Rating Scale scores ranged from 26 to 29. Alternative causes were excluded, symptoms resolved after discontinuing lumateperone and optimizing mood stabilizers, and Naranjo scores (7-8) indicated a probable drug association.
CONCLUSION: Lumateperone may precipitate mania in susceptible individuals, highlighting the need for close monitoring during the early treatment period.
PMID:42724943 | PMC:PMC13561462 | DOI:10.4103/indianjpsychiatry_1261_25
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