Evidence
J Biotechnol. 2024 Mar 17:S0168-1656(24)00076-2. doi: 10.1016/j.jbiotec.2024.03.006. Online ahead of print.
ABSTRACT
Ethyl carbamate (EC), a multisite carcinogenic compound, is naturally produced from urea and ethanol in alcoholic beverages. In order to reduce the content of EC in wine, the accumulation of arginine in Saccharomyces cerevisiae was regulated by genetic modifying genes involved in arginine transport and synthesis pathways to reduce the production of urea. Knockout of genes encoding arginine permease (Can1p) and amino acid permease (Gap1p) on the cell membrane as well as argininosuccinate synthase (Arg1) respectively resulted in a maximum reduction of 66.88% (9.40µg/L) in EC, while overexpressing the gene encoding amino acid transporter (Vba2) reduced EC by 52.94% (24.13µg/L). Simultaneously overexpressing Vba2 and deleting Arg1 showed the lowest EC production with a decrease of 68% (7.72µg/L). The yield of total higher alcohols of the mutants all decreased compared with that of the original strain. Comprehensive consideration of flavor compound contents and sensory evaluation results indicated that mutant YG21 obtained by deleting two allele coding Gap1p performed best in must fermentation of Cabernet Sauvignon with the EC content low to 9.40μg/L and the contents of total higher alcohols and esters of 245.61mg/L and 41.71mg/L respectively. This study has provided an effective strategy for reducing the EC in wine.
PMID:38503366 | DOI:10.1016/j.jbiotec.2024.03.006
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
Reduced production of Ethyl Carbamate in wine by regulating the accumulation of arginine in Saccharomyces cerevisiae
🌐 90 Days
VR Related Evidence Matrix
- Antifungal activities of vineyard-habitat wild yeast for grape gray-mold disease and its effects on spontaneous winemaking
- Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport
- Development of an Integrated Bioprocess System for Bioethanol and Arabitol Production from Sugar Beet Cossettes
- Evaluation of enzyme-constrained genome-scale model through metabolic engineering of anaerobic co-production of 2,3-butanediol and glycerol by Saccharomyces cerevisiae
- Extracts of tropical green seaweed Caulerpa lentillifera reduce hepatic lipid accumulation by modulating lipid metabolism molecules in HepG2 cells
- Determination of 10 mycotoxins in wine, baijiu, and huangjiu of the Chinese market by liquid chromatography tandem mass spectrometry and exposure estimation
- Analysis of the therapeutic potential of miR-124 and miR-16 in non-alcoholic fatty liver disease
- Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy
- Expanding TheCellVision.org: A Central Repository for Visualizing and Mining High-Content Cell Imaging Projects
- A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota
- Comparative phenotype and transcriptome analysis revealed the role of ferric uptake regulator (Fur) in the virulence of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata)
- Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota
- PMP2 regulates myelin thickening and ATP production during remyelination
- Exploration of carbonyl compounds in red-fleshed kiwifruit wine and perceptual interactions among non-volatile organic acids
- Co-evolution of gene transfer agents and their alphaproteobacterial hosts
- Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?
- Valorisation of cotton post-industrial textile waste into lactic acid: chemo-mechanical pretreatment, separate hydrolysis and fermentation using engineered yeast
- Chronic exposure to 3,6-dichlorocarbazole exacerbates non-alcoholic fatty liver disease in zebrafish by disrupting lipid metabolism and inducing special lipid biomarker accumulation
- The Protease Activated Receptor 2 - CCAAT/Enhancer-Binding Protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of Non-Alcoholic Steatohepatitis
- m6A RNA methylation regulates mitochondrial function
- Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons
- Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis
- Impact on wine sales of removing the largest serving size by the glass: An A-B-A reversal trial in 21 pubs, bars, and restaurants in England
- Gypenoside XIII regulates lipid metabolism in HepG2 hepatocytes and ameliorates nonalcoholic steatohepatitis in mice
- Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma
- Identification of a molecular network regulated by multiple ASD high risk genes
- Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis
- Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans
- Changes in splenic tissue and immune response profile of Schistosoma mansoni infected mice submitted to chronic ethanol intake
- iPSC-derived models for anorexia nervosa research
- Drosophila melanogaster models of MPS IIIC (Hgsnat-deficiency) highlight the role of glia in disease presentation
- ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
- A State-of-the-Science Review of Alcoholic Beverages and Polycyclic Aromatic Hydrocarbons
- miR-92a-3p regulates ethanol-induced apoptosis in H9c2 cardiomyocytes
- Is coffee, tea, and red wine consumption beneficial for individuals with hypertension?
- Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism
- Alcohol Promotes Lipogenesis in Sebocytes-Implications for Acne
- Polysaccharide from Panax japonicus C.A. Mey prevents non-alcoholic fatty liver disease development based on regulating liver metabolism and gut microbiota in mice
- From inspection to analysis: A combined approach to identifying counterfeit whiskeys using HS-GC-FID and bottle integrity
- Nutrient deprivation induces mouse embryonic diapause mediated by Gator1 and Tsc2
- Xiaozhi Formula Attenuates Non-Alcoholic Fatty Liver Disease by Regulating Lipid Metabolism via Activation of AMPK and PPAR pathways
- Xiaozhi Formula Attenuates Non-Alcoholic Fatty Liver Disease by Regulating Lipid Metabolism via Activation of AMPK and PPAR pathways
- Fibroblast growth factor 19 alters bile acids to induce dysbiosis in mice with alcohol-induced liver disease
- Fibroblast growth factor 19 alters bile acids to induce dysbiosis in mice with alcohol-induced liver disease
- Plant miR8126-3p and miR8126-5p Decrease Lipid Accumulation through Modulation of Metabolic Genes in a Human Hepatocyte Model That Mimics Steatosis
- LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA
- Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation
- High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma
- α-Mangostin suppresses ethanol-induced gastric ulceration by regulating the Nrf2/HO-1 and NF-κB/NLRP3/caspase-1 signaling pathways and gut microbiota
- Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
- Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice
- Identification of immunogenic cell death-related genes involved in Alzheimer's disease
- Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy
- Extract of Silphium perfoliatum L. improve lipid accumulation in NAFLD mice by regulating AMPK/FXR signaling pathway
- Physicochemical and microbiological changes during two-stage fermentation production of umqombothi
- Physicochemical and microbiological changes during two-stage fermentation production of umqombothi
- Copy number variant risk loci for schizophrenia converge on the BDNF pathway
- Starstruck Lens: Iatrogenic Rosette Cataract and Its Spontaneous Resolution
- Nacc1 mutation in mice models rare neurodevelopmental disorder with underlying synaptic dysfunction
- Isoflurane preconditioning induced genomic changes in mouse cortex
- A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells
- Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder
- Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1
- Exercise ameliorates lipid droplet metabolism disorder by the PLIN2-LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease
Evidence Blueprint
Reduced production of Ethyl Carbamate in wine by regulating the accumulation of arginine in Saccharomyces cerevisiae
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
Save Evidence Blueprint
Save as PDF
Reduced production of Ethyl Carbamate in wine by regulating the accumulation of arginine in Saccharomyces cerevisiae
🌐 365 Days
VR Related Evidence Matrix
- Ethyl Carbamate in Fermented Food Products: Sources of Appearance, Hazards and Methods for Reducing Its Content
- Isolation of Yeast Strains with Higher Proline Uptake and Their Applications to Beer Fermentation
- Succinic acid production by wine yeasts and the influence of GABA and glutamic acid
- Understanding the role of GRE3 in the erythritol biosynthesis pathway in Saccharomyces uvarum and its implication in osmoregulation and redox homeostasis
- QTL mapping reveals novel genes and mechanisms underlying variations in H2S production during alcoholic fermentation in Saccharomyces cerevisiae
- Dynamic genome-scale modeling of Saccharomyces cerevisiae unravels mechanisms for ester formation during alcoholic fermentation
- Discovering the effect of co-fermentation involving Saccharomyces cerevisiae and Schizosaccharomyces pombe on the sensory quality improvement of mandarin wine based on metabolites and transcriptomic profiles
- Alcoholic and non-alcoholic rosé wines made with Saccharomyces cerevisiae var. boulardii probiotic yeast
- The Role of the PAA1 Gene on Melatonin Biosynthesis in Saccharomyces cerevisiae: A Search of New Arylalkylamine N-Acetyltransferases
- Pilot-scale bioethanol production from the starch of avocado seeds using a combination of dilute acid-based hydrolysis and alcoholic fermentation by Saccharomyces cerevisiae
- Mixed biofilm formation by Oenococcus oeni and Saccharomyces cerevisiae: A new strategy for the wine fermentation process
- Single versus dual inoculation with indigenous Saccharomyces cerevisiae strains in winemaking
- Study of Different Types of Fermentation in Wine-Making Process and Considering Aromatic Substances and Organic Acid
- Metagenomic analysis of the relationship between the microorganisms and the volatiles' development in the wines during spontaneous fermentation from the eastern foothills of the Ningxia Helan Mountains in China
- Comparison of phenolic composition and sensory quality among pear beverages made using Saccharomyces cerevisiae and Torulaspora delbrueckii
- CARM1 Arginine Methyltransferase as a Therapeutic Target for Cancer
- Genomic analysis of Kazachstania aerobia and Kazachstania servazzii reveals duplication of genes related to acetate ester production
- The use of Torulaspora delbrueckii to improve malolactic fermentation
- Magnetic amyloid-based biocatalyst for the hydrolysis of urea
- Sake yeast symbiosis with lactic acid bacteria and alcoholic fermentation
- Insights into microbial communities and metabolic profiles in the traditional production of the two representative Hongqu rice wines fermented with Gutian Qu and Wuyi Qu based on single-molecule real-time sequencing
- Developing a novel selection method for alcoholic fermentation starters by exploring wine yeast microbiota from Greece
- Antifungal activities of vineyard-habitat wild yeast for grape gray-mold disease and its effects on spontaneous winemaking
- Arginine methylation of RNA-binding proteins is impaired in Huntington's disease
- Adaptation of yeast Saccharomyces cerevisiae to grape-skin environment
- Health risk assessment of ethyl carbamate in fruit spirits
- Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport
- Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation
- Effects of arginine on coenzyme-Q10 micelle uptake for mitochondria-targeted nanotherapy in phenylketonuria
- Mechanisms of production and control of acetate esters in yeasts
- Biosynthesis of silver nanoparticles using nitrate reductase from Aspergillus terreus N4 and their potential use as a non-alcoholic disinfectant
- Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review
- Alcoholic fermentation drives the selection of Oenococcus oeni strains in wine but not in cider
- Spontaneous Attenuation of Alcoholic Fermentation via the Dysfunction of Cyc8p in Saccharomyces cerevisiae
- From bioprotective effects to diversification of wine aroma: Expanding the knowledge on Metschnikowia pulcherrima oenological potential
- Development of an Integrated Bioprocess System for Bioethanol and Arabitol Production from Sugar Beet Cossettes
- Evaluation of Foodborne Pathogen Die-off in Back-Sweetened Wine and Apple Cider Models
- Evaluation of enzyme-constrained genome-scale model through metabolic engineering of anaerobic co-production of 2,3-butanediol and glycerol by Saccharomyces cerevisiae
- Extracts of tropical green seaweed Caulerpa lentillifera reduce hepatic lipid accumulation by modulating lipid metabolism molecules in HepG2 cells
- Biodiversity and brewing attitude of non-Saccharomyces strains isolated from Uruguayan vineyards and other ecosystems
- Flor yeast immobilization in microbial biocapsules for Sherry wine production: microvinification approach
- Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis
- Plasma metabolomics and network pharmacology identified glutamate, glutamine, and arginine as biomarkers of depression under Shuganjieyu capsule treatment
- Effect of LuxS/AI-2-mediated quorum sensing system on bacteriocin production of Lactobacillus plantarum NMD-17
- Determination of 10 mycotoxins in wine, baijiu, and huangjiu of the Chinese market by liquid chromatography tandem mass spectrometry and exposure estimation
- Corrigendum to "Redox cofactor metabolism in Saccharomyces cerevisiae and its impact on the production of alcoholic fermentation end-products" [Food Res. Int. 163 (2023) 112276]
- Analysis of the therapeutic potential of miR-124 and miR-16 in non-alcoholic fatty liver disease
- Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy
- Expanding TheCellVision.org: A Central Repository for Visualizing and Mining High-Content Cell Imaging Projects
- A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota
- Study on the relationship between flavor components and quality of ice wine during freezing and brewing of 'beibinghong' grapes
- Comparative phenotype and transcriptome analysis revealed the role of ferric uptake regulator (Fur) in the virulence of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata)
- Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota
- PMP2 regulates myelin thickening and ATP production during remyelination
- BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty acid oxidation in BALB/c mice
- Effects of film-forming Pichia and Candida yeasts on cider and wine as post-fermentation contaminants
- Dosing oxygen from the early stages of white winemaking: Effect on oxidation-reduction potential, browning stability, volatile composition, and sensory properties
- Yeast cell vacuum infusion into fungal pellets as a novel cell encapsulation methodology
- Exploration of carbonyl compounds in red-fleshed kiwifruit wine and perceptual interactions among non-volatile organic acids
- Co-evolution of gene transfer agents and their alphaproteobacterial hosts
- Alcohol, health loss and mortality: can wine really save the good name of moderate alcohol consumption?
- Disrupted phase behavior of FUS underlies poly-PR-induced DNA damage in amyotrophic lateral sclerosis
- Role of ammonia in NAFLD: An unusual suspect
- BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease