Evidence
Cold Spring Harb Perspect Biol. 2024 Mar 19:a041360. doi: 10.1101/cshperspect.a041360. Online ahead of print.
ABSTRACT
Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the neuromuscular junction, enteric glia, perikaryon-associated satellite cells in ganglia, and boundary cap cells at the border between the central nervous system (CNS) and the PNS. Here, we focus on axon-associated SCs. These SCs progress through a series of formative stages, which culminate in the generation of myelinating SCs that wrap large-caliber axons and of nonmyelinating (Remak) SCs that enclose multiple, small-caliber axons. In this work, we describe SC development, extrinsic signals from the axon and extracellular matrix (ECM) and the intracellular signaling pathways they activate that regulate SC development, and the morphogenesis and organization of myelinating SCs and the myelin sheath. We review the impact of SCs on the biology and integrity of axons and their emerging role in regulating peripheral nerve architecture. Finally, we explain how transcription and epigenetic factors control and fine-tune SC development and myelination.
PMID:38503507 | DOI:10.1101/cshperspect.a041360
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Schwann Cell Development and Myelination
🌐 90 Days
VR Related Evidence Matrix
- Regulators of Oligodendrocyte Differentiation
- Enhancing nurse retention: Insights from "SHOULD I STAY OR SHOULD I GO"
- Oligodendrocytes: Myelination, Plasticity, and Axonal Support
- Glial Cell Development and Function in the Zebrafish Central Nervous System
- The Regulatory Mechanism of Smilax China L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics
- Intentions to use mental health and suicide prevention resources among individuals with symptoms of the suicide crisis syndrome and/or suicidal ideation
- Modeling the associations between emotion regulation, suicide crisis syndrome and suicidal behavior: Results in community and clinical samples
- Generation of Mammalian Astrocyte Functional Heterogeneity
- A Systematic Review of the Application of Computational Technology in Microtia
- Relationship Between Severity and Length of Exposure to COVID-19 Parameters and Resulting Government Responses and the Suicide Crisis Syndrome (SCS)
- Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases
- Developmental Genetic and Molecular Analysis of Drosophila Central Complex Lineages
- Lineage Analysis and Birthdating of Drosophila Central Complex Lineages
- Machine learning approach for the development of a crucial tool in suicide prevention: The Suicide Crisis Inventory-2 (SCI-2) Short Form
- Actomyosin-II protects axons from degeneration induced by mild mechanical stress
- A Framework Based on Blockchain, Artificial Intelligence, and Big Data Analytics to Leverage Supply Chain Resilience considering the COVID-19
- Development of Prefrontal Circuits and Cognitive Abilities
- Investigation of Skull Cortical Thickness Changes in Healthy Population and Patients With Schizophrenia on Computed Tomography Images
- Functional myelin in cognition and neurodevelopmental disorders
- Suicide Crisis Syndrome: A systematic review
- GFAP-isoforms in the nervous system: Understanding the need for diversity
- Management of Maxillofacial Trauma in Pregnant Women
- Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System
- Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina
- Genes in Axonal Regeneration
- Pathogenesis and immunopathology of paraneoplastic disorders
- Context-specific stress causes compartmentalized SARM1 activation and local degeneration in cortical neurons
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex
- Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders
- Detection of delirium in older patients-A point prevalence study in surgical and non-surgical hospital wards
- Protocol for generating postganglionic sympathetic neurons using human pluripotent stem cells for electrophysiological and functional assessments
- Public health nurses' experiences with mental health promotion for adolescent immigrants in schools: A qualitative study
- Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells
- B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4
- Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
- INSPIRED Symposium Part 5: Expanding the Use of CAR T cells in Children and Young Adults
- A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
- Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model
- From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior
- From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior
- Interaction between central nervous system and immune system after ischemic stroke and its therapeutic significance of traditional Chinese medicine
- Laura Feltri: Of Schwann cells, matrix, and family
- BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
- Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy
- Generation of human cerebral organoids with a structured outer subventricular zone
- Dissecting the spatiotemporal diversity of adult neural stem cells
- Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
- Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
- Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device
- Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
- CAR T-cell therapy induces a high rate of prolonged remission in relapsed primary CNS lymphoma: Real-life results of the LOC network
- The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond
- Imaging Neuropeptide Release from Drosophila Clock and Motor Neurons
- BCKDK Modification Enhances the Anticancer Efficacy of CAR-T Cells by Reprogramming Branched Chain Amino Acid Metabolism
- Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment
- Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration
- Peripheral neuronal activation shapes the microbiome and alters gut physiology
- Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332
- On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies
- The major histocompatibility complex participates in Parkinson's disease
- The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- Computational Investigations of the Detailed Mechanism of Reverse Intersystem Crossing in Inverted Singlet-Triplet Gap Molecules
Evidence Blueprint
Schwann Cell Development and Myelination
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Schwann Cell Development and Myelination
🌐 365 Days
VR Related Evidence Matrix
- Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies
- Regulators of Oligodendrocyte Differentiation
- Enhancing nurse retention: Insights from "SHOULD I STAY OR SHOULD I GO"
- Oligodendrocytes: Myelination, Plasticity, and Axonal Support
- Perceived clinical utility of the suicide crisis syndrome: A multisite pilot study
- Function Follows Form: Oriented Substrate Nanotopography Overrides Neurite-Repulsive Schwann Cell-Astrocyte Barrier Formation in an In Vitro Model of Glial Scarring
- Glial Cell Development and Function in the Zebrafish Central Nervous System
- Novel Pulsed-Ultrahigh-Frequency Spinal Cord Stimulation Inhibits Mechanical Hypersensitivity and Brain Neuronal Activity in Rats after Nerve Injury
- The Regulatory Mechanism of Smilax China L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics
- Reliability and validity of the Suicide Cognitions Scale-Revised (SCS-R) in emerging adulthood in Turkey
- The multiple makings of a supervised consumption service in a hospital setting
- Intentions to use mental health and suicide prevention resources among individuals with symptoms of the suicide crisis syndrome and/or suicidal ideation
- Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
- Mitf is a Schwann cell sensor of axonal integrity that drives nerve repair
- Modeling the associations between emotion regulation, suicide crisis syndrome and suicidal behavior: Results in community and clinical samples
- Generation of Mammalian Astrocyte Functional Heterogeneity
- A Systematic Review of the Application of Computational Technology in Microtia
- Spinal calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with facet joint pathologies: CAPNON diagnostic and pathogenic insights
- Presentation and Treatment of a Patient With Jacobs Syndrome and Metopic Craniosynostosis
- Characteristics of Users and Nonusers of Symptom Checkers in Germany: Cross-Sectional Survey Study
- Inflammation in pathogenesis of chronic pain: Foe and friend
- Patient profiling and outcome assessment in spinal cord stimulation for chronic back and/or leg pain (the PROSTIM study): a study protocol
- Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
- An axon-T cell feedback loop enhances inflammation and axon degeneration
- Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
- Relationship Between Severity and Length of Exposure to COVID-19 Parameters and Resulting Government Responses and the Suicide Crisis Syndrome (SCS)
- The systemic immune response in Parkinson's disease: focus on the peripheral immune component
- Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases
- Primary Culture of the Human Olfactory Neuroepithelium and Utilization for Henipavirus Infection In Vitro
- Developmental Genetic and Molecular Analysis of Drosophila Central Complex Lineages
- Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program
- PMP2 regulates myelin thickening and ATP production during remyelination
- Lineage Analysis and Birthdating of Drosophila Central Complex Lineages
- Machine learning approach for the development of a crucial tool in suicide prevention: The Suicide Crisis Inventory-2 (SCI-2) Short Form
- Actomyosin-II protects axons from degeneration induced by mild mechanical stress
- Neural Cells for Neurodegenerative Diseases in Clinical Trials
- A Framework Based on Blockchain, Artificial Intelligence, and Big Data Analytics to Leverage Supply Chain Resilience considering the COVID-19
- Development of Prefrontal Circuits and Cognitive Abilities
- AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells
- Thematic Analysis of Parental Experiences of Patients' Orthognathic Surgery
- Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children
- Investigation of Skull Cortical Thickness Changes in Healthy Population and Patients With Schizophrenia on Computed Tomography Images
- The synthetic cannabinoid 5F-MDMB-PICA enhances the metabolic activity and angiogenesis in human brain microvascular endothelial cells by upregulation of VEGF, ANG-1, and ANG-2
- Advances in Large Gap Peripheral Nerve Injury Repair and Regeneration with Bridging Nerve Guidance Conduits
- Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?
- Functional myelin in cognition and neurodevelopmental disorders
- Suicide Crisis Syndrome: A systematic review
- The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons
- GFAP-isoforms in the nervous system: Understanding the need for diversity
- Management of Maxillofacial Trauma in Pregnant Women
- Optogenetic Vision Restoration
- B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis
- Supercomplex formation of mitochondrial respiratory chain complexes in leukocytes from patients with neurodegenerative diseases
- Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System
- Repeat intramuscular transplantation of human dental pulp stromal cells is more effective in sustaining Schwann cell survival and myelination for functional recovery after onset of diabetic neuropathy
- Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina
- Genes in Axonal Regeneration
- Pathogenesis and immunopathology of paraneoplastic disorders
- AMD3100-mediated CXCR4 inhibition impairs development of primary lymphoma of the central nervous system
- The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border
- Context-specific stress causes compartmentalized SARM1 activation and local degeneration in cortical neurons
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex
- Validation of the 12 items self-compassion scale in Chile
- How myeloid cells shape experimental autoimmune encephalomyelitis: at the crossroads of outside-in immunity