- Neurogenic cardiac syndromes are cardiac rhythm, functional, and haemodynamic abnormalities triggered or amplified by neurologic injury, autonomic dysfunction, or stress-related CNS activation.
- Common mechanisms include sympathetic overactivation, vagal withdrawal, reduced heart rate variability and baroreflex sensitivity, neuroinflammation, endothelial dysfunction, and myocardial stunning.
- Practical classification integrates acute brain injury, seizures, chronic autonomic failure, stress cardiomyopathy, and heart failure phenotypes to guide recognition, monitoring, and multidisciplinary management.
Heart Fail Clin. 2026 Oct;22(4):409-417. doi: 10.1016/j.hfc.2026.07.006. Epub 2026 Aug 4.
ABSTRACT
Neurogenic cardiac syndromes (NCS) encompass cardiac rhythm, functional, and hemodynamic abnormalities triggered or amplified by neurologic injury, autonomic dysfunction, or stress-related central nervous system activation. This article summarizes the brain-heart axis, shared mechanisms including sympathetic overactivation, vagal withdrawal, impaired heart rate variability and baroreflex sensitivity, neuroinflammation, endothelial dysfunction, and myocardial stunning, and proposes a practical classification framework. Acute brain injury-related, seizure-related, chronic autonomic failure-related, stress-related, and heart failure-associated NCS phenotypes are integrated to support earlier recognition, monitoring, and multidisciplinary management.
PMID:42716651 | DOI:10.1016/j.hfc.2026.07.006
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