Evidence
Neurosci Bull. 2024 Apr 24. doi: 10.1007/s12264-024-01206-1. Online ahead of print.
ABSTRACT
The existence of neural stem cells (NSCs) in the adult mammalian nervous system, although small in number and restricted to the sub-ventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, and the olfactory epithelium, is a gift of evolution for the adaptive brain function which requires persistent plastic changes of these regions. It is known that most adult NSCs are latent, showing long cell cycles. In the past decade, the concept of quiescent NSCs (qNSCs) has been widely accepted by researchers in the field, and great progress has been made in the biology of qNSCs. Although the spontaneous neuronal regeneration derived from adult NSCs is not significant, understanding how the behaviors of qNSCs are regulated sheds light on stimulating endogenous NSC-based neuronal regeneration. In this review, we mainly focus on the recent progress of the developmental origin and regulatory mechanisms that maintain qNSCs under normal conditions, and that mobilize qNSCs under pathological conditions, hoping to give some insights for future study.
PMID:38656419 | DOI:10.1007/s12264-024-01206-1
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
🌐 90 Days
VR Related Evidence Matrix
- Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
- Identity and nature of neural stem cells in the adult human subventricular zone
- Developmental Genetic and Molecular Analysis of Drosophila Central Complex Lineages
- Lineage Analysis and Birthdating of Drosophila Central Complex Lineages
- Single-nucleus RNA-seq characterizes the cell types along the neuronal lineage in the adult human subependymal zone and reveals reduced oligodendrocyte progenitor abundance with age
- On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies
- Dissecting the spatiotemporal diversity of adult neural stem cells
- Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
- The neuronal transcription factor MEIS2 is a calpain2 protease target
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb
- The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
- Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells
- Stem cell modeling of nervous system tumors
- Olfactory bulb anomalies in KBG syndrome mouse model and patients
- Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep: A Neuroscience Exploration
- Context Processing in Contextual and Cued Fear Extinction
- Mesenchymal stem cells as therapeutic vehicles for glioma
- Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
- Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review
- A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
- Stem Cell Secretions as a Potential Therapeutic Agent for Autism Spectrum Disorder: A Narrative Review
- MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field
- Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment
- Deficits in olfactory system neurogenesis in neurodevelopmental disorders
- Protocol for generating postganglionic sympathetic neurons using human pluripotent stem cells for electrophysiological and functional assessments
- Spermatogenesis: a paradigm of stem cell regulation
- Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
- Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice
- Altered hippocampal doublecortin expression in Parkinson's disease
- Cell-mediated nanoparticle delivery systems: towards precision nanomedicine
- Generation of human cerebral organoids with a structured outer subventricular zone
- Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice
- Joubert syndrome-derived induced pluripotent stem cells show altered neuronal differentiation in vitro
- Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder
- Morphological profiling in human neural progenitor cells classifies hits in a pilot drug screen for Alzheimer's disease
- The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond
- Intrinsic and synaptic contributions to repetitive spiking in dentate granule cells
- Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation
- Transcriptomic profiling of Dip2a in the neural differentiation of mouse embryonic stem cells
- Continuation of Pediatric Care after Transfer to Adult Care Among Autistic Youth Overlap of Pediatric and Adult Care
- Oxford early career researchers shine in Parliamentary competition
- Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
- An update on stem cell therapy for stroke patients: Where are we now?
- Neural circuits regulating visceral pain
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms
- Functional myelin in cognition and neurodevelopmental disorders
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Auditory training remodels hippocampus-related memory in adult rats
- Partial Reprogramming as a Method for Regenerating Neural Tissues in Aged Organisms
- Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex
- Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities
- Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities
- Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury
- Schwann Cell Development and Myelination
- Lateral geniculate body is spared of tau pathology in Pick disease
- Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture
- Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders
- Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
- Validation of Enhancer Regions in Primary Human Neural Progenitor Cells using Capture STARR-seq
- The Application of Extended Reality in Treating Children with Autism Spectrum Disorder
- Expression patterns of Piezo1 in the developing mouse forebrain
- Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells
Evidence Blueprint
Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
Save Evidence Blueprint
Save as PDF
Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
🌐 365 Days
VR Related Evidence Matrix
- Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
- Identity and nature of neural stem cells in the adult human subventricular zone
- Developmental Genetic and Molecular Analysis of Drosophila Central Complex Lineages
- Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal
- Lineage Analysis and Birthdating of Drosophila Central Complex Lineages
- Single-nucleus RNA-seq characterizes the cell types along the neuronal lineage in the adult human subependymal zone and reveals reduced oligodendrocyte progenitor abundance with age
- On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies
- Dissecting the spatiotemporal diversity of adult neural stem cells
- The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
- Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity
- GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke
- Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli
- Neurotrophins and neural stem cells in posttraumatic brain injury repair
- Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry
- Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
- Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity
- The neuronal transcription factor MEIS2 is a calpain2 protease target
- M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH
- Neural Cells for Neurodegenerative Diseases in Clinical Trials
- Concurrent impact of de novo mutations on cranial and cortical development in nonsyndromic craniosynostosis
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb
- The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
- Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells
- Mesenchymal Stem Cell-Induced Neuroprotection in Pediatric Neurological Diseases: Recent Update of Underlying Mechanisms and Clinical Utility
- Stem cell modeling of nervous system tumors
- The single-cell and spatial transcriptional landscape of human gastrulation and early brain development
- Olfactory bulb anomalies in KBG syndrome mouse model and patients
- The expansion of newborn neurons in hippocampus improves social recognition deficit in a mouse model of autism
- Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep: A Neuroscience Exploration
- Defects in early synaptic formation and neuronal function in Prader-Willi syndrome
- Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone
- Context Processing in Contextual and Cued Fear Extinction
- Mesenchymal stem cells as therapeutic vehicles for glioma
- Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis
- Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
- Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review
- The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment
- A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder
- A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
- Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
- Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
- Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury
- Stem Cell Secretions as a Potential Therapeutic Agent for Autism Spectrum Disorder: A Narrative Review
- Genomic Mosaicism of the Brain: Origin, Impact, and Utility
- MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field
- ISSCR standards for the use of human stem cells in basic research
- Advance and Application of Single-cell Transcriptomics in Auditory Research
- Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside
- Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues
- Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment
- Oxford researchers develop 3D printing method that shows promise for repairing brain injuries
- Autophagy collaborates with apoptosis pathways to control oligodendrocyte number
- Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)
- Primary Culture of the Human Olfactory Neuroepithelium and Utilization for Henipavirus Infection In Vitro
- Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell
- The Influence of Exosomes Derived from Mesenchymal Stem Cells on the Development of Fibrosis In Vitro
- Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells
- GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo
- Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells
- Deficits in olfactory system neurogenesis in neurodevelopmental disorders
- A Chiral Nanocomplex for Multitarget Therapy to Alleviate Neuropathology and Rescue Alzheimer's Cognitive Deficits
- ASCL1 induces neurogenesis in human Müller glia
- IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes