- Past-month active suicidal ideation was associated with more severe depressive and positive symptoms; only depressive symptom severity uniquely predicted ideation.
- Lifetime suicide attempt history related to older age and poorer working memory and processing speed; only older age uniquely predicted attempt history.
- Individuals with aborted attempts showed better premorbid intellectual functioning and working memory; working memory remained significant in multivariable analysis.
J Psychiatr Res. 2026 Oct 13;204:152-158. doi: 10.1016/j.jpsychires.2026.10.017. Online ahead of print.
ABSTRACT
BACKGROUND: Individuals with psychosis have elevated suicide risk and neuropsychological dysfunction. Prior research on neurocognition and suicidality in psychosis is mixed, with better cognition linked to both greater and lower history of suicide ideation (SI) and suicide attempts (SA). The current study examined associations between neuropsychological performance, demographics, psychiatric symptoms, past month SI, and lifetime SA history in individuals with psychosis.
METHOD: 235 adults with schizophrenia, schizoaffective disorder, or bipolar disorder with psychotic features completed clinical interviews, neuropsychological assessment, and symptom measures (positive and negative symptoms; depressive symptoms). Participants were grouped by past month active SI (SI+; n = 110) versus passive/no SI (SI-; n = 125) and lifetime actual SA history (SA+; n = 152) versus no SA (SA-; n = 83). Among SA + participants, we examined lifetime aborted attempts, interrupted attempts, preparatory behaviors, and attempt lethality. False Discovery Rate correction was used for multiple comparisons.
STUDY RESULTS: SI + individuals reported more severe depressive and positive symptoms; only depressive symptoms uniquely predicted SI. SA + individuals were significantly older and had worse working memory and processing speed than SA-individuals, but only age uniquely predicted SA history. Those with aborted attempt history demonstrated better premorbid intellectual functioning and working memory; only working memory remained significant in the multivariable model. After FDR correction, there were no significant predictors of interrupted attempts, preparatory behavior, or attempt lethality.
CONCLUSIONS: Current SI may be more closely associated with symptoms, whereas better working memory may be associated with aborting a suicide attempt.
PMID:42892098 | DOI:10.1016/j.jpsychires.2026.10.017
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
