Response to correspondence: “Reappraising the neurovascular link between arterial stiffness and neuropathy: proposal for a neurovascular uncoupling index”
AI Summary
Defends neurovascular uncoupling index as physiologically grounded metric linking arterial stiffness to peripheral neuropathy, clarifying conceptual basis and expected pathways.
Addresses methodological critiques, detailing measurement techniques, confounder adjustment, and reproducibility considerations for index derivation.
Urges prospective validation across cohorts and outlines translational potential for risk stratification and therapeutic targeting of neurovascular dysfunction.
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