- Home-based cognitive assessments in the Mexican Teachers' Cohort proved feasible, with 153 of 186 located participants completing testing (82% participation).
- Brief tests (word recall, digit span, semantic fluency) yielded wide score ranges without floor or ceiling effects, supporting measurement validity.
- Participants (median age 61; 53% college educated) resembled non-participants, indicating representativeness for ageing research in Latin America.
Alzheimers Dement. 2026 Jun;22(6):e71569. doi: 10.1002/alz.71569.
ABSTRACT
INTRODUCTION: Expanding research on aging and cognition in low- and middle-income countries is critical, yet logistically complex. Large, established cohorts, such as the Mexican Teachers’ Cohort (MTC; >100,000 women), pose unique opportunities for neurocognitive research in Latin America.
METHODS: We evaluated the feasibility of home-based cognitive assessments in 150 Mexico City MTC participants, equally distributed across ages 55 to 59, 60 to 64, and ≥65. Tests included immediate/delayed word list recall, forward/backward digit span, and semantic verbal fluency.
RESULTS: Over 3 weeks, 274 homes were approached; 186 participants (56%) were at the known addresses, and 153 (82%) participated. Participants (median age = 61; 53% college-educated) demographically resembled non-participants. Cognitive scores spanned a broad range, demonstrating no floor/ceiling effects (immediate recall: 3 to 10; delayed recall: 1 to 10; digits forward: 3 to 8; digits backwards: 0 to 6; semantic fluency: 6 to 38 animals).
DISCUSSION: Home cognitive assessments may be feasible for large established cohorts in Latin America. These studies are promising for aging research.
PMID:42325003 | DOI:10.1002/alz.71569
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